Micro Spectrophotometric Determination and Cloud Point Extraction of Sulphadimidine Sodium in Pure form and Pharmaceutical Drug
Two simple, rapid, and useful spectrophotometric methods were suggest or the determination of sulphadimidine sodium (SDMS) with and without using cloud point extraction technique in pure form and pharmaceutical preparation. The first method was based on diazotization of the Sulphdimidine Sodium dr...
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University of Baghdad, College of Science for Women
2019-06-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3465 |
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| author | Dhahir et al. |
| author_facet | Dhahir et al. |
| author_sort | Dhahir et al. |
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| description | Two simple, rapid, and useful spectrophotometric methods were suggest or the determination of sulphadimidine sodium (SDMS) with and without using cloud point extraction technique in pure form and pharmaceutical preparation. The first method was based on diazotization of the Sulphdimidine Sodium drug by sodium nitrite at 5 ºC, followed by coupling with α –Naphthol in basic medium to form an orange colored product . The product was stabilized and its absorption was measured at 473 nm. Beer’s law was obeyed in the concentration range of (1-12) μg∙ml-1. Sandell’s sensitivity was 0.03012 μg∙cm-1, the detection limit was 0.0277 μg∙ml-1, and the limit of Quantitation was 0.03605μg∙ml-1.The second method was the cloud point extraction (CPE) using Trtion X-114 as surfactant. Beer’s law was obeyed in the concentration range of (1-12) μg∙ml-1. Sandell’s sensitivity was 0.02958 μg∙cm-1, the detection limit was 0.01745 μg∙ml-1, and the limit of quantitation was 0.028303 μg∙ml-1. All variables including the reagent concentration, reaction time, color stability period, and mole ratio were studied in order to optimize the reaction conditions. The mole ratio for the composition of product is (1:1). Both methods were effectively useful to the determination of sulphdimidine sodium in pharmaceutical dose form. The attained results were in a good agreement with the official and other methods in the literature .No interference were observed from the commonly encountered additives and excipients. |
| format | Article |
| id | doaj-art-78e6b09c41ff4adbad916e928136c9a7 |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2019-06-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-78e6b09c41ff4adbad916e928136c9a72025-08-20T03:57:08ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862019-06-0116210.21123/bsj.16.2.0332Micro Spectrophotometric Determination and Cloud Point Extraction of Sulphadimidine Sodium in Pure form and Pharmaceutical DrugDhahir et al.Two simple, rapid, and useful spectrophotometric methods were suggest or the determination of sulphadimidine sodium (SDMS) with and without using cloud point extraction technique in pure form and pharmaceutical preparation. The first method was based on diazotization of the Sulphdimidine Sodium drug by sodium nitrite at 5 ºC, followed by coupling with α –Naphthol in basic medium to form an orange colored product . The product was stabilized and its absorption was measured at 473 nm. Beer’s law was obeyed in the concentration range of (1-12) μg∙ml-1. Sandell’s sensitivity was 0.03012 μg∙cm-1, the detection limit was 0.0277 μg∙ml-1, and the limit of Quantitation was 0.03605μg∙ml-1.The second method was the cloud point extraction (CPE) using Trtion X-114 as surfactant. Beer’s law was obeyed in the concentration range of (1-12) μg∙ml-1. Sandell’s sensitivity was 0.02958 μg∙cm-1, the detection limit was 0.01745 μg∙ml-1, and the limit of quantitation was 0.028303 μg∙ml-1. All variables including the reagent concentration, reaction time, color stability period, and mole ratio were studied in order to optimize the reaction conditions. The mole ratio for the composition of product is (1:1). Both methods were effectively useful to the determination of sulphdimidine sodium in pharmaceutical dose form. The attained results were in a good agreement with the official and other methods in the literature .No interference were observed from the commonly encountered additives and excipients.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3465Cloud Point Extraction, α –Naphthol, Sulphdimidine Sodium, Triton X-114 |
| spellingShingle | Dhahir et al. Micro Spectrophotometric Determination and Cloud Point Extraction of Sulphadimidine Sodium in Pure form and Pharmaceutical Drug مجلة بغداد للعلوم Cloud Point Extraction, α –Naphthol, Sulphdimidine Sodium, Triton X-114 |
| title | Micro Spectrophotometric Determination and Cloud Point Extraction of Sulphadimidine Sodium in Pure form and Pharmaceutical Drug |
| title_full | Micro Spectrophotometric Determination and Cloud Point Extraction of Sulphadimidine Sodium in Pure form and Pharmaceutical Drug |
| title_fullStr | Micro Spectrophotometric Determination and Cloud Point Extraction of Sulphadimidine Sodium in Pure form and Pharmaceutical Drug |
| title_full_unstemmed | Micro Spectrophotometric Determination and Cloud Point Extraction of Sulphadimidine Sodium in Pure form and Pharmaceutical Drug |
| title_short | Micro Spectrophotometric Determination and Cloud Point Extraction of Sulphadimidine Sodium in Pure form and Pharmaceutical Drug |
| title_sort | micro spectrophotometric determination and cloud point extraction of sulphadimidine sodium in pure form and pharmaceutical drug |
| topic | Cloud Point Extraction, α –Naphthol, Sulphdimidine Sodium, Triton X-114 |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3465 |
| work_keys_str_mv | AT dhahiretal microspectrophotometricdeterminationandcloudpointextractionofsulphadimidinesodiuminpureformandpharmaceuticaldrug |