Radiation exposure reduction in peripheral interventions using digital variance angiography versus conventional angiography
Abstract Digital variance angiography (DVA) exhibits promising prospects with respect to radiation exposure in digital subtraction angiography (DSA). This study aimed to determine the reduction of radiation dose in endovascular peripheral interventions (EPI) using DVA. The DVA imaging tool v6.0 (Kin...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-06361-7 |
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| author | Till Schürmann Ulrich Beschorner Dirk Westermann Thomas Zeller Fabian Bamberg Christopher L. Schlett Thomas Stein Elias Noory |
| author_facet | Till Schürmann Ulrich Beschorner Dirk Westermann Thomas Zeller Fabian Bamberg Christopher L. Schlett Thomas Stein Elias Noory |
| author_sort | Till Schürmann |
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| description | Abstract Digital variance angiography (DVA) exhibits promising prospects with respect to radiation exposure in digital subtraction angiography (DSA). This study aimed to determine the reduction of radiation dose in endovascular peripheral interventions (EPI) using DVA. The DVA imaging tool v6.0 (Kinepict Medical Imaging Tool, version 6.0.4, Kinepict Health Ltd., Budapest, Hungary) was utilized for patients undergoing EPI using digital angiography. EPI normal dose (EPI-ND) protocols were adapted from 1.20 to 0.81 µGy/frame to EPI low dose (EPI-LD) protocols using DVA-LD acquisitions with 0.36 µGy/frame and occasionally 0.24 µGy/frame based on specific examination requirements. The dose area product (DAP) was evaluated and contrast-to-noise ratio (CNR) was measured for each DSA acquisition. Evaluation included 370 EPI-ND and 62 EPI-LD using DVA-LD of three lower extremity regions (mean age: 73 ± 11 years, 67% male). LD protocols decreased median DAP of ND protocols significantly by 62.0% in pelvic, 53.8% in femoral and popliteal, and 59.4% in cruro-pedal regions, respectively (p < .005). DVA-LD increased median CNR significantly compared to DSA-LD (p < .001), and was equal to DSA-ND (p > .15). Image quality was enhanced by CNRDVA−LD/CNRDSA−ND ratio of 1.9 in pelvic, 2.4 in femoral and popliteal and in cruro-pedal regions. DVA reveals significant radiation dose reduction in lower extremity EPIs and enhances image contrast while decreasing noise. |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-78e5d8dfd53640a7b0f8fc0f336db5ba2025-08-20T04:03:07ZengNature PortfolioScientific Reports2045-23222025-07-0115111110.1038/s41598-025-06361-7Radiation exposure reduction in peripheral interventions using digital variance angiography versus conventional angiographyTill Schürmann0Ulrich Beschorner1Dirk Westermann2Thomas Zeller3Fabian Bamberg4Christopher L. Schlett5Thomas Stein6Elias Noory7Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of FreiburgDepartment of Cardiology and Angiology, University Heart Center, University Medical Center Freiburg, Faculty of Medicine, University of FreiburgDepartment of Cardiology and Angiology, University Heart Center, University Medical Center Freiburg, Faculty of Medicine, University of FreiburgDepartment of Cardiology and Angiology, University Heart Center, University Medical Center Freiburg, Faculty of Medicine, University of FreiburgDepartment of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of FreiburgDepartment of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of FreiburgDepartment of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of FreiburgDepartment of Cardiology and Angiology, University Heart Center, University Medical Center Freiburg, Faculty of Medicine, University of FreiburgAbstract Digital variance angiography (DVA) exhibits promising prospects with respect to radiation exposure in digital subtraction angiography (DSA). This study aimed to determine the reduction of radiation dose in endovascular peripheral interventions (EPI) using DVA. The DVA imaging tool v6.0 (Kinepict Medical Imaging Tool, version 6.0.4, Kinepict Health Ltd., Budapest, Hungary) was utilized for patients undergoing EPI using digital angiography. EPI normal dose (EPI-ND) protocols were adapted from 1.20 to 0.81 µGy/frame to EPI low dose (EPI-LD) protocols using DVA-LD acquisitions with 0.36 µGy/frame and occasionally 0.24 µGy/frame based on specific examination requirements. The dose area product (DAP) was evaluated and contrast-to-noise ratio (CNR) was measured for each DSA acquisition. Evaluation included 370 EPI-ND and 62 EPI-LD using DVA-LD of three lower extremity regions (mean age: 73 ± 11 years, 67% male). LD protocols decreased median DAP of ND protocols significantly by 62.0% in pelvic, 53.8% in femoral and popliteal, and 59.4% in cruro-pedal regions, respectively (p < .005). DVA-LD increased median CNR significantly compared to DSA-LD (p < .001), and was equal to DSA-ND (p > .15). Image quality was enhanced by CNRDVA−LD/CNRDSA−ND ratio of 1.9 in pelvic, 2.4 in femoral and popliteal and in cruro-pedal regions. DVA reveals significant radiation dose reduction in lower extremity EPIs and enhances image contrast while decreasing noise.https://doi.org/10.1038/s41598-025-06361-7Digital variance angiographyDigital subtraction angiographyEndovascular peripheral interventionsX-rayRadiation dose |
| spellingShingle | Till Schürmann Ulrich Beschorner Dirk Westermann Thomas Zeller Fabian Bamberg Christopher L. Schlett Thomas Stein Elias Noory Radiation exposure reduction in peripheral interventions using digital variance angiography versus conventional angiography Scientific Reports Digital variance angiography Digital subtraction angiography Endovascular peripheral interventions X-ray Radiation dose |
| title | Radiation exposure reduction in peripheral interventions using digital variance angiography versus conventional angiography |
| title_full | Radiation exposure reduction in peripheral interventions using digital variance angiography versus conventional angiography |
| title_fullStr | Radiation exposure reduction in peripheral interventions using digital variance angiography versus conventional angiography |
| title_full_unstemmed | Radiation exposure reduction in peripheral interventions using digital variance angiography versus conventional angiography |
| title_short | Radiation exposure reduction in peripheral interventions using digital variance angiography versus conventional angiography |
| title_sort | radiation exposure reduction in peripheral interventions using digital variance angiography versus conventional angiography |
| topic | Digital variance angiography Digital subtraction angiography Endovascular peripheral interventions X-ray Radiation dose |
| url | https://doi.org/10.1038/s41598-025-06361-7 |
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