Plasma galectin-3 can be considered as a non-invasive marker to predict the prognosis of ACLF patients with new typing
Abstract Very recently, we creatively put forward a new classification for ACLF patients, which lays the foundation for the establishment of prognostic model that can accurately predict the prognosis of ACLF patients. Herein, we found: galectin-3 levels were higher in type A ACLF patients compared t...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-87557-9 |
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| author | Li Bai Wang Lu Qi Yang Xiaoxuan Liu Yu Chen Zhongping Duan |
| author_facet | Li Bai Wang Lu Qi Yang Xiaoxuan Liu Yu Chen Zhongping Duan |
| author_sort | Li Bai |
| collection | DOAJ |
| description | Abstract Very recently, we creatively put forward a new classification for ACLF patients, which lays the foundation for the establishment of prognostic model that can accurately predict the prognosis of ACLF patients. Herein, we found: galectin-3 levels were higher in type A ACLF patients compared to those of type B patients; galectin-3 expression was closely correlated with TBil, PTA/INR and MELD; galectin-3 is an independent predictive factor for rapid progression in ACLF, and exhibited superior predictive value for the prognosis of type A ACLF patients than MELD score; and the survival rate was remarkably higher in ACLF patients with lower galectin-3 expression. Collectively, galectin-3 can be considered as a non-invasive biomarker to predict the prognosis of ACLF patients with new typing. Our findings help advance the time window of prognosis prediction for type A and type B ACLF patients from 4 weeks to the baseline, thereby identifying ACLF patients who really need liver transplantation earlier and improving the survival of ACLF patients. |
| format | Article |
| id | doaj-art-78d842d6880540dbb6d13630c46047fa |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-78d842d6880540dbb6d13630c46047fa2025-02-02T12:19:54ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-87557-9Plasma galectin-3 can be considered as a non-invasive marker to predict the prognosis of ACLF patients with new typingLi Bai0Wang Lu1Qi Yang2Xiaoxuan Liu3Yu Chen4Zhongping Duan5Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical UniversityFourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical UniversityFourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical UniversityFourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical UniversityFourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical UniversityFourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical UniversityAbstract Very recently, we creatively put forward a new classification for ACLF patients, which lays the foundation for the establishment of prognostic model that can accurately predict the prognosis of ACLF patients. Herein, we found: galectin-3 levels were higher in type A ACLF patients compared to those of type B patients; galectin-3 expression was closely correlated with TBil, PTA/INR and MELD; galectin-3 is an independent predictive factor for rapid progression in ACLF, and exhibited superior predictive value for the prognosis of type A ACLF patients than MELD score; and the survival rate was remarkably higher in ACLF patients with lower galectin-3 expression. Collectively, galectin-3 can be considered as a non-invasive biomarker to predict the prognosis of ACLF patients with new typing. Our findings help advance the time window of prognosis prediction for type A and type B ACLF patients from 4 weeks to the baseline, thereby identifying ACLF patients who really need liver transplantation earlier and improving the survival of ACLF patients.https://doi.org/10.1038/s41598-025-87557-9Acute-on-chronic liver failureNew classificationGalectin-3Prognosis prediction |
| spellingShingle | Li Bai Wang Lu Qi Yang Xiaoxuan Liu Yu Chen Zhongping Duan Plasma galectin-3 can be considered as a non-invasive marker to predict the prognosis of ACLF patients with new typing Scientific Reports Acute-on-chronic liver failure New classification Galectin-3 Prognosis prediction |
| title | Plasma galectin-3 can be considered as a non-invasive marker to predict the prognosis of ACLF patients with new typing |
| title_full | Plasma galectin-3 can be considered as a non-invasive marker to predict the prognosis of ACLF patients with new typing |
| title_fullStr | Plasma galectin-3 can be considered as a non-invasive marker to predict the prognosis of ACLF patients with new typing |
| title_full_unstemmed | Plasma galectin-3 can be considered as a non-invasive marker to predict the prognosis of ACLF patients with new typing |
| title_short | Plasma galectin-3 can be considered as a non-invasive marker to predict the prognosis of ACLF patients with new typing |
| title_sort | plasma galectin 3 can be considered as a non invasive marker to predict the prognosis of aclf patients with new typing |
| topic | Acute-on-chronic liver failure New classification Galectin-3 Prognosis prediction |
| url | https://doi.org/10.1038/s41598-025-87557-9 |
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