SMAD4 promotes EMT in COPD airway remodeling induced by cigarette smoke through interaction with O-GlcNAc transferase

SMAD4 promotes EMT in COPD airway remodeling induced by cigarette smoke through interaction with O-GlcNAc transferase

Cigarette smoke (CS) is a prevalent chemical indoor air contaminant known to be the primary cause of EMT during airway remodeling in COPD. While some evidence indicates the involvement of SMAD4 in EMT across certain diseases, its specific role in CS-induced EMT in airway remodeling associated with C...

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Bibliographic Details
Main Authors: Ziteng Wang, Yu Ding, Pei Wang, Jinyan Yu, Shulun Huang, Lingjia Yang, Hongjing Gong, Zhen Yu, Rongguo Lu, Tao Bian, Yan Wu
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Cigarette smoke
SMAD4
O-GlcNAc transferase
Airway remodeling
Epithelial-mesenchymal transition (EMT)
COPD
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324010078
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