The Interleukin-6 Gene Promoter Polymorphism -174 and Atherosclerotic Events in Overweight Transplanted Patients
Chronic inflammation plays a pivotal role in atherosclerosis. We hypothesized that combining overweight and a greater genetic capacity to produce IL-6 predicted by IL-6 gene promoter polymorphism at position -174 (G→C) may allow to identify individuals exhibiting higher IL-6 and C-reactive protein (...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2011/803429 |
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| author | Jamal Bamoulid Cécile Courivaud Marina Deschamps Béatrice Gaugler Pierre Tiberghien Jean-Marc Chalopin Philippe Saas Didier Ducloux |
| author_facet | Jamal Bamoulid Cécile Courivaud Marina Deschamps Béatrice Gaugler Pierre Tiberghien Jean-Marc Chalopin Philippe Saas Didier Ducloux |
| author_sort | Jamal Bamoulid |
| collection | DOAJ |
| description | Chronic inflammation plays a pivotal role in atherosclerosis. We hypothesized that combining overweight and a greater genetic capacity to produce IL-6 predicted by IL-6 gene promoter polymorphism at position -174 (G→C) may allow to identify individuals exhibiting higher IL-6 and C-reactive protein (CRP) concentrations with a higher risk of atherosclerotic events (AE).
The occurrence of AE was analyzed with respect to body mass index, IL-6 gene promoter polymorphism at position -174 (G→C), and other relevant risk factors, retrospectively, in 217 renal transplant recipients and, prospectively, in 132.
Circulating IL-6 concentrations were closely related to BMI (r=0.55, P=.0005). In overweight patients, serum IL-6 concentration was found to be significantly lower in C carriers than in GG patients (4.2 [1.0–5.1] versus 7.3 pg/mL [4.4–100]; P=.025). The incidence of AE was higher in overweight GG patients (29.5% versus 10.1%; P=.0003). In multivariate analysis, overweight-GG had an increased risk to develop AE (HR 2.96 [95% CI 1.09–8.04], P=.034 in the retrospective cohort, and HR 2.99 [95% CI 0.92–9.33], P=.069 in the prospective cohort).
All these data are consistent with a role for both genetic and environmental determinants of inflammation (white adipose tissue mass) in the development of AE in renal transplanted patients. |
| format | Article |
| id | doaj-art-78d5921bffc64f67932fa642a0b5bbf7 |
| institution | OA Journals |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-78d5921bffc64f67932fa642a0b5bbf72025-08-20T02:07:30ZengWileyJournal of Transplantation2090-00072090-00152011-01-01201110.1155/2011/803429803429The Interleukin-6 Gene Promoter Polymorphism -174 and Atherosclerotic Events in Overweight Transplanted PatientsJamal Bamoulid0Cécile Courivaud1Marina Deschamps2Béatrice Gaugler3Pierre Tiberghien4Jean-Marc Chalopin5Philippe Saas6Didier Ducloux7INSERM, UMR645, 25020 Besançon, FranceINSERM, UMR645, 25020 Besançon, FranceINSERM, UMR645, 25020 Besançon, FranceINSERM, UMR645, 25020 Besançon, FranceINSERM, UMR645, 25020 Besançon, FranceINSERM, UMR645, 25020 Besançon, FranceINSERM, UMR645, 25020 Besançon, FranceINSERM, UMR645, 25020 Besançon, FranceChronic inflammation plays a pivotal role in atherosclerosis. We hypothesized that combining overweight and a greater genetic capacity to produce IL-6 predicted by IL-6 gene promoter polymorphism at position -174 (G→C) may allow to identify individuals exhibiting higher IL-6 and C-reactive protein (CRP) concentrations with a higher risk of atherosclerotic events (AE). The occurrence of AE was analyzed with respect to body mass index, IL-6 gene promoter polymorphism at position -174 (G→C), and other relevant risk factors, retrospectively, in 217 renal transplant recipients and, prospectively, in 132. Circulating IL-6 concentrations were closely related to BMI (r=0.55, P=.0005). In overweight patients, serum IL-6 concentration was found to be significantly lower in C carriers than in GG patients (4.2 [1.0–5.1] versus 7.3 pg/mL [4.4–100]; P=.025). The incidence of AE was higher in overweight GG patients (29.5% versus 10.1%; P=.0003). In multivariate analysis, overweight-GG had an increased risk to develop AE (HR 2.96 [95% CI 1.09–8.04], P=.034 in the retrospective cohort, and HR 2.99 [95% CI 0.92–9.33], P=.069 in the prospective cohort). All these data are consistent with a role for both genetic and environmental determinants of inflammation (white adipose tissue mass) in the development of AE in renal transplanted patients.http://dx.doi.org/10.1155/2011/803429 |
| spellingShingle | Jamal Bamoulid Cécile Courivaud Marina Deschamps Béatrice Gaugler Pierre Tiberghien Jean-Marc Chalopin Philippe Saas Didier Ducloux The Interleukin-6 Gene Promoter Polymorphism -174 and Atherosclerotic Events in Overweight Transplanted Patients Journal of Transplantation |
| title | The Interleukin-6 Gene Promoter Polymorphism -174 and Atherosclerotic Events in Overweight Transplanted Patients |
| title_full | The Interleukin-6 Gene Promoter Polymorphism -174 and Atherosclerotic Events in Overweight Transplanted Patients |
| title_fullStr | The Interleukin-6 Gene Promoter Polymorphism -174 and Atherosclerotic Events in Overweight Transplanted Patients |
| title_full_unstemmed | The Interleukin-6 Gene Promoter Polymorphism -174 and Atherosclerotic Events in Overweight Transplanted Patients |
| title_short | The Interleukin-6 Gene Promoter Polymorphism -174 and Atherosclerotic Events in Overweight Transplanted Patients |
| title_sort | interleukin 6 gene promoter polymorphism 174 and atherosclerotic events in overweight transplanted patients |
| url | http://dx.doi.org/10.1155/2011/803429 |
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