Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review

Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review

1,2,4-Oxadiazole derivatives, a prominent class of nitrogen-containing heterocycles, have gained considerable attention recently due to their broad spectrum of biological activities. This review focuses on the most recent developments (2018–2024) in the exploration of their therapeutic potential. St...

Full description

Saved in:

Bibliographic Details
Main Authors:	Hussam Elddin Nabeih Khasawneh, Ali Abdulrazzaq Abdulhussein Alrikabi, Amran M. AL-Erjan, Mustafa Jawad Kadham, Raed Fanoukh Aboqader Al-Aouadi, Natrayan Lakshmaiya, Roziyeva Muhayyo, Stefan Bräse, Hadeer M. Farhan
Format:	Article
Language:	English
Published:	Elsevier 2025-05-01
Series:	Results in Chemistry
Subjects:	Oxadiazole Anticancer Anti-inflammatory Antidiabetic Antimicrobial Neurodegenerative diseases
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211715625002541
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Corrigendum to “Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review” [Results Chem. 15 (2025) 102271]
by: Hussam Elddin Nabeih Khasawneh, et al.
Published: (2025-05-01)

Biologically oriented synthesis of medicines (BIODS) based on heterylpoxid 2,5-disubstituted 1,3,4-oxadiazoles (Part 2)
by: Yu. V. Karpenko, et al.
Published: (2021-12-01)

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review
by: Jing-Jing Wang, et al.
Published: (2022-12-01)

A novel thiazole-sulfonamide hybrid molecule as a promising dual tubulin/carbonic anhydrase IX inhibitor with anticancer activity
by: Hussam Elddin Nabeih Khasawneh, et al.
Published: (2025-06-01)

Synthesis, Characterization of some New 1, 3, 4-Oxadiazole derivatives based on 4- amino benzoic acid
by: Baghdad Science Journal
Published: (2016-06-01)

Synthesis and Characterization of some New 1,3,4-Oxadiazole derivatives based on 4-amino benzoic acid
by: Baghdad Science Journal
Published: (2016-12-01)

1,3,4-Oxadiazole derivatives as potent antifungal agents: Synthesis, biological evaluation and an in silico study
by: Quy Nguyen, et al.
Published: (2023-11-01)

1,3,4-Oxadiazole derivatives as potent antifungal agents: Synthesis, biological evaluation and an in silico study
by: Quy Nguyen, et al.
Published: (2023-11-01)

Synthesis of 1,2,4-Oxadiazoles Based on Diffractaic Acid
by: Aleksandr Filimonov, et al.
Published: (2024-11-01)

Preparation, Characterization, of Some Oxadiazol Derivatives Prepared from Different Carboxylic Acids
by: Selvana A. Yousif
Published: (2024-12-01)

Synthesis, Characterization and study biologicalactivity of several 1-cyclopentene-1,2-dicarboxylimidyl Containing oxadiazole and Benzothiazole
by: Baghdad Science Journal
Published: (2014-06-01)

Synthesis, Characterizations, Anti-Diabetic and Molecular Modeling Approaches of Hybrid Indole-Oxadiazole Linked Thiazolidinone Derivatives
by: Shoaib Khan, et al.
Published: (2024-10-01)

Anti-Leukemic Profiling of Oxazole-Linked Oxadiazole Derivatives: A Computational and Kinetic Approach
by: Manal M. Khowdiary, et al.
Published: (2025-04-01)

In vitro antitumor and immunomodulatory activities of 1,2,4-oxadiazole derivatives
by: Héverton Mendes Araújo, et al.
Published: (2025-03-01)

Synthesis and Characterization of 1,3,4-Oxadiazoles Derived From 9-Fluorenone
by: Baghdad Science Journal
Published: (2013-06-01)

Antioxidant evaluation of novel 3-Aryl-5-phenyloxy-1,2,4-oxadiazoles as radical scavengers: Synthesis, characterization, and ADME studies
by: Mohammed Salah Ayoup, et al.
Published: (2025-07-01)

Synthesis and Antifungal Activity of 1,2,4-Oxadiazole Derivatives
by: Lili Yu, et al.
Published: (2025-04-01)

Molecular Docking and In Vitro Studies of Synthesized Oxadiazole Derivatives as Urease Inhibitors
by: Kamran Mehdi, et al.
Published: (2025-08-01)

In vivo anti-inflammatory evaluation of oxadiazole derivatives bearing flurbiprofen moiety using experimental and computational approaches
by: Kosar Shaheen, et al.
Published: (2025-08-01)

Synthesis of graphene-oxadiazole-2-thiol (RGS) / PVA composite and studying Its electric properties
by: Ibrahim F. waheed, et al.
Published: (2023-02-01)

Synthetic Approaches to 1,3,4-Oxadiazole-Containing Boronic Derivatives
by: Barbara Wołek, et al.
Published: (2025-07-01)

In silico design of novel dihydropteridone derivatives with oxadiazoles as potent inhibitors of MCF-7 breast cancer cells
by: Mourad Aloui, et al.
Published: (2025-07-01)

Synthesis and Characterization of 1,3,4- oxadiazole Derivatives using an Ultrasonic Technique
by: Faiq H. Saaid, et al.
Published: (2018-11-01)

Synthesis and characterization Studies of Metal Complexes with Schiff base derived from 4-[5-(2-hydoxy-phenyl)-[1,3,4-oxadiazol-2-ylimino methyl]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one
by: Baghdad Science Journal
Published: (2016-06-01)

Synthesis, X-ray diffraction analysis, quantum chemical studies and α-amylase inhibition of probenecid derived S-alkylphthalimide-oxadiazole-benzenesulfonamide hybrids
by: Bilal Ahmad Khan, et al.
Published: (2022-12-01)

Development of novel 3, 5-substituted-1,2,4-oxadiazole derivatives: a multidimensional approach with in vitro antibacterial, antioxidant, DFT insights, and molecular dynamics simulations
by: Nandeesh Kebbahalli Nagalingaiah, et al.
Published: (2025-07-01)

Exploring 1,3,4-oxadiazole derivatives for hepatocellular carcinoma: synthesis, and bioactivity evaluation
by: Mohini Patidar, et al.
Published: (2025-04-01)

Rational design, and synthesis of imidazole ring incorporated Pyridine-1,2,4-oxadiazole derivatives: In-vitro anticancer evaluation and in-silico molecular docking simulations
by: Rambabu Vasamsetti, et al.
Published: (2025-05-01)

Rh(III)-Catalyzed Double Annulation of 3-Phenyl-1,2,4-oxadiazoles with 2-Diazo-1,3-diketones: Access to Pyran-Fused Isoquinolines
by: Enshen Zhang, et al.
Published: (2025-01-01)

Design, Molecular Docking, Synthesis, Characterization and Preliminary Evaluation of Novel 1,3,4-Oxadiazole Derivatives as Cyclin-Dependent Kinase 2 Inhibitors
by: Yousef Sabah Ali, et al.
Published: (2025-01-01)

A mechanism-driven strategy for in-silico prediction, molecular docking, synthesis, and biological assessment of substituted 1,3,4-oxadiazole derivatives as novel antidiabetic agents
by: Mohini Patidar, et al.
Published: (2025-04-01)

Palladium-catalyzed Suzuki–Miyaura cross-coupling with $\alpha $-aminophosphonates based on 1,3,4-oxadiazole as ligands
by: Hkiri, Shaima, et al.
Published: (2022-02-01)

DFT analysis of the [3 + 2] heterocyclization reaction of ((1,2,4-triazole(1,3,4-oxadiazole)-3(2)-yl)methyl)thiopyrimidines
by: Yu. V. Karpenko
Published: (2025-03-01)

Synthesis and characterization of new metal complexes of thione and phosphines Ligands
by: Ahmed S. M. Al-Janabi, et al.
Published: (2023-02-01)

The study of antiexudative action of S-alkylated 1,3,4-oxadiazole-3-thionе derivatives
by: Yu. L. Shepeta, et al.
Published: (2019-12-01)

C–N coupling for 1,3,4-oxadiazole derivatives using RuPhos PdG4 catalyst: A Novel approach to efficient synthesis
by: Deepak Kumar, et al.
Published: (2025-07-01)

Novel pyridine-1,3,4-oxadiazole linked 1,2,3-triazole hybrids: synthesis, molecular docking, ADME, DFT study and anti-tumor potential
by: Aezaz Mathakiya, et al.
Published: (2025-07-01)

Design and synthesis of new 1,2,3-triazole-methoxyphenyl-1,3,4-oxadiazole derivatives: selective butyrylcholinesterase inhibitors against Alzheimer’s disease
by: Aida Iraji, et al.
Published: (2025-04-01)

EGFR tyrosine kinase inhibitor: design, synthesis, characterization, biological evaluation, and molecular docking of novel 1,3,4-oxadiazole, thio-methyl, and 1,2,3-triazole hybrids
by: Asma Khalaf Alshamari, et al.
Published: (2025-07-01)

Biologically oriented synthesis of medicines (BIODS) based on heterylpoxid 2,5- disubstituted 1,3,4-oxadiazoles (Part 1)
by: Yu. V. Karpenko, et al.
Published: (2020-08-01)