Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review
1,2,4-Oxadiazole derivatives, a prominent class of nitrogen-containing heterocycles, have gained considerable attention recently due to their broad spectrum of biological activities. This review focuses on the most recent developments (2018–2024) in the exploration of their therapeutic potential. St...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715625002541 |
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| author | Hussam Elddin Nabeih Khasawneh Ali Abdulrazzaq Abdulhussein Alrikabi Amran M. AL-Erjan Mustafa Jawad Kadham Raed Fanoukh Aboqader Al-Aouadi Natrayan Lakshmaiya Roziyeva Muhayyo Stefan Bräse Hadeer M. Farhan |
| author_facet | Hussam Elddin Nabeih Khasawneh Ali Abdulrazzaq Abdulhussein Alrikabi Amran M. AL-Erjan Mustafa Jawad Kadham Raed Fanoukh Aboqader Al-Aouadi Natrayan Lakshmaiya Roziyeva Muhayyo Stefan Bräse Hadeer M. Farhan |
| author_sort | Hussam Elddin Nabeih Khasawneh |
| collection | DOAJ |
| description | 1,2,4-Oxadiazole derivatives, a prominent class of nitrogen-containing heterocycles, have gained considerable attention recently due to their broad spectrum of biological activities. This review focuses on the most recent developments (2018–2024) in the exploration of their therapeutic potential. Studies have highlighted the efficacy of 1,2,4-oxadiazole derivatives in multiple domains, including anticancer, antimicrobial, antidiabetic, anti-inflammatory, and neuroprotective applications. These compounds have demonstrated promising results, particularly in combating drug-resistant pathogens, managing metabolic disorders, and offering potential treatments for neurodegenerative diseases. With a growing body of research supporting their diverse biological roles, 1,2,4-oxadiazole derivatives continue to be a significant focus in drug discovery and development. This review compiles key findings from recent studies, offering insights into their therapeutic applications and potential future directions for research. |
| format | Article |
| id | doaj-art-78d0d3c1a65d42beb837781a8caa74c8 |
| institution | OA Journals |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-78d0d3c1a65d42beb837781a8caa74c82025-08-20T02:09:05ZengElsevierResults in Chemistry2211-71562025-05-011510227110.1016/j.rechem.2025.102271Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated reviewHussam Elddin Nabeih Khasawneh0Ali Abdulrazzaq Abdulhussein Alrikabi1Amran M. AL-Erjan2Mustafa Jawad Kadham3Raed Fanoukh Aboqader Al-Aouadi4Natrayan Lakshmaiya5Roziyeva Muhayyo6Stefan Bräse7Hadeer M. Farhan8Chemical Engineering Department, Huson University College, Albalqa Applied University, Salt, JordanCollege of Medicine, University of Thi-Qar, IraqDepartment Of Medical Lab. Technology, Mazaya University College, Dhi Qar, IraqCollege of Medical Techniques, Al-Farahidi University, Baghdad, IraqCollege of Medicine, Al-Ayen Iraqi University, An Nasiriyah, IraqDepartment of Research and Innovation, Saveetha School of Engineering, SIMATS, Chennai 602105, Tamilnadu, IndiaDepartment of Psychology and Medicine, Mamun university, Khiva, UzbekistanInstitute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany; Corresponding authors.Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia, Egypt; Corresponding authors.1,2,4-Oxadiazole derivatives, a prominent class of nitrogen-containing heterocycles, have gained considerable attention recently due to their broad spectrum of biological activities. This review focuses on the most recent developments (2018–2024) in the exploration of their therapeutic potential. Studies have highlighted the efficacy of 1,2,4-oxadiazole derivatives in multiple domains, including anticancer, antimicrobial, antidiabetic, anti-inflammatory, and neuroprotective applications. These compounds have demonstrated promising results, particularly in combating drug-resistant pathogens, managing metabolic disorders, and offering potential treatments for neurodegenerative diseases. With a growing body of research supporting their diverse biological roles, 1,2,4-oxadiazole derivatives continue to be a significant focus in drug discovery and development. This review compiles key findings from recent studies, offering insights into their therapeutic applications and potential future directions for research.http://www.sciencedirect.com/science/article/pii/S2211715625002541OxadiazoleAnticancerAnti-inflammatoryAntidiabeticAntimicrobialNeurodegenerative diseases |
| spellingShingle | Hussam Elddin Nabeih Khasawneh Ali Abdulrazzaq Abdulhussein Alrikabi Amran M. AL-Erjan Mustafa Jawad Kadham Raed Fanoukh Aboqader Al-Aouadi Natrayan Lakshmaiya Roziyeva Muhayyo Stefan Bräse Hadeer M. Farhan Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review Results in Chemistry Oxadiazole Anticancer Anti-inflammatory Antidiabetic Antimicrobial Neurodegenerative diseases |
| title | Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review |
| title_full | Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review |
| title_fullStr | Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review |
| title_full_unstemmed | Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review |
| title_short | Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review |
| title_sort | unveiling the therapeutic potential of 1 2 4 oxadiazole derivatives an updated review |
| topic | Oxadiazole Anticancer Anti-inflammatory Antidiabetic Antimicrobial Neurodegenerative diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2211715625002541 |
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