Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular-Targeting for Androgenic Alopecia Topical Treatment
<b>Background/Objectives:</b> Although androgenic alopecia is the most prevalent among non-cicatricial alopecia, it still lacks an effective and safe treatment. Dutasteride (DUT) shows promising results in hair regrowth; however, oral DUT intake causes serious sexual adverse events. Henc...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/16/12/1524 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850058465923301376 |
|---|---|
| author | Jayanaraian F. M. Andrade Breno N. Matos Rafael V. Rocho Geisa N. Barbalho Marcilio Cunha-Filho Guilherme M. Gelfuso Taís Gratieri |
| author_facet | Jayanaraian F. M. Andrade Breno N. Matos Rafael V. Rocho Geisa N. Barbalho Marcilio Cunha-Filho Guilherme M. Gelfuso Taís Gratieri |
| author_sort | Jayanaraian F. M. Andrade |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> Although androgenic alopecia is the most prevalent among non-cicatricial alopecia, it still lacks an effective and safe treatment. Dutasteride (DUT) shows promising results in hair regrowth; however, oral DUT intake causes serious sexual adverse events. Hence, we produced liposomes with different bilayer structures and evaluated the capability of such systems in increasing DUT accumulation in the hair follicles. <b>Methods:</b> In vitro skin penetration tests were performed with porcine ear skin, and the follicular targeting factor (Tf) was calculated as the ratio between DUT amount in HFs and DUT recovered from the sum of all skin layers. <b>Results:</b> While the stiffer DUT-loaded liposome was not able to target the hair follicles in 12 h (Tf = 0.15), a DUT-loaded liposome with an edge activator in its composition, i.e., transfersomes, promoted better control over DUT release and a higher Tf (0.32) (<i>p</i> < 0.005). <b>Conclusions:</b> Transfersomes present higher affinity with DUT providing a better controlled release; hence, they are a better option for DUT follicle targeting compared to liposomes. Further formulation optimizations are needed aiming to prolong such targeting effect. |
| format | Article |
| id | doaj-art-78c7ef1a68cd476ab18a056e666dc5eb |
| institution | DOAJ |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-78c7ef1a68cd476ab18a056e666dc5eb2025-08-20T02:51:07ZengMDPI AGPharmaceutics1999-49232024-11-011612152410.3390/pharmaceutics16121524Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular-Targeting for Androgenic Alopecia Topical TreatmentJayanaraian F. M. Andrade0Breno N. Matos1Rafael V. Rocho2Geisa N. Barbalho3Marcilio Cunha-Filho4Guilherme M. Gelfuso5Taís Gratieri6Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia (UnB), Brasília 70910-900, DF, BrazilLaboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia (UnB), Brasília 70910-900, DF, BrazilLaboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia (UnB), Brasília 70910-900, DF, BrazilLaboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia (UnB), Brasília 70910-900, DF, BrazilLaboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia (UnB), Brasília 70910-900, DF, BrazilLaboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia (UnB), Brasília 70910-900, DF, BrazilLaboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia (UnB), Brasília 70910-900, DF, Brazil<b>Background/Objectives:</b> Although androgenic alopecia is the most prevalent among non-cicatricial alopecia, it still lacks an effective and safe treatment. Dutasteride (DUT) shows promising results in hair regrowth; however, oral DUT intake causes serious sexual adverse events. Hence, we produced liposomes with different bilayer structures and evaluated the capability of such systems in increasing DUT accumulation in the hair follicles. <b>Methods:</b> In vitro skin penetration tests were performed with porcine ear skin, and the follicular targeting factor (Tf) was calculated as the ratio between DUT amount in HFs and DUT recovered from the sum of all skin layers. <b>Results:</b> While the stiffer DUT-loaded liposome was not able to target the hair follicles in 12 h (Tf = 0.15), a DUT-loaded liposome with an edge activator in its composition, i.e., transfersomes, promoted better control over DUT release and a higher Tf (0.32) (<i>p</i> < 0.005). <b>Conclusions:</b> Transfersomes present higher affinity with DUT providing a better controlled release; hence, they are a better option for DUT follicle targeting compared to liposomes. Further formulation optimizations are needed aiming to prolong such targeting effect.https://www.mdpi.com/1999-4923/16/12/1524androgenic alopeciadutasteridefollicular targetingliposometransfersome |
| spellingShingle | Jayanaraian F. M. Andrade Breno N. Matos Rafael V. Rocho Geisa N. Barbalho Marcilio Cunha-Filho Guilherme M. Gelfuso Taís Gratieri Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular-Targeting for Androgenic Alopecia Topical Treatment Pharmaceutics androgenic alopecia dutasteride follicular targeting liposome transfersome |
| title | Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular-Targeting for Androgenic Alopecia Topical Treatment |
| title_full | Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular-Targeting for Androgenic Alopecia Topical Treatment |
| title_fullStr | Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular-Targeting for Androgenic Alopecia Topical Treatment |
| title_full_unstemmed | Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular-Targeting for Androgenic Alopecia Topical Treatment |
| title_short | Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular-Targeting for Androgenic Alopecia Topical Treatment |
| title_sort | evaluation of dutasteride loaded liposomes and transfersomes for follicular targeting for androgenic alopecia topical treatment |
| topic | androgenic alopecia dutasteride follicular targeting liposome transfersome |
| url | https://www.mdpi.com/1999-4923/16/12/1524 |
| work_keys_str_mv | AT jayanaraianfmandrade evaluationofdutasterideloadedliposomesandtransfersomesforfolliculartargetingforandrogenicalopeciatopicaltreatment AT brenonmatos evaluationofdutasterideloadedliposomesandtransfersomesforfolliculartargetingforandrogenicalopeciatopicaltreatment AT rafaelvrocho evaluationofdutasterideloadedliposomesandtransfersomesforfolliculartargetingforandrogenicalopeciatopicaltreatment AT geisanbarbalho evaluationofdutasterideloadedliposomesandtransfersomesforfolliculartargetingforandrogenicalopeciatopicaltreatment AT marciliocunhafilho evaluationofdutasterideloadedliposomesandtransfersomesforfolliculartargetingforandrogenicalopeciatopicaltreatment AT guilhermemgelfuso evaluationofdutasterideloadedliposomesandtransfersomesforfolliculartargetingforandrogenicalopeciatopicaltreatment AT taisgratieri evaluationofdutasterideloadedliposomesandtransfersomesforfolliculartargetingforandrogenicalopeciatopicaltreatment |