Minimally invasive robotic ureteral reconstruction using endoscopic submucosal dissection harvested colorectal mucosa graft for ureteral stricture
Abstract To evaluate the feasibility and safety of using colorectal mucosal grafts (CMG) harvested via endoscopic submucosal dissection (ESD) for ureteral reconstruction in patients with ureteral stricture. Eight patients with ureteral stricture underwent robotic ureteral reconstruction using CMG ha...
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Nature Portfolio
2025-04-01
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| Online Access: | https://doi.org/10.1038/s41598-025-97826-2 |
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| author | Haihang Nie Yali Yu Xiubing Chen Jingkai Zhou Xianglin Li Yuntian Hong Fan Wang Chaoqi Liang Bing Li Haizhou Wang Hongling Wang Qiu Zhao Jiayan Nie |
| author_facet | Haihang Nie Yali Yu Xiubing Chen Jingkai Zhou Xianglin Li Yuntian Hong Fan Wang Chaoqi Liang Bing Li Haizhou Wang Hongling Wang Qiu Zhao Jiayan Nie |
| author_sort | Haihang Nie |
| collection | DOAJ |
| description | Abstract To evaluate the feasibility and safety of using colorectal mucosal grafts (CMG) harvested via endoscopic submucosal dissection (ESD) for ureteral reconstruction in patients with ureteral stricture. Eight patients with ureteral stricture underwent robotic ureteral reconstruction using CMG harvested by ESD. Preoperative assessments included clinical history, physical examination, and various imaging studies. The ESD procedure was performed with standard precautions to obtain sufficient graft material. Postoperative follow-up involved endoscopic examinations and retrograde pyelograms to assess colorectal complication and ureteral patency. The average age of patients was 44 years, and the median BMI was 24.6 kg/m². The causes of stricture included ureteral stones, urinary tract infections, and ureteral polyps. The median stricture length was 3.5 cm. The average size of the harvested CMG was 4 × 2.4 cm. The success rate of the grafting procedure was 100%, with no gastrointestinal complications observed. Endoscopic examination one week postoperatively revealed well-healed wounds. No recurrent ureteral strictures were noted during a median follow-up period of 5 months. The average glomerular filtration rate (GFR) of the affected kidneys was 61 ml/min. Harvesting CMG via ESD for ureteral reconstruction is feasible and safe, with minimal complications and promising short-term outcomes. This technique provides a viable alternative for patients contraindicated for oral mucosal grafts, potentially reducing morbidity associated with traditional intestinal mucosa harvesting methods. |
| format | Article |
| id | doaj-art-78c2cf7435764b0182db4e50faf0e4e2 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-78c2cf7435764b0182db4e50faf0e4e22025-08-20T02:17:09ZengNature PortfolioScientific Reports2045-23222025-04-011511810.1038/s41598-025-97826-2Minimally invasive robotic ureteral reconstruction using endoscopic submucosal dissection harvested colorectal mucosa graft for ureteral strictureHaihang Nie0Yali Yu1Xiubing Chen2Jingkai Zhou3Xianglin Li4Yuntian Hong5Fan Wang6Chaoqi Liang7Bing Li8Haizhou Wang9Hongling Wang10Qiu Zhao11Jiayan Nie12Department of Gastroenterology, Zhongnan Hospital of Wuhan UniversityDepartment of Gastroenterology, Zhongnan Hospital of Wuhan UniversityDepartment of Gastroenterology, the Fifth Affiliated Hospital of Guangxi Medical UniversityDepartment of Gastroenterology, Zhongnan Hospital of Wuhan UniversityDepartment of Gastroenterology, Zhongnan Hospital of Wuhan UniversityDepartment of Gastroenterology, Zhongnan Hospital of Wuhan UniversityDepartment of Gastroenterology, Zhongnan Hospital of Wuhan UniversityDepartment of Urology, Zhongnan Hospital of Wuhan UniversityDepartment of Urology, Zhongnan Hospital of Wuhan UniversityDepartment of Gastroenterology, Zhongnan Hospital of Wuhan UniversityDepartment of Gastroenterology, Zhongnan Hospital of Wuhan UniversityDepartment of Gastroenterology, Zhongnan Hospital of Wuhan UniversityDepartment of Gastroenterology, Zhongnan Hospital of Wuhan UniversityAbstract To evaluate the feasibility and safety of using colorectal mucosal grafts (CMG) harvested via endoscopic submucosal dissection (ESD) for ureteral reconstruction in patients with ureteral stricture. Eight patients with ureteral stricture underwent robotic ureteral reconstruction using CMG harvested by ESD. Preoperative assessments included clinical history, physical examination, and various imaging studies. The ESD procedure was performed with standard precautions to obtain sufficient graft material. Postoperative follow-up involved endoscopic examinations and retrograde pyelograms to assess colorectal complication and ureteral patency. The average age of patients was 44 years, and the median BMI was 24.6 kg/m². The causes of stricture included ureteral stones, urinary tract infections, and ureteral polyps. The median stricture length was 3.5 cm. The average size of the harvested CMG was 4 × 2.4 cm. The success rate of the grafting procedure was 100%, with no gastrointestinal complications observed. Endoscopic examination one week postoperatively revealed well-healed wounds. No recurrent ureteral strictures were noted during a median follow-up period of 5 months. The average glomerular filtration rate (GFR) of the affected kidneys was 61 ml/min. Harvesting CMG via ESD for ureteral reconstruction is feasible and safe, with minimal complications and promising short-term outcomes. This technique provides a viable alternative for patients contraindicated for oral mucosal grafts, potentially reducing morbidity associated with traditional intestinal mucosa harvesting methods.https://doi.org/10.1038/s41598-025-97826-2Endoscopic submucosal dissectionUreteral reconstructionColorectal mucosa graftUreteral stricture |
| spellingShingle | Haihang Nie Yali Yu Xiubing Chen Jingkai Zhou Xianglin Li Yuntian Hong Fan Wang Chaoqi Liang Bing Li Haizhou Wang Hongling Wang Qiu Zhao Jiayan Nie Minimally invasive robotic ureteral reconstruction using endoscopic submucosal dissection harvested colorectal mucosa graft for ureteral stricture Scientific Reports Endoscopic submucosal dissection Ureteral reconstruction Colorectal mucosa graft Ureteral stricture |
| title | Minimally invasive robotic ureteral reconstruction using endoscopic submucosal dissection harvested colorectal mucosa graft for ureteral stricture |
| title_full | Minimally invasive robotic ureteral reconstruction using endoscopic submucosal dissection harvested colorectal mucosa graft for ureteral stricture |
| title_fullStr | Minimally invasive robotic ureteral reconstruction using endoscopic submucosal dissection harvested colorectal mucosa graft for ureteral stricture |
| title_full_unstemmed | Minimally invasive robotic ureteral reconstruction using endoscopic submucosal dissection harvested colorectal mucosa graft for ureteral stricture |
| title_short | Minimally invasive robotic ureteral reconstruction using endoscopic submucosal dissection harvested colorectal mucosa graft for ureteral stricture |
| title_sort | minimally invasive robotic ureteral reconstruction using endoscopic submucosal dissection harvested colorectal mucosa graft for ureteral stricture |
| topic | Endoscopic submucosal dissection Ureteral reconstruction Colorectal mucosa graft Ureteral stricture |
| url | https://doi.org/10.1038/s41598-025-97826-2 |
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