Glycoconjugates and Related Molecules in Human Vascular Endothelial Cells

Vascular endothelial cells (ECs) form the inner lining of blood vessels. They are critically involved in many physiological functions, including control of vasomotor tone, blood cell trafficking, hemostatic balance, permeability, proliferation, survival, and immunity. It is considered that impairmen...

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Main Authors: Norihiko Sasaki, Masashi Toyoda
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:International Journal of Vascular Medicine
Online Access:http://dx.doi.org/10.1155/2013/963596
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author Norihiko Sasaki
Masashi Toyoda
author_facet Norihiko Sasaki
Masashi Toyoda
author_sort Norihiko Sasaki
collection DOAJ
description Vascular endothelial cells (ECs) form the inner lining of blood vessels. They are critically involved in many physiological functions, including control of vasomotor tone, blood cell trafficking, hemostatic balance, permeability, proliferation, survival, and immunity. It is considered that impairment of EC functions leads to the development of vascular diseases. The carbohydrate antigens carried by glycoconjugates (e.g., glycoproteins, glycosphingolipids, and proteoglycans) mainly present on the cell surface serve not only as marker molecules but also as functional molecules. Recent studies have revealed that the carbohydrate composition of the EC surface is critical for these cells to perform their physiological functions. In this paper, we consider the expression and functional roles of endogenous glycoconjugates and related molecules (galectins and glycan-degrading enzymes) in human ECs.
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publishDate 2013-01-01
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series International Journal of Vascular Medicine
spelling doaj-art-78c103482e3744d39651e201d9d2743f2025-02-03T05:49:56ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322013-01-01201310.1155/2013/963596963596Glycoconjugates and Related Molecules in Human Vascular Endothelial CellsNorihiko Sasaki0Masashi Toyoda1Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, Sakaecho 35-2, Itabashi-ku, Tokyo 173-0015, JapanResearch Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, Sakaecho 35-2, Itabashi-ku, Tokyo 173-0015, JapanVascular endothelial cells (ECs) form the inner lining of blood vessels. They are critically involved in many physiological functions, including control of vasomotor tone, blood cell trafficking, hemostatic balance, permeability, proliferation, survival, and immunity. It is considered that impairment of EC functions leads to the development of vascular diseases. The carbohydrate antigens carried by glycoconjugates (e.g., glycoproteins, glycosphingolipids, and proteoglycans) mainly present on the cell surface serve not only as marker molecules but also as functional molecules. Recent studies have revealed that the carbohydrate composition of the EC surface is critical for these cells to perform their physiological functions. In this paper, we consider the expression and functional roles of endogenous glycoconjugates and related molecules (galectins and glycan-degrading enzymes) in human ECs.http://dx.doi.org/10.1155/2013/963596
spellingShingle Norihiko Sasaki
Masashi Toyoda
Glycoconjugates and Related Molecules in Human Vascular Endothelial Cells
International Journal of Vascular Medicine
title Glycoconjugates and Related Molecules in Human Vascular Endothelial Cells
title_full Glycoconjugates and Related Molecules in Human Vascular Endothelial Cells
title_fullStr Glycoconjugates and Related Molecules in Human Vascular Endothelial Cells
title_full_unstemmed Glycoconjugates and Related Molecules in Human Vascular Endothelial Cells
title_short Glycoconjugates and Related Molecules in Human Vascular Endothelial Cells
title_sort glycoconjugates and related molecules in human vascular endothelial cells
url http://dx.doi.org/10.1155/2013/963596
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AT masashitoyoda glycoconjugatesandrelatedmoleculesinhumanvascularendothelialcells