Glycoconjugates and Related Molecules in Human Vascular Endothelial Cells
Vascular endothelial cells (ECs) form the inner lining of blood vessels. They are critically involved in many physiological functions, including control of vasomotor tone, blood cell trafficking, hemostatic balance, permeability, proliferation, survival, and immunity. It is considered that impairmen...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/963596 |
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| _version_ | 1832554964810989568 |
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| author | Norihiko Sasaki Masashi Toyoda |
| author_facet | Norihiko Sasaki Masashi Toyoda |
| author_sort | Norihiko Sasaki |
| collection | DOAJ |
| description | Vascular endothelial cells (ECs) form the inner lining of blood vessels. They are critically involved in many physiological functions, including control of vasomotor tone, blood cell trafficking, hemostatic balance, permeability, proliferation, survival, and immunity. It is considered that impairment of EC functions leads to the development of vascular diseases. The carbohydrate antigens carried by glycoconjugates (e.g., glycoproteins, glycosphingolipids, and proteoglycans) mainly present on the cell surface serve not only as marker molecules but also as functional molecules. Recent studies have revealed that the carbohydrate composition of the EC surface is critical for these cells to perform their physiological functions. In this paper, we consider the expression and functional roles of endogenous glycoconjugates and related molecules (galectins and glycan-degrading enzymes) in human ECs. |
| format | Article |
| id | doaj-art-78c103482e3744d39651e201d9d2743f |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-78c103482e3744d39651e201d9d2743f2025-02-03T05:49:56ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322013-01-01201310.1155/2013/963596963596Glycoconjugates and Related Molecules in Human Vascular Endothelial CellsNorihiko Sasaki0Masashi Toyoda1Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, Sakaecho 35-2, Itabashi-ku, Tokyo 173-0015, JapanResearch Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, Sakaecho 35-2, Itabashi-ku, Tokyo 173-0015, JapanVascular endothelial cells (ECs) form the inner lining of blood vessels. They are critically involved in many physiological functions, including control of vasomotor tone, blood cell trafficking, hemostatic balance, permeability, proliferation, survival, and immunity. It is considered that impairment of EC functions leads to the development of vascular diseases. The carbohydrate antigens carried by glycoconjugates (e.g., glycoproteins, glycosphingolipids, and proteoglycans) mainly present on the cell surface serve not only as marker molecules but also as functional molecules. Recent studies have revealed that the carbohydrate composition of the EC surface is critical for these cells to perform their physiological functions. In this paper, we consider the expression and functional roles of endogenous glycoconjugates and related molecules (galectins and glycan-degrading enzymes) in human ECs.http://dx.doi.org/10.1155/2013/963596 |
| spellingShingle | Norihiko Sasaki Masashi Toyoda Glycoconjugates and Related Molecules in Human Vascular Endothelial Cells International Journal of Vascular Medicine |
| title | Glycoconjugates and Related Molecules in Human Vascular Endothelial Cells |
| title_full | Glycoconjugates and Related Molecules in Human Vascular Endothelial Cells |
| title_fullStr | Glycoconjugates and Related Molecules in Human Vascular Endothelial Cells |
| title_full_unstemmed | Glycoconjugates and Related Molecules in Human Vascular Endothelial Cells |
| title_short | Glycoconjugates and Related Molecules in Human Vascular Endothelial Cells |
| title_sort | glycoconjugates and related molecules in human vascular endothelial cells |
| url | http://dx.doi.org/10.1155/2013/963596 |
| work_keys_str_mv | AT norihikosasaki glycoconjugatesandrelatedmoleculesinhumanvascularendothelialcells AT masashitoyoda glycoconjugatesandrelatedmoleculesinhumanvascularendothelialcells |