Activation of FGFR genes by genetic and epigenetic alterations in uterine leiomyomas

Activation of FGFR genes by genetic and epigenetic alterations in uterine leiomyomas

Abstract Background Fibroblast growth factor 1-4 (FGFR1-4) are well-known oncogenic drivers in many cancer types. Here, we studied the role of FGFRs in uterine leiomyoma (UL) that is a benign neoplasm arising from the myometrium and the most common tumour in women. Although ULs can be classified to...

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Main Authors: Vilja Jokinen, Aurora Taira, Åsa Kolterud, Isa Ahlgren, Kimmo Palin, Riku Katainen, Maritta Räisänen, Eevi Kaasinen, Sini Ilves, Anniina Raitila, Helena Kopp Kallner, Emma Siili, Ralf Bützow, Oskari Heikinheimo, Annukka Pasanen, Auli Karhu, Niko Välimäki, Lauri A. Aaltonen
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:BJC Reports
Online Access:https://doi.org/10.1038/s44276-025-00127-4
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