Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings
Our objective was to evaluate outcomes in patients with sustained viral suppression compared to those with episodes of viremia. Methods. In a prospective cohort of patients started on ART in Uganda and followed for 48 months, patients were categorized according to viral load (VL): (1) sustained-supp...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2011/736938 |
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| author | Barbara Castelnuovo Joseph Sempa Kiragga N. Agnes Moses R. Kamya Yukari C. Manabe |
| author_facet | Barbara Castelnuovo Joseph Sempa Kiragga N. Agnes Moses R. Kamya Yukari C. Manabe |
| author_sort | Barbara Castelnuovo |
| collection | DOAJ |
| description | Our objective was to evaluate outcomes in patients with sustained viral suppression compared to those with episodes of viremia. Methods. In a prospective cohort of patients started on ART in Uganda and followed for 48 months, patients were categorized according to viral load (VL): (1) sustained-suppression: (VL ≤1,000 copies/mL) (2) VL 1,001–10,000, or (3) VL >10,000. Results. Fifty-Three (11.2%) and 84 (17.8%) patients had a first episode of intermediate and high viremia, respectively. Patients with sustained suppression had better CD4+ T cell count increases over time compared to viremic patients (𝑃<.001). The majority of patients with viremia achieved viral suppression when the measurement was repeated. Only 39.6% of patients with intermediate and 19.1% with high viremia eventually needed to be switched to second line (𝑃=.008). Conclusions. The use of at least one repeat measurement rather than a single VL measurement could avert from 60% to 80% of unnecessary switches. |
| format | Article |
| id | doaj-art-78bdbeaf124542619dbb76e0d5d72cf6 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-78bdbeaf124542619dbb76e0d5d72cf62025-02-03T06:13:44ZengWileyAIDS Research and Treatment2090-12402090-12592011-01-01201110.1155/2011/736938736938Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited SettingsBarbara Castelnuovo0Joseph Sempa1Kiragga N. Agnes2Moses R. Kamya3Yukari C. Manabe4Infectious Diseases Institute, Makerere University, Mulago Hospital Complex, P.O. Box 22418, Kampala, UgandaInfectious Diseases Institute, Makerere University, Mulago Hospital Complex, P.O. Box 22418, Kampala, UgandaInfectious Diseases Institute, Makerere University, Mulago Hospital Complex, P.O. Box 22418, Kampala, UgandaDepartment of Medicine, Makerere University College of Health Sciences, Kampala, UgandaInfectious Diseases Institute, Makerere University, Mulago Hospital Complex, P.O. Box 22418, Kampala, UgandaOur objective was to evaluate outcomes in patients with sustained viral suppression compared to those with episodes of viremia. Methods. In a prospective cohort of patients started on ART in Uganda and followed for 48 months, patients were categorized according to viral load (VL): (1) sustained-suppression: (VL ≤1,000 copies/mL) (2) VL 1,001–10,000, or (3) VL >10,000. Results. Fifty-Three (11.2%) and 84 (17.8%) patients had a first episode of intermediate and high viremia, respectively. Patients with sustained suppression had better CD4+ T cell count increases over time compared to viremic patients (𝑃<.001). The majority of patients with viremia achieved viral suppression when the measurement was repeated. Only 39.6% of patients with intermediate and 19.1% with high viremia eventually needed to be switched to second line (𝑃=.008). Conclusions. The use of at least one repeat measurement rather than a single VL measurement could avert from 60% to 80% of unnecessary switches.http://dx.doi.org/10.1155/2011/736938 |
| spellingShingle | Barbara Castelnuovo Joseph Sempa Kiragga N. Agnes Moses R. Kamya Yukari C. Manabe Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings AIDS Research and Treatment |
| title | Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings |
| title_full | Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings |
| title_fullStr | Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings |
| title_full_unstemmed | Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings |
| title_short | Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings |
| title_sort | evaluation of who criteria for viral failure in patients on antiretroviral treatment in resource limited settings |
| url | http://dx.doi.org/10.1155/2011/736938 |
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