Ultrasensitive circular dichroism spectroscopy based on coupled quasi-bound states in the continuum
Circular dichroism (CD) spectroscopy is essential for biochemistry, structural biology and pharmaceutical chemistry. While the chiroptical properties of chiral molecules are characterized by the Pasteur parameter κ, it is commonly conceived that the generation of CD is solely attributed to the imagi...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-01-01
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| Series: | Nanophotonics |
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| Online Access: | https://doi.org/10.1515/nanoph-2024-0620 |
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| _version_ | 1850143155751485440 |
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| author | Guan Tingting Wang Zhenyu Wang Ruize Wu Zihan Wang Chaowei Wu Dong Chu Jiaru Chen Yang |
| author_facet | Guan Tingting Wang Zhenyu Wang Ruize Wu Zihan Wang Chaowei Wu Dong Chu Jiaru Chen Yang |
| author_sort | Guan Tingting |
| collection | DOAJ |
| description | Circular dichroism (CD) spectroscopy is essential for biochemistry, structural biology and pharmaceutical chemistry. While the chiroptical properties of chiral molecules are characterized by the Pasteur parameter κ, it is commonly conceived that the generation of CD is solely attributed to the imaginary part κ′′. However, since the imaginary part κ′′ is orders of magnitude smaller than the real part κ′ for most chiral molecules, the achievable sensitivity of CD spectroscopy is quite limited. Here, we report a recipe for realizing ultrasensitive CD spectroscopy based on the κ′ component of chiral molecules. Two quasi-bound states in the continuum are coupled by chiral molecules to form two hybridized branches, whose wavelengths and eigenpolarizations are very sensitive to the value of κ′. Giant CD signals over four orders of magnitude larger than the case without mode coupling are thus produced, paving the way towards chiral structure analysis at the single molecule level. |
| format | Article |
| id | doaj-art-78bd987cebea49fd92f7c5b4f575d1b2 |
| institution | OA Journals |
| issn | 2192-8614 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Nanophotonics |
| spelling | doaj-art-78bd987cebea49fd92f7c5b4f575d1b22025-08-20T02:28:49ZengDe GruyterNanophotonics2192-86142025-01-011481083108910.1515/nanoph-2024-0620Ultrasensitive circular dichroism spectroscopy based on coupled quasi-bound states in the continuumGuan Tingting0Wang Zhenyu1Wang Ruize2Wu Zihan3Wang Chaowei4Wu Dong5Chu Jiaru6Chen Yang7Chinese Academy of Sciences Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, 12652University of Science and Technology of China, 230027Hefei, ChinaChinese Academy of Sciences Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, 12652University of Science and Technology of China, 230027Hefei, ChinaChinese Academy of Sciences Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, 12652University of Science and Technology of China, 230027Hefei, ChinaChinese Academy of Sciences Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, 12652University of Science and Technology of China, 230027Hefei, ChinaChinese Academy of Sciences Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, 12652University of Science and Technology of China, 230027Hefei, ChinaChinese Academy of Sciences Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, 12652University of Science and Technology of China, 230027Hefei, ChinaChinese Academy of Sciences Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, 12652University of Science and Technology of China, 230027Hefei, ChinaChinese Academy of Sciences Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, 12652University of Science and Technology of China, 230027Hefei, ChinaCircular dichroism (CD) spectroscopy is essential for biochemistry, structural biology and pharmaceutical chemistry. While the chiroptical properties of chiral molecules are characterized by the Pasteur parameter κ, it is commonly conceived that the generation of CD is solely attributed to the imaginary part κ′′. However, since the imaginary part κ′′ is orders of magnitude smaller than the real part κ′ for most chiral molecules, the achievable sensitivity of CD spectroscopy is quite limited. Here, we report a recipe for realizing ultrasensitive CD spectroscopy based on the κ′ component of chiral molecules. Two quasi-bound states in the continuum are coupled by chiral molecules to form two hybridized branches, whose wavelengths and eigenpolarizations are very sensitive to the value of κ′. Giant CD signals over four orders of magnitude larger than the case without mode coupling are thus produced, paving the way towards chiral structure analysis at the single molecule level.https://doi.org/10.1515/nanoph-2024-0620cd spectroscopychiral sensingmode couplingbound state in the continuum |
| spellingShingle | Guan Tingting Wang Zhenyu Wang Ruize Wu Zihan Wang Chaowei Wu Dong Chu Jiaru Chen Yang Ultrasensitive circular dichroism spectroscopy based on coupled quasi-bound states in the continuum Nanophotonics cd spectroscopy chiral sensing mode coupling bound state in the continuum |
| title | Ultrasensitive circular dichroism spectroscopy based on coupled quasi-bound states in the continuum |
| title_full | Ultrasensitive circular dichroism spectroscopy based on coupled quasi-bound states in the continuum |
| title_fullStr | Ultrasensitive circular dichroism spectroscopy based on coupled quasi-bound states in the continuum |
| title_full_unstemmed | Ultrasensitive circular dichroism spectroscopy based on coupled quasi-bound states in the continuum |
| title_short | Ultrasensitive circular dichroism spectroscopy based on coupled quasi-bound states in the continuum |
| title_sort | ultrasensitive circular dichroism spectroscopy based on coupled quasi bound states in the continuum |
| topic | cd spectroscopy chiral sensing mode coupling bound state in the continuum |
| url | https://doi.org/10.1515/nanoph-2024-0620 |
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