Rebamipide during chronic gastritis: <i>H. pylori</i> eradication therapy and restoration of gastric mucosa barrier function
Аim: to present evidence justifying prescription of rebamipide during chronic gastritis.Key points. Experimental and clinical studies have demonstrated that rebamipide increases concentration of prostaglandins (prostaglandin E2 and prostacyclin) and production of mucin, manages inflammation and oxid...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2024-01-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/940 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860052473151488 |
|---|---|
| author | Т. L. Lapina V. T. Ivashkin |
| author_facet | Т. L. Lapina V. T. Ivashkin |
| author_sort | Т. L. Lapina |
| collection | DOAJ |
| description | Аim: to present evidence justifying prescription of rebamipide during chronic gastritis.Key points. Experimental and clinical studies have demonstrated that rebamipide increases concentration of prostaglandins (prostaglandin E2 and prostacyclin) and production of mucin, manages inflammation and oxidative stress, controls apoptosis and autophagy. Pleiotropic effects of rebamipide are aimed at restoration of epithelium barrier function and can be implemented during chronic gastritis for various indications. When added to the H. pylori eradication therapy, rebamipide increases its effectiveness and tolerability. During atrophic gastritis, long-term treatment with rebamipide has resulted in reduction of degree of atrophy and intestinal metaplasia. Effectiveness of rebamipide during erosive gastritis, for treatment and prevention of stomach and duodenum disorders associated with nonste- roidal anti-inflammatory drugs is proven. Rebamipide manages symptoms of dyspepsia during chronic gastritis and during functional dyspepsia.Conclusion. Prescription of rebamipide during chronic gastritis for various indications is proved from the perspective of evidence-based medicine during H. pylori eradication therapy and for restoration of mucosa barrier function. |
| format | Article |
| id | doaj-art-78bd262750c3432794a594ddeec3a8d1 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-78bd262750c3432794a594ddeec3a8d12025-02-10T16:14:38ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732024-01-01336818710.22416/1382-4376-2023-33-6-81-87586Rebamipide during chronic gastritis: <i>H. pylori</i> eradication therapy and restoration of gastric mucosa barrier functionТ. L. Lapina0V. T. Ivashkin1I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)Аim: to present evidence justifying prescription of rebamipide during chronic gastritis.Key points. Experimental and clinical studies have demonstrated that rebamipide increases concentration of prostaglandins (prostaglandin E2 and prostacyclin) and production of mucin, manages inflammation and oxidative stress, controls apoptosis and autophagy. Pleiotropic effects of rebamipide are aimed at restoration of epithelium barrier function and can be implemented during chronic gastritis for various indications. When added to the H. pylori eradication therapy, rebamipide increases its effectiveness and tolerability. During atrophic gastritis, long-term treatment with rebamipide has resulted in reduction of degree of atrophy and intestinal metaplasia. Effectiveness of rebamipide during erosive gastritis, for treatment and prevention of stomach and duodenum disorders associated with nonste- roidal anti-inflammatory drugs is proven. Rebamipide manages symptoms of dyspepsia during chronic gastritis and during functional dyspepsia.Conclusion. Prescription of rebamipide during chronic gastritis for various indications is proved from the perspective of evidence-based medicine during H. pylori eradication therapy and for restoration of mucosa barrier function.https://www.gastro-j.ru/jour/article/view/940chronic gastritis<i>helicobacter pylori</i>rebamipide<i>h. pylori</i> eradication therapyerosive gastritisdyspepsia |
| spellingShingle | Т. L. Lapina V. T. Ivashkin Rebamipide during chronic gastritis: <i>H. pylori</i> eradication therapy and restoration of gastric mucosa barrier function Российский журнал гастроэнтерологии, гепатологии, колопроктологии chronic gastritis <i>helicobacter pylori</i> rebamipide <i>h. pylori</i> eradication therapy erosive gastritis dyspepsia |
| title | Rebamipide during chronic gastritis: <i>H. pylori</i> eradication therapy and restoration of gastric mucosa barrier function |
| title_full | Rebamipide during chronic gastritis: <i>H. pylori</i> eradication therapy and restoration of gastric mucosa barrier function |
| title_fullStr | Rebamipide during chronic gastritis: <i>H. pylori</i> eradication therapy and restoration of gastric mucosa barrier function |
| title_full_unstemmed | Rebamipide during chronic gastritis: <i>H. pylori</i> eradication therapy and restoration of gastric mucosa barrier function |
| title_short | Rebamipide during chronic gastritis: <i>H. pylori</i> eradication therapy and restoration of gastric mucosa barrier function |
| title_sort | rebamipide during chronic gastritis i h pylori i eradication therapy and restoration of gastric mucosa barrier function |
| topic | chronic gastritis <i>helicobacter pylori</i> rebamipide <i>h. pylori</i> eradication therapy erosive gastritis dyspepsia |
| url | https://www.gastro-j.ru/jour/article/view/940 |
| work_keys_str_mv | AT tllapina rebamipideduringchronicgastritisihpyloriieradicationtherapyandrestorationofgastricmucosabarrierfunction AT vtivashkin rebamipideduringchronicgastritisihpyloriieradicationtherapyandrestorationofgastricmucosabarrierfunction |