Drosophila model of HPV18-Induced pathogenesis reveals a role for E6 oncogene in regulation of NF-κB and Wnt to inhibit apoptosis

Drosophila model of HPV18-Induced pathogenesis reveals a role for E6 oncogene in regulation of NF-κB and Wnt to inhibit apoptosis

Cancers caused by high-risk human papillomavirus (HPV) remain a significant health threat resulting in more than 300,000 deaths, annually. Persistent expression of two HPV oncogenes, E6 and E7, are necessary for cancer development and progression. E6 has several functions contributing to tumorigenes...

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Bibliographic Details
Main Authors: Mojgan Padash Barmchi, Rami N. Hassan, Mehrnaz Afkhami, John P. Masly, Harrison Brown, Quincy P. Collins, Michael J. Grunsted
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Tumour Virus Research
Subjects:
Drosophila
HPV
E6
Apoptosis
NF-κB
Wingless
Online Access:http://www.sciencedirect.com/science/article/pii/S2666679025000047
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