Mechanisms and Prevention Strategies of Macrophage Involvement in the Progression From Hypertension to Heart Failure
Hypertensive heart disease, a condition affecting millions worldwide, encompasses a spectrum from uncontrolled hypertension to heart failure. Despite the intricacies of its pathogenic mechanisms, recent attention has been directed toward the role of macrophages in the progression from hypertension t...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/ijhy/2618127 |
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| author | Ningning Zhang Pengyu Cao Bojian Wang Jinting Yang Lijing Zhao Wangshu Shao |
| author_facet | Ningning Zhang Pengyu Cao Bojian Wang Jinting Yang Lijing Zhao Wangshu Shao |
| author_sort | Ningning Zhang |
| collection | DOAJ |
| description | Hypertensive heart disease, a condition affecting millions worldwide, encompasses a spectrum from uncontrolled hypertension to heart failure. Despite the intricacies of its pathogenic mechanisms, recent attention has been directed toward the role of macrophages in the progression from hypertension to heart failure. Under normal circumstances, macrophages contribute to tissue homeostasis by clearing deceased cells. However, dysregulation during hypertension triggers inflammatory pathways, leading to tissue damage. Oxidative stress and mitochondrial dysfunction are implicated in this process. Exercise training, gaining popularity for its potential in regulating macrophage function, emerges as a promising intervention to improve outcomes in hypertensive heart disease. This review provides a succinct overview of previous research elucidating the involvement of macrophages in the transition from hypertension to heart failure. It underscores the current active areas of investigation and emphasizes the potential of exercise training in mediating macrophage responses, offering a glimpse into a hopeful avenue for therapeutic intervention in this challenging medical condition. |
| format | Article |
| id | doaj-art-78aa84044b6342f29b3d169902f69fed |
| institution | OA Journals |
| issn | 2090-0392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-78aa84044b6342f29b3d169902f69fed2025-08-20T02:34:55ZengWileyInternational Journal of Hypertension2090-03922025-01-01202510.1155/ijhy/2618127Mechanisms and Prevention Strategies of Macrophage Involvement in the Progression From Hypertension to Heart FailureNingning Zhang0Pengyu Cao1Bojian Wang2Jinting Yang3Lijing Zhao4Wangshu Shao5The Cardiovascular CenterThe Cardiovascular CenterSchool of NursingSchool of NursingSchool of NursingThe Cardiovascular CenterHypertensive heart disease, a condition affecting millions worldwide, encompasses a spectrum from uncontrolled hypertension to heart failure. Despite the intricacies of its pathogenic mechanisms, recent attention has been directed toward the role of macrophages in the progression from hypertension to heart failure. Under normal circumstances, macrophages contribute to tissue homeostasis by clearing deceased cells. However, dysregulation during hypertension triggers inflammatory pathways, leading to tissue damage. Oxidative stress and mitochondrial dysfunction are implicated in this process. Exercise training, gaining popularity for its potential in regulating macrophage function, emerges as a promising intervention to improve outcomes in hypertensive heart disease. This review provides a succinct overview of previous research elucidating the involvement of macrophages in the transition from hypertension to heart failure. It underscores the current active areas of investigation and emphasizes the potential of exercise training in mediating macrophage responses, offering a glimpse into a hopeful avenue for therapeutic intervention in this challenging medical condition.http://dx.doi.org/10.1155/ijhy/2618127 |
| spellingShingle | Ningning Zhang Pengyu Cao Bojian Wang Jinting Yang Lijing Zhao Wangshu Shao Mechanisms and Prevention Strategies of Macrophage Involvement in the Progression From Hypertension to Heart Failure International Journal of Hypertension |
| title | Mechanisms and Prevention Strategies of Macrophage Involvement in the Progression From Hypertension to Heart Failure |
| title_full | Mechanisms and Prevention Strategies of Macrophage Involvement in the Progression From Hypertension to Heart Failure |
| title_fullStr | Mechanisms and Prevention Strategies of Macrophage Involvement in the Progression From Hypertension to Heart Failure |
| title_full_unstemmed | Mechanisms and Prevention Strategies of Macrophage Involvement in the Progression From Hypertension to Heart Failure |
| title_short | Mechanisms and Prevention Strategies of Macrophage Involvement in the Progression From Hypertension to Heart Failure |
| title_sort | mechanisms and prevention strategies of macrophage involvement in the progression from hypertension to heart failure |
| url | http://dx.doi.org/10.1155/ijhy/2618127 |
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