Identification and heterologous expression of an NRPS biosynthetic gene cluster responsible for the production of the pyrazinones Ichizinone A, B and C

Identification and heterologous expression of an NRPS biosynthetic gene cluster responsible for the production of the pyrazinones Ichizinone A, B and C

Abstract Pyrazinones are a growing family of microbial NRPS-derived natural products showing interesting biological activities. These compounds are characterized by the presence of either a di- or trisubstituted heterocyclic, nonaromatic 2(1 H)-pyrazinone core in their structure. The most commonly o...

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Bibliographic Details
Main Authors: Patrick Oberhäuser, Maksym Myronovskyi, Marc Stierhof, Oleksandr Gromyko, Andriy Luzhetskyy
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Microbial Cell Factories
Subjects:
Actinobacteria
Streptomyces
Pyrazinone
NRPS
Heterologous expression
Gene cluster
Online Access:https://doi.org/10.1186/s12934-025-02753-6
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