Comparison between intratympanic injection of dexamethasone and methylprednisolone in idiopathic sudden sensorineural hearing loss: A randomized clinical trial
Abstract Objective To compare the hearing outcomes of patients with idiopathic sudden sensorineural hearing loss after intratympanic (IT) injection of methylprednisolone and dexamethasone. Study design Randomized case‐controlled clinical trial. Methods Seventy‐five patients diagnosed with idiopathic...
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Wiley
2024-12-01
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| Series: | Laryngoscope Investigative Otolaryngology |
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| Online Access: | https://doi.org/10.1002/lio2.70054 |
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| author | Kourosh Eftekharian Elnaz Najafi Maryam Amizadeh Noosheen Mokari Mohammad Faramarzi Yalda Izadparast Yalda Jabbari Moghadam Ali Eftekharian |
| author_facet | Kourosh Eftekharian Elnaz Najafi Maryam Amizadeh Noosheen Mokari Mohammad Faramarzi Yalda Izadparast Yalda Jabbari Moghadam Ali Eftekharian |
| author_sort | Kourosh Eftekharian |
| collection | DOAJ |
| description | Abstract Objective To compare the hearing outcomes of patients with idiopathic sudden sensorineural hearing loss after intratympanic (IT) injection of methylprednisolone and dexamethasone. Study design Randomized case‐controlled clinical trial. Methods Seventy‐five patients diagnosed with idiopathic sensorineural hearing loss were randomly divided into two groups based on therapy. Both groups received oral prednisolone (10 mg/kg; maximum of 60 mg) for 10 days without tapering and received IT injections two times a week for 2 weeks (four injections in total). One group received an IT injection of a 40 mg/mL solution of methylprednisolone, and the other one, 4 mg/mL dexamethasone. Three comparisons between the initial and third‐month hearing tests were made to assess the degree of hearing change: (1) pure tone improvement in each individual tone (0.5, 1, 2, 3, and 4 kHz); (2) word‐recognition score improvement; and (3) complete, partial, and no recovery of hearing calculated (as defined by American Academy of Otolaryngology‐Head and Neck Surgery Clinical Practice Guidelines). Results The study was completed with 69 of the 75 patients—34 in the methylprednisolone group and 35 in the dexamethasone group. The groups' differences in frequency‐specific hearing improvement were not statistically significant. There was no statistically significant difference in the word recognition score improvement between the two groups. Additionally, there was no discernible difference between the two groups' hearing recovery rates. Conclusion Methylprednisolone and dexamethasone IT injection therapy had similar hearing outcomes. Level of evidence 2. |
| format | Article |
| id | doaj-art-78a6faed380348cb8e49a18fd77b457c |
| institution | OA Journals |
| issn | 2378-8038 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj-art-78a6faed380348cb8e49a18fd77b457c2025-08-20T01:59:53ZengWileyLaryngoscope Investigative Otolaryngology2378-80382024-12-0196n/an/a10.1002/lio2.70054Comparison between intratympanic injection of dexamethasone and methylprednisolone in idiopathic sudden sensorineural hearing loss: A randomized clinical trialKourosh Eftekharian0Elnaz Najafi1Maryam Amizadeh2Noosheen Mokari3Mohammad Faramarzi4Yalda Izadparast5Yalda Jabbari Moghadam6Ali Eftekharian7Hearing Disorders Research Center, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences Tehran IranHearing Disorders Research Center, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences Tehran IranDepartment of Otorhinolaryngology Kerman University of Medical Sciences Kerman IranHearing Disorders Research Center, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences Tehran IranOtolaryngology Research Center, Department of Otolaryngology Shiraz University of Medical Sciences Shiraz IranDepartment of Otolaryngology Tehran University of Medical Sciences IranDepartment of Otorhinolaryngology, School of Medicine, Sina Medical Research and Training Hospital, Children Medical Research and Training Hospital Tabriz University of Medical Sciences Tabriz IranHearing Disorders Research Center, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences Tehran IranAbstract Objective To compare the hearing outcomes of patients with idiopathic sudden sensorineural hearing loss after intratympanic (IT) injection of methylprednisolone and dexamethasone. Study design Randomized case‐controlled clinical trial. Methods Seventy‐five patients diagnosed with idiopathic sensorineural hearing loss were randomly divided into two groups based on therapy. Both groups received oral prednisolone (10 mg/kg; maximum of 60 mg) for 10 days without tapering and received IT injections two times a week for 2 weeks (four injections in total). One group received an IT injection of a 40 mg/mL solution of methylprednisolone, and the other one, 4 mg/mL dexamethasone. Three comparisons between the initial and third‐month hearing tests were made to assess the degree of hearing change: (1) pure tone improvement in each individual tone (0.5, 1, 2, 3, and 4 kHz); (2) word‐recognition score improvement; and (3) complete, partial, and no recovery of hearing calculated (as defined by American Academy of Otolaryngology‐Head and Neck Surgery Clinical Practice Guidelines). Results The study was completed with 69 of the 75 patients—34 in the methylprednisolone group and 35 in the dexamethasone group. The groups' differences in frequency‐specific hearing improvement were not statistically significant. There was no statistically significant difference in the word recognition score improvement between the two groups. Additionally, there was no discernible difference between the two groups' hearing recovery rates. Conclusion Methylprednisolone and dexamethasone IT injection therapy had similar hearing outcomes. Level of evidence 2.https://doi.org/10.1002/lio2.70054dexamethasoneintratympanic injectionmethylprednisolonerandomized controlled trialsteroidsudden sensorineural hearing loss |
| spellingShingle | Kourosh Eftekharian Elnaz Najafi Maryam Amizadeh Noosheen Mokari Mohammad Faramarzi Yalda Izadparast Yalda Jabbari Moghadam Ali Eftekharian Comparison between intratympanic injection of dexamethasone and methylprednisolone in idiopathic sudden sensorineural hearing loss: A randomized clinical trial Laryngoscope Investigative Otolaryngology dexamethasone intratympanic injection methylprednisolone randomized controlled trial steroid sudden sensorineural hearing loss |
| title | Comparison between intratympanic injection of dexamethasone and methylprednisolone in idiopathic sudden sensorineural hearing loss: A randomized clinical trial |
| title_full | Comparison between intratympanic injection of dexamethasone and methylprednisolone in idiopathic sudden sensorineural hearing loss: A randomized clinical trial |
| title_fullStr | Comparison between intratympanic injection of dexamethasone and methylprednisolone in idiopathic sudden sensorineural hearing loss: A randomized clinical trial |
| title_full_unstemmed | Comparison between intratympanic injection of dexamethasone and methylprednisolone in idiopathic sudden sensorineural hearing loss: A randomized clinical trial |
| title_short | Comparison between intratympanic injection of dexamethasone and methylprednisolone in idiopathic sudden sensorineural hearing loss: A randomized clinical trial |
| title_sort | comparison between intratympanic injection of dexamethasone and methylprednisolone in idiopathic sudden sensorineural hearing loss a randomized clinical trial |
| topic | dexamethasone intratympanic injection methylprednisolone randomized controlled trial steroid sudden sensorineural hearing loss |
| url | https://doi.org/10.1002/lio2.70054 |
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