Prospects and Challenges of the Drug Delivery Systems in Endometriosis Pain Management: Experimental and Theoretical Aspects
Endometriosis is considered a serious public health issue because of the large number of females affected by this illness. Chronic pain management in patients with endometriosis demands new strategies to increase the life quality of these patients. The development of drug delivery systems represents...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/2727174 |
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| author | Bogdan Florin Toma Razvan Socolov Ovidiu Popa Demetra Socolov Irina Nica Maricel Agop Decebal Vasincu Mihaela Grigore Lacramioara Ochiuz |
| author_facet | Bogdan Florin Toma Razvan Socolov Ovidiu Popa Demetra Socolov Irina Nica Maricel Agop Decebal Vasincu Mihaela Grigore Lacramioara Ochiuz |
| author_sort | Bogdan Florin Toma |
| collection | DOAJ |
| description | Endometriosis is considered a serious public health issue because of the large number of females affected by this illness. Chronic pain management in patients with endometriosis demands new strategies to increase the life quality of these patients. The development of drug delivery systems represents a new approach in pain treatment among endometriosis patients. Diclofenac sodium, one of the most utilized nonsteroidal anti-inflammatory drugs (NSAID), has its own limitations when being used in formulas such as oral, parental, or local applications. In this paper, a series of four drug release formulations based on chitosan, 2-hydroxy-5-nitrobenzaldehyde, and diclofenac sodium salt were prepared in view of the investigation of the drug release ability. The formulations were analyzed from a morphological and supramolecular point of view by scanning electron microscopy and polarized light microscopy. The in vitro drug release ability was investigated by mimicking a physiologic environment. A mathematical model, using the fractal paradigm of motion, is utilized to explain the behaviors of the drug delivery system presented in this paper. These results suggest a great potential of the proposed drug delivery system, based on chitosan and 2-hydroxy-5-nitrobenzaldehyde to improve the diclofenac sodium salt bioavailability, and it may represent a future treatment formula for endometriosis pain. |
| format | Article |
| id | doaj-art-78a353088014465eafc5d1d4f68ee5cc |
| institution | OA Journals |
| issn | 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-78a353088014465eafc5d1d4f68ee5cc2025-08-20T02:07:31ZengWileyJournal of Immunology Research2314-71562021-01-01202110.1155/2021/2727174Prospects and Challenges of the Drug Delivery Systems in Endometriosis Pain Management: Experimental and Theoretical AspectsBogdan Florin Toma0Razvan Socolov1Ovidiu Popa2Demetra Socolov3Irina Nica4Maricel Agop5Decebal Vasincu6Mihaela Grigore7Lacramioara Ochiuz8“Grigore T. Popa” University of Medicine and PharmacyDepartment of Obstetrics and GynecologyDepartment of Emergency MedicineDepartment of Obstetrics and GynecologyDepartment of OdontologyDepartment of PhysicsDepartment of Dental and Oro-Maxillo-Facial SurgeryDepartment of Obstetrics and GynecologyDepartment of Pharmaceutical and Biotechnological Drug IndustryEndometriosis is considered a serious public health issue because of the large number of females affected by this illness. Chronic pain management in patients with endometriosis demands new strategies to increase the life quality of these patients. The development of drug delivery systems represents a new approach in pain treatment among endometriosis patients. Diclofenac sodium, one of the most utilized nonsteroidal anti-inflammatory drugs (NSAID), has its own limitations when being used in formulas such as oral, parental, or local applications. In this paper, a series of four drug release formulations based on chitosan, 2-hydroxy-5-nitrobenzaldehyde, and diclofenac sodium salt were prepared in view of the investigation of the drug release ability. The formulations were analyzed from a morphological and supramolecular point of view by scanning electron microscopy and polarized light microscopy. The in vitro drug release ability was investigated by mimicking a physiologic environment. A mathematical model, using the fractal paradigm of motion, is utilized to explain the behaviors of the drug delivery system presented in this paper. These results suggest a great potential of the proposed drug delivery system, based on chitosan and 2-hydroxy-5-nitrobenzaldehyde to improve the diclofenac sodium salt bioavailability, and it may represent a future treatment formula for endometriosis pain.http://dx.doi.org/10.1155/2021/2727174 |
| spellingShingle | Bogdan Florin Toma Razvan Socolov Ovidiu Popa Demetra Socolov Irina Nica Maricel Agop Decebal Vasincu Mihaela Grigore Lacramioara Ochiuz Prospects and Challenges of the Drug Delivery Systems in Endometriosis Pain Management: Experimental and Theoretical Aspects Journal of Immunology Research |
| title | Prospects and Challenges of the Drug Delivery Systems in Endometriosis Pain Management: Experimental and Theoretical Aspects |
| title_full | Prospects and Challenges of the Drug Delivery Systems in Endometriosis Pain Management: Experimental and Theoretical Aspects |
| title_fullStr | Prospects and Challenges of the Drug Delivery Systems in Endometriosis Pain Management: Experimental and Theoretical Aspects |
| title_full_unstemmed | Prospects and Challenges of the Drug Delivery Systems in Endometriosis Pain Management: Experimental and Theoretical Aspects |
| title_short | Prospects and Challenges of the Drug Delivery Systems in Endometriosis Pain Management: Experimental and Theoretical Aspects |
| title_sort | prospects and challenges of the drug delivery systems in endometriosis pain management experimental and theoretical aspects |
| url | http://dx.doi.org/10.1155/2021/2727174 |
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