Prognostic relevance of sarcopenia and tumor‐infiltrating CD8+ T cells in patients with hepatocellular carcinoma
Abstract Aim The relationship between sarcopenia, tumor‐infiltrating lymphocytes (TILs), and long‐term survival in patients with hepatocellular carcinoma (HCC) has not been investigated. We aimed to evaluate the prognostic relevance of sarcopenia and TILs in patients with HCC. Methods We included 35...
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| Format: | Article |
| Language: | English |
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Wiley
2025-03-01
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| Series: | Annals of Gastroenterological Surgery |
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| Online Access: | https://doi.org/10.1002/ags3.12875 |
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| author | Shunsuke Doi Satoshi Yasuda Miu Miyashita Minako Nagai Kota Nakamura Yasuko Matsuo Taichi Terai Yuichiro Kohara Takeshi Sakata Masayuki Sho |
| author_facet | Shunsuke Doi Satoshi Yasuda Miu Miyashita Minako Nagai Kota Nakamura Yasuko Matsuo Taichi Terai Yuichiro Kohara Takeshi Sakata Masayuki Sho |
| author_sort | Shunsuke Doi |
| collection | DOAJ |
| description | Abstract Aim The relationship between sarcopenia, tumor‐infiltrating lymphocytes (TILs), and long‐term survival in patients with hepatocellular carcinoma (HCC) has not been investigated. We aimed to evaluate the prognostic relevance of sarcopenia and TILs in patients with HCC. Methods We included 351 patients with HCC following liver resection. Sarcopenia was defined based on the skeletal muscle index using computed tomography. Tumor‐infiltrating CD4+ and CD8+ T cells, perforin, and granzyme B were examined in liver resection specimens. Results Sarcopenia patients had a significantly lower lymphocyte count (p = 0.003), prognostic nutritional index (p = 0.017), and CD4+ and CD8+ T cell counts (p = 0.008 and p = 0.006, respectively). The overall survival (OS) and recurrence‐free survival (RFS) rates of sarcopenia patients were significantly lower than non‐sarcopenia patients (both p < 0.001). Multivariate analysis revealed that sarcopenia and low CD8 levels were strong independent poor prognostic factors for OS and RFS (both p < 0.001). Regardless of sarcopenia, patients with high CD8 levels had significantly better OS and RFS rates and increased expression of perforin and granzyme B. Particularly, sarcopenia patients with high CD8 levels had much better OS and RFS than those with low CD8 levels and were even comparable to non‐sarcopenia patients with high CD8 levels. Conclusions Sarcopenia and low CD8 levels are strong independent poor prognostic factors in patients with HCC. Furthermore, sarcopenia patients with high CD8 levels had favorable survival and activated local immunity, suggesting that tumor‐infiltrating CD8+ T cells may play a functionally important role in sarcopenia patients. |
| format | Article |
| id | doaj-art-78a165341f03411e98dc11deb88af2ee |
| institution | DOAJ |
| issn | 2475-0328 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Gastroenterological Surgery |
| spelling | doaj-art-78a165341f03411e98dc11deb88af2ee2025-08-20T03:16:24ZengWileyAnnals of Gastroenterological Surgery2475-03282025-03-019235936810.1002/ags3.12875Prognostic relevance of sarcopenia and tumor‐infiltrating CD8+ T cells in patients with hepatocellular carcinomaShunsuke Doi0Satoshi Yasuda1Miu Miyashita2Minako Nagai3Kota Nakamura4Yasuko Matsuo5Taichi Terai6Yuichiro Kohara7Takeshi Sakata8Masayuki Sho9Department of Surgery Nara Medical University Nara JapanDepartment of Surgery Nara Medical University Nara JapanDepartment of Surgery Nara Medical University Nara JapanDepartment of Surgery Nara Medical University Nara JapanDepartment of Surgery Nara Medical University Nara JapanDepartment of Surgery Nara Medical University Nara JapanDepartment of Surgery Nara Medical University Nara JapanDepartment of Surgery Nara Medical University Nara JapanDepartment of Surgery Nara Medical University Nara JapanDepartment of Surgery Nara Medical University Nara JapanAbstract Aim The relationship between sarcopenia, tumor‐infiltrating lymphocytes (TILs), and long‐term survival in patients with hepatocellular carcinoma (HCC) has not been investigated. We aimed to evaluate the prognostic relevance of sarcopenia and TILs in patients with HCC. Methods We included 351 patients with HCC following liver resection. Sarcopenia was defined based on the skeletal muscle index using computed tomography. Tumor‐infiltrating CD4+ and CD8+ T cells, perforin, and granzyme B were examined in liver resection specimens. Results Sarcopenia patients had a significantly lower lymphocyte count (p = 0.003), prognostic nutritional index (p = 0.017), and CD4+ and CD8+ T cell counts (p = 0.008 and p = 0.006, respectively). The overall survival (OS) and recurrence‐free survival (RFS) rates of sarcopenia patients were significantly lower than non‐sarcopenia patients (both p < 0.001). Multivariate analysis revealed that sarcopenia and low CD8 levels were strong independent poor prognostic factors for OS and RFS (both p < 0.001). Regardless of sarcopenia, patients with high CD8 levels had significantly better OS and RFS rates and increased expression of perforin and granzyme B. Particularly, sarcopenia patients with high CD8 levels had much better OS and RFS than those with low CD8 levels and were even comparable to non‐sarcopenia patients with high CD8 levels. Conclusions Sarcopenia and low CD8 levels are strong independent poor prognostic factors in patients with HCC. Furthermore, sarcopenia patients with high CD8 levels had favorable survival and activated local immunity, suggesting that tumor‐infiltrating CD8+ T cells may play a functionally important role in sarcopenia patients.https://doi.org/10.1002/ags3.12875CD8+ T cellshepatocellular carcinomaliver resectionsarcopeniatumor‐infiltrating lymphocytes |
| spellingShingle | Shunsuke Doi Satoshi Yasuda Miu Miyashita Minako Nagai Kota Nakamura Yasuko Matsuo Taichi Terai Yuichiro Kohara Takeshi Sakata Masayuki Sho Prognostic relevance of sarcopenia and tumor‐infiltrating CD8+ T cells in patients with hepatocellular carcinoma Annals of Gastroenterological Surgery CD8+ T cells hepatocellular carcinoma liver resection sarcopenia tumor‐infiltrating lymphocytes |
| title | Prognostic relevance of sarcopenia and tumor‐infiltrating CD8+ T cells in patients with hepatocellular carcinoma |
| title_full | Prognostic relevance of sarcopenia and tumor‐infiltrating CD8+ T cells in patients with hepatocellular carcinoma |
| title_fullStr | Prognostic relevance of sarcopenia and tumor‐infiltrating CD8+ T cells in patients with hepatocellular carcinoma |
| title_full_unstemmed | Prognostic relevance of sarcopenia and tumor‐infiltrating CD8+ T cells in patients with hepatocellular carcinoma |
| title_short | Prognostic relevance of sarcopenia and tumor‐infiltrating CD8+ T cells in patients with hepatocellular carcinoma |
| title_sort | prognostic relevance of sarcopenia and tumor infiltrating cd8 t cells in patients with hepatocellular carcinoma |
| topic | CD8+ T cells hepatocellular carcinoma liver resection sarcopenia tumor‐infiltrating lymphocytes |
| url | https://doi.org/10.1002/ags3.12875 |
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