Comparison of Tensile Strength of Fibrin Glue, 2-Octyl Cyanoacrylate, Liquid Ocular Bandage, and Conventional Nylon 10-0 Sutures in Corneal Laceration Repair in an Animal Model
Objective: To compare the tensile strength of fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage to conventional nylon 10-0 sutures in sealing central linear corneal lacerations. Methods: An experimental in-vitro study was performed on 74 porcine eyes. A 27-gauge needle connected to an...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Philippine Academy of Ophthalmology
2012-06-01
|
| Series: | Philippine Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://paojournal.com/index.php/pjo/article/view/258 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850095627541676032 |
|---|---|
| author | Sweet Jorlene T. Lerit, MD Jessica Marie R. Abaño, MD |
| author_facet | Sweet Jorlene T. Lerit, MD Jessica Marie R. Abaño, MD |
| author_sort | Sweet Jorlene T. Lerit, MD |
| collection | DOAJ |
| description | Objective: To compare the tensile strength of fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage to conventional nylon 10-0 sutures in sealing central linear corneal lacerations.
Methods: An experimental in-vitro study was performed on 74 porcine eyes. A 27-gauge needle connected to an infusion system with balanced salt solution was inserted into the anterior chamber and the bottle height was adjusted accordingly. Full-thickness central corneal lacerations were created using a 3.2 mm keratome knife for the initial incision and enlarged by a 5.2 mm knife. The wounds were sealed with fibrin glue (Tisseel®), 2-octyl cyanoacrylate (Dermabond®), liquid ocular bandage (OcuSeal™), and nylon 10-0 with 3 sutures. Tensile strength of the wounds was measured by recording the bottle height above the level of the porcine eyes before leakage was detected and this was converted to IOP values. One-way ANOVA and post hoc t-test were used to analyze the data.
Results: Mean maximum IOP where leakage was resisted for the nylon 10-0 suture group was 52.37 ± 7.16 mm Hg. The mean maximum resisted IOP for the fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage was 46.34 ± 12.64 mm Hg, 55.13 ± 10.46 mm Hg, and 56.99 ± 8.27 mm Hg respectively. There was no significant difference between the sutures and all of the adhesives groups (p=0.08, p=0.34, and p=0.08) and between 2-octyl cyanoacrylate and liquid ocular bandage (p=0.57). 2-Octyl cyanoacrylate and liquid ocular bandage demonstrated higher mean IOP as compared to the fibrin group (p = 0.024 and p = 0.007).
Conclusion: Fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage were shown to be effective in sealin 5.2 mm linear corneal lacerations, with 2-octyl cyanoacrylate and liquid ocular bandage being superior to the fibrin glue. |
| format | Article |
| id | doaj-art-78a109c3d0124a85aae2a80b4d117655 |
| institution | DOAJ |
| issn | 0031-7659 |
| language | English |
| publishDate | 2012-06-01 |
| publisher | Philippine Academy of Ophthalmology |
| record_format | Article |
| series | Philippine Journal of Ophthalmology |
| spelling | doaj-art-78a109c3d0124a85aae2a80b4d1176552025-08-20T02:41:24ZengPhilippine Academy of OphthalmologyPhilippine Journal of Ophthalmology0031-76592012-06-013715258258Comparison of Tensile Strength of Fibrin Glue, 2-Octyl Cyanoacrylate, Liquid Ocular Bandage, and Conventional Nylon 10-0 Sutures in Corneal Laceration Repair in an Animal ModelSweet Jorlene T. Lerit, MD0Jessica Marie R. Abaño, MD1DOH Eye Center Department of Ophthalmology East Avenue Medical Center East Avenue, Diliman, Quezon CityDOH Eye Center Department of Ophthalmology East Avenue Medical Center East Avenue, Diliman, Quezon City; Department of Ophthalmology University of Santo Tomas Hospital Manila, PhilippinesObjective: To compare the tensile strength of fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage to conventional nylon 10-0 sutures in sealing central linear corneal lacerations. Methods: An experimental in-vitro study was performed on 74 porcine eyes. A 27-gauge needle connected to an infusion system with balanced salt solution was inserted into the anterior chamber and the bottle height was adjusted accordingly. Full-thickness central corneal lacerations were created using a 3.2 mm keratome knife for the initial incision and enlarged by a 5.2 mm knife. The wounds were sealed with fibrin glue (Tisseel®), 2-octyl cyanoacrylate (Dermabond®), liquid ocular bandage (OcuSeal™), and nylon 10-0 with 3 sutures. Tensile strength of the wounds was measured by recording the bottle height above the level of the porcine eyes before leakage was detected and this was converted to IOP values. One-way ANOVA and post hoc t-test were used to analyze the data. Results: Mean maximum IOP where leakage was resisted for the nylon 10-0 suture group was 52.37 ± 7.16 mm Hg. The mean maximum resisted IOP for the fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage was 46.34 ± 12.64 mm Hg, 55.13 ± 10.46 mm Hg, and 56.99 ± 8.27 mm Hg respectively. There was no significant difference between the sutures and all of the adhesives groups (p=0.08, p=0.34, and p=0.08) and between 2-octyl cyanoacrylate and liquid ocular bandage (p=0.57). 2-Octyl cyanoacrylate and liquid ocular bandage demonstrated higher mean IOP as compared to the fibrin group (p = 0.024 and p = 0.007). Conclusion: Fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage were shown to be effective in sealin 5.2 mm linear corneal lacerations, with 2-octyl cyanoacrylate and liquid ocular bandage being superior to the fibrin glue.https://paojournal.com/index.php/pjo/article/view/258corneal lacerationtissue adhesivestensile strength2-octyl cyanoacrylatefibrin glueliquid ocular bandage |
| spellingShingle | Sweet Jorlene T. Lerit, MD Jessica Marie R. Abaño, MD Comparison of Tensile Strength of Fibrin Glue, 2-Octyl Cyanoacrylate, Liquid Ocular Bandage, and Conventional Nylon 10-0 Sutures in Corneal Laceration Repair in an Animal Model Philippine Journal of Ophthalmology corneal laceration tissue adhesives tensile strength 2-octyl cyanoacrylate fibrin glue liquid ocular bandage |
| title | Comparison of Tensile Strength of Fibrin Glue, 2-Octyl Cyanoacrylate, Liquid Ocular Bandage, and Conventional Nylon 10-0 Sutures in Corneal Laceration Repair in an Animal Model |
| title_full | Comparison of Tensile Strength of Fibrin Glue, 2-Octyl Cyanoacrylate, Liquid Ocular Bandage, and Conventional Nylon 10-0 Sutures in Corneal Laceration Repair in an Animal Model |
| title_fullStr | Comparison of Tensile Strength of Fibrin Glue, 2-Octyl Cyanoacrylate, Liquid Ocular Bandage, and Conventional Nylon 10-0 Sutures in Corneal Laceration Repair in an Animal Model |
| title_full_unstemmed | Comparison of Tensile Strength of Fibrin Glue, 2-Octyl Cyanoacrylate, Liquid Ocular Bandage, and Conventional Nylon 10-0 Sutures in Corneal Laceration Repair in an Animal Model |
| title_short | Comparison of Tensile Strength of Fibrin Glue, 2-Octyl Cyanoacrylate, Liquid Ocular Bandage, and Conventional Nylon 10-0 Sutures in Corneal Laceration Repair in an Animal Model |
| title_sort | comparison of tensile strength of fibrin glue 2 octyl cyanoacrylate liquid ocular bandage and conventional nylon 10 0 sutures in corneal laceration repair in an animal model |
| topic | corneal laceration tissue adhesives tensile strength 2-octyl cyanoacrylate fibrin glue liquid ocular bandage |
| url | https://paojournal.com/index.php/pjo/article/view/258 |
| work_keys_str_mv | AT sweetjorlenetleritmd comparisonoftensilestrengthoffibringlue2octylcyanoacrylateliquidocularbandageandconventionalnylon100suturesincorneallacerationrepairinananimalmodel AT jessicamarierabanomd comparisonoftensilestrengthoffibringlue2octylcyanoacrylateliquidocularbandageandconventionalnylon100suturesincorneallacerationrepairinananimalmodel |