Single-cell analysis identifies PLK1 as a driver of immunosuppressive tumor microenvironment in LUAD.

Single-cell analysis identifies PLK1 as a driver of immunosuppressive tumor microenvironment in LUAD.

PLK1 (Polo-like kinase 1) plays a critical role in the progression of lung adenocarcinoma (LUAD). Recent studies have unveiled that targeting PLK1 improves the efficacy of immunotherapy, highlighting its important role in the regulation of tumor immunity. Nevertheless, our understanding of the intri...

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Main Authors: Yifan Kong, Chaohao Li, Jinpeng Liu, Sai Wu, Min Zhang, Derek B Allison, Faisal Hassan, Daheng He, Xinyi Wang, Fengyi Mao, Qiongsi Zhang, Yanquan Zhang, Zhiguo Li, Chi Wang, Xiaoqi Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-06-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011309
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