GDNF overexpression in astrocytes enhances branching and partially preserves hippocampal function in an Alzheimer’s rat model

GDNF overexpression in astrocytes enhances branching and partially preserves hippocampal function in an Alzheimer’s rat model

Abstract Astrocytes are essential for maintaining neuronal health and regulating the brain’s inflammatory environment. In this study, we developed an adeno-associated viral vector (AAV9) designed to selectively overexpress glial cell line-derived neurotrophic factor (GDNF) in astrocytes, using the a...

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Bibliographic Details
Main Authors: Ana Abril Vidal Escobedo, Facundo Peralta, Gustavo Ramón Morel, Martino Avallone, Tomas Björklund, Paula Cecilia Reggiani, Joaquín Pardo
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Astrocytes
GDNF
Hippocampus
AAV9
Neurodegeneration
Online Access:https://doi.org/10.1038/s41598-025-02881-4
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