Tumor secretome shapes the immune landscape during cancer progression
Abstract The focus of cancer immunotherapy has traditionally been on immune cells and tumor cells themselves, often overlooking the tumor secretome. This review provides a comprehensive overview of the intricate relationship between tumor cells and the immune response in cancer progression. It highl...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
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| Online Access: | https://doi.org/10.1186/s13046-025-03302-0 |
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| author | Jianqiang Yang Sijia Tang Nabil F. Saba Chloe Shay Yong Teng |
| author_facet | Jianqiang Yang Sijia Tang Nabil F. Saba Chloe Shay Yong Teng |
| author_sort | Jianqiang Yang |
| collection | DOAJ |
| description | Abstract The focus of cancer immunotherapy has traditionally been on immune cells and tumor cells themselves, often overlooking the tumor secretome. This review provides a comprehensive overview of the intricate relationship between tumor cells and the immune response in cancer progression. It highlights the pivotal role of the tumor secretome - a diverse set of molecules secreted by tumor cells - in significantly influencing immune modulation, promoting immunosuppression, and facilitating tumor survival. In addition to elucidating these complex interactions, this review discusses current clinical trials targeting the tumor secretome and highlights their potential to advance personalized medicine strategies. These trials aim to overcome the challenges of the tumor microenvironment by designing therapies tailored to the secretome profiles of individual cancer patients. In addition, advances in proteomic techniques are highlighted as essential tools for unraveling the complexity of the tumor secretome, paving the way for improved cancer treatment outcomes. |
| format | Article |
| id | doaj-art-789d7bac7eaf4bc487c4b03544a63032 |
| institution | DOAJ |
| issn | 1756-9966 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj-art-789d7bac7eaf4bc487c4b03544a630322025-08-20T02:43:15ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662025-02-0144111410.1186/s13046-025-03302-0Tumor secretome shapes the immune landscape during cancer progressionJianqiang Yang0Sijia Tang1Nabil F. Saba2Chloe Shay3Yong Teng4Department of Hematology and Medical Oncology, Emory UniversityDepartment of Hematology and Medical Oncology, Emory UniversityDepartment of Hematology and Medical Oncology, Emory UniversityWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory UniversityDepartment of Hematology and Medical Oncology, Emory UniversityAbstract The focus of cancer immunotherapy has traditionally been on immune cells and tumor cells themselves, often overlooking the tumor secretome. This review provides a comprehensive overview of the intricate relationship between tumor cells and the immune response in cancer progression. It highlights the pivotal role of the tumor secretome - a diverse set of molecules secreted by tumor cells - in significantly influencing immune modulation, promoting immunosuppression, and facilitating tumor survival. In addition to elucidating these complex interactions, this review discusses current clinical trials targeting the tumor secretome and highlights their potential to advance personalized medicine strategies. These trials aim to overcome the challenges of the tumor microenvironment by designing therapies tailored to the secretome profiles of individual cancer patients. In addition, advances in proteomic techniques are highlighted as essential tools for unraveling the complexity of the tumor secretome, paving the way for improved cancer treatment outcomes.https://doi.org/10.1186/s13046-025-03302-0Tumor secretomeTumor microenvironmentTumor-immune cell interplayImmunotherapyBiomarkers |
| spellingShingle | Jianqiang Yang Sijia Tang Nabil F. Saba Chloe Shay Yong Teng Tumor secretome shapes the immune landscape during cancer progression Journal of Experimental & Clinical Cancer Research Tumor secretome Tumor microenvironment Tumor-immune cell interplay Immunotherapy Biomarkers |
| title | Tumor secretome shapes the immune landscape during cancer progression |
| title_full | Tumor secretome shapes the immune landscape during cancer progression |
| title_fullStr | Tumor secretome shapes the immune landscape during cancer progression |
| title_full_unstemmed | Tumor secretome shapes the immune landscape during cancer progression |
| title_short | Tumor secretome shapes the immune landscape during cancer progression |
| title_sort | tumor secretome shapes the immune landscape during cancer progression |
| topic | Tumor secretome Tumor microenvironment Tumor-immune cell interplay Immunotherapy Biomarkers |
| url | https://doi.org/10.1186/s13046-025-03302-0 |
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