Disorders of Adipose Tissue and Lipodystrophies: Causes, Consequences, and Treatment Perspectives
Lipodystrophies are rare metabolic disorders characterized by the loss of adipose tissue, which can manifest as generalized, partial, or localized. This condition is associated with metabolic complications such as insulin resistance, diabetes, hypertriglyceridemia, and liver steatosis. The paper di...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-02-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/58194 |
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| author | Rosińska Kamila Rosińska Ewelina Justyna Janicka Julia Natalia Skibicka Monika Niedźwiedzka Mateusz Rosiński |
| author_facet | Rosińska Kamila Rosińska Ewelina Justyna Janicka Julia Natalia Skibicka Monika Niedźwiedzka Mateusz Rosiński |
| author_sort | Rosińska Kamila Rosińska |
| collection | DOAJ |
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Lipodystrophies are rare metabolic disorders characterized by the loss of adipose tissue, which can manifest as generalized, partial, or localized. This condition is associated with metabolic complications such as insulin resistance, diabetes, hypertriglyceridemia, and liver steatosis. The paper discusses the classification of lipodystrophies by etiology and fat loss extent, including generalized and partial forms, both congenital and acquired. Special focus is placed on HIV-associated lipodystrophy due to the prevalence of antiretroviral therapy. The pathophysiology involves disrupted adipogenesis, leading to abnormal fat distribution and metabolic dysfunction. Diagnosis includes medical history, physical exams, and body composition analysis. Treatment focuses on managing metabolic issues and may involve therapies like metreleptin.
OBJECTIVE:
This study aims to analyze the pathophysiology, diagnosis, and treatment of lipodystrophies, particularly focusing on congenital, acquired, and HIV-associated forms. It explores the underlying metabolic mechanisms, diagnostic challenges, and current and future therapeutic approaches, including metreleptin and other strategies.
MATERIALS AND METHODS:
The study relies on scientific research, review articles, and reports on lipodystrophy syndromes, primarily sourced from PubMed, Google Scholar, and Cochrane Library. It examines data related to diagnostics, etiology, and treatment options.
CONCLUSIONS:
Lipodystrophies are rare and heterogeneous, making diagnosis challenging. Early detection is essential to prevent complications like diabetes and cardiovascular disease. Modern technologies such as dual-energy X-ray absorptiometry (DEXA) help assess body composition more accurately. Although therapies like metreleptin show promise, they remain expensive and difficult to implement. Further research is needed to improve understanding and management of lipodystrophies, and patient education is crucial for better outcomes.
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| format | Article |
| id | doaj-art-7899f606db7b44c29ed6afdd8c5608d2 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-7899f606db7b44c29ed6afdd8c5608d22025-02-12T08:26:13ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-02-013810.12775/QS.2025.38.58194Disorders of Adipose Tissue and Lipodystrophies: Causes, Consequences, and Treatment PerspectivesRosińska Kamila Rosińska0https://orcid.org/0009-0001-8158-2051Ewelina Justyna Janicka1https://orcid.org/0009-0006-5139-1728Julia Natalia Skibicka2https://orcid.org/0009-0000-1832-2938Monika Niedźwiedzka3https://orcid.org/0009-0004-9952-3414Mateusz Rosiński4https://orcid.org/0009-0009-6193-8282Voivodeship Integrated Hospital of Jędrzej Śniadecki in BialystokCOPERNICUS Medical Entity Sp. z o. o. Nowe Ogrody 1-6, 80-803 Gdańsk, Poland Grochowski Hospital, Grenadierów 51/59, 04-073 Warsaw, PolandMedical University of Bialystok, Jana Kilińskiego 1, 15-089 Białystok, PolandMedical University of Bialystok, Jana Kilińskiego 1, 15-089 Białystok, Poland Lipodystrophies are rare metabolic disorders characterized by the loss of adipose tissue, which can manifest as generalized, partial, or localized. This condition is associated with metabolic complications such as insulin resistance, diabetes, hypertriglyceridemia, and liver steatosis. The paper discusses the classification of lipodystrophies by etiology and fat loss extent, including generalized and partial forms, both congenital and acquired. Special focus is placed on HIV-associated lipodystrophy due to the prevalence of antiretroviral therapy. The pathophysiology involves disrupted adipogenesis, leading to abnormal fat distribution and metabolic dysfunction. Diagnosis includes medical history, physical exams, and body composition analysis. Treatment focuses on managing metabolic issues and may involve therapies like metreleptin. OBJECTIVE: This study aims to analyze the pathophysiology, diagnosis, and treatment of lipodystrophies, particularly focusing on congenital, acquired, and HIV-associated forms. It explores the underlying metabolic mechanisms, diagnostic challenges, and current and future therapeutic approaches, including metreleptin and other strategies. MATERIALS AND METHODS: The study relies on scientific research, review articles, and reports on lipodystrophy syndromes, primarily sourced from PubMed, Google Scholar, and Cochrane Library. It examines data related to diagnostics, etiology, and treatment options. CONCLUSIONS: Lipodystrophies are rare and heterogeneous, making diagnosis challenging. Early detection is essential to prevent complications like diabetes and cardiovascular disease. Modern technologies such as dual-energy X-ray absorptiometry (DEXA) help assess body composition more accurately. Although therapies like metreleptin show promise, they remain expensive and difficult to implement. Further research is needed to improve understanding and management of lipodystrophies, and patient education is crucial for better outcomes. https://apcz.umk.pl/QS/article/view/58194Lipodystrophyadipose tissue lossmetabolisminsulin resistancediabeteshypertriglyceridemia |
| spellingShingle | Rosińska Kamila Rosińska Ewelina Justyna Janicka Julia Natalia Skibicka Monika Niedźwiedzka Mateusz Rosiński Disorders of Adipose Tissue and Lipodystrophies: Causes, Consequences, and Treatment Perspectives Quality in Sport Lipodystrophy adipose tissue loss metabolism insulin resistance diabetes hypertriglyceridemia |
| title | Disorders of Adipose Tissue and Lipodystrophies: Causes, Consequences, and Treatment Perspectives |
| title_full | Disorders of Adipose Tissue and Lipodystrophies: Causes, Consequences, and Treatment Perspectives |
| title_fullStr | Disorders of Adipose Tissue and Lipodystrophies: Causes, Consequences, and Treatment Perspectives |
| title_full_unstemmed | Disorders of Adipose Tissue and Lipodystrophies: Causes, Consequences, and Treatment Perspectives |
| title_short | Disorders of Adipose Tissue and Lipodystrophies: Causes, Consequences, and Treatment Perspectives |
| title_sort | disorders of adipose tissue and lipodystrophies causes consequences and treatment perspectives |
| topic | Lipodystrophy adipose tissue loss metabolism insulin resistance diabetes hypertriglyceridemia |
| url | https://apcz.umk.pl/QS/article/view/58194 |
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