Targeted Immunotherapy with Rituximab Leads to a Transient Alteration of the IgG Autoantibody Profile in Pemphigus Vulgaris

Targeted Immunotherapy with Rituximab Leads to a Transient Alteration of the IgG Autoantibody Profile in Pemphigus Vulgaris

In pemphigus vulgaris (PV), IgG autoantibodies against the ectodomain of desmoglein 3 (Dsg3) have been shown to be directly responsible for the loss of keratinocyteadhesion. The aim of the present study was to study the effect of the B cell depleting anti-CD20 monoclonal antibody, rituximab, on the...

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Bibliographic Details
Main Authors: Ralf Müller, Nicolas Hunzelmann, Vera Baur, Guido Siebenhaar, Elke Wenzel, Rüdiger Eming, Andrea Niedermeier, Philippe Musette, Pascal Joly, Michael Hertl
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Dermatology Research and Practice
Online Access:http://dx.doi.org/10.1155/2010/321950
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