99mTc-Hynic-TOC imaging in the diagnostic of neuroendocrine tumors
The aim of this study was to assess the potential of 99mTc-Hynic-TOC imaging in the primary diagnosis and follow-up of midgut neuroendocrine tumors (NETs). In comparison to 111In-octreotide, 99mTc-Hynic-TOC has a higher imaging quality and leads to a lower radiation absorption in patients. 99mTc-Hyn...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2018-07-01
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| Series: | World Journal of Nuclear Medicine |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_41_17 |
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| author | Knut Liepe Andreas Becker |
| author_facet | Knut Liepe Andreas Becker |
| author_sort | Knut Liepe |
| collection | DOAJ |
| description | The aim of this study was to assess the potential of 99mTc-Hynic-TOC imaging in the primary diagnosis and follow-up of midgut neuroendocrine tumors (NETs). In comparison to 111In-octreotide, 99mTc-Hynic-TOC has a higher imaging quality and leads to a lower radiation absorption in patients. 99mTc-Hynic-TOC was used for assessing primary diagnosis (n = 14) and during follow-up (n = 17) in patients with NETs. The scintigraphic findings were compared with computed tomography scans and follow-up. In 31 patients, 34 somatostatin receptor scans using 99mTc-Hynic-TOC were performed. The primary diagnoses were midgut NET. The scintigraphy was true positive in 17 patients, true negative in 9, false negative in 4, and false positive in 1. From these data, a sensitivity of 81%, specificity of 90%, positive predictive value of 94%, and negative predictive value of 69% were calculated. In summary, 99mTc-TOC represents a useful radiotracer in imaging SSTR-expressing tumor lesions with slightly higher sensitivity, higher imaging quality, and lower radiation exposure for patients compared to 111In-octreotide. A 1-day double-acquisition protocol should be used to reduce false-positive findings of the gut. |
| format | Article |
| id | doaj-art-789604bb5c9c46859f5069ad28afcede |
| institution | OA Journals |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2018-07-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-789604bb5c9c46859f5069ad28afcede2025-08-20T01:57:48ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122018-07-01170315115610.4103/wjnm.WJNM_41_1799mTc-Hynic-TOC imaging in the diagnostic of neuroendocrine tumorsKnut Liepe0Andreas Becker1Department of Nuclear Medicine, Klinikum Frankfurt (Oder), 15236 Frankfurt (Oder), GermanyDepartment of Internal Medicine Gastroenterology, Klinikum Frankfurt (Oder), 15236 Frankfurt (Oder), GermanyThe aim of this study was to assess the potential of 99mTc-Hynic-TOC imaging in the primary diagnosis and follow-up of midgut neuroendocrine tumors (NETs). In comparison to 111In-octreotide, 99mTc-Hynic-TOC has a higher imaging quality and leads to a lower radiation absorption in patients. 99mTc-Hynic-TOC was used for assessing primary diagnosis (n = 14) and during follow-up (n = 17) in patients with NETs. The scintigraphic findings were compared with computed tomography scans and follow-up. In 31 patients, 34 somatostatin receptor scans using 99mTc-Hynic-TOC were performed. The primary diagnoses were midgut NET. The scintigraphy was true positive in 17 patients, true negative in 9, false negative in 4, and false positive in 1. From these data, a sensitivity of 81%, specificity of 90%, positive predictive value of 94%, and negative predictive value of 69% were calculated. In summary, 99mTc-TOC represents a useful radiotracer in imaging SSTR-expressing tumor lesions with slightly higher sensitivity, higher imaging quality, and lower radiation exposure for patients compared to 111In-octreotide. A 1-day double-acquisition protocol should be used to reduce false-positive findings of the gut.http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_41_17 99mtc-hynic-toc imagingneuroendocrine tumoroctreotidesomatostatin receptor |
| spellingShingle | Knut Liepe Andreas Becker 99mTc-Hynic-TOC imaging in the diagnostic of neuroendocrine tumors World Journal of Nuclear Medicine 99mtc-hynic-toc imaging neuroendocrine tumor octreotide somatostatin receptor |
| title | 99mTc-Hynic-TOC imaging in the diagnostic of neuroendocrine tumors |
| title_full | 99mTc-Hynic-TOC imaging in the diagnostic of neuroendocrine tumors |
| title_fullStr | 99mTc-Hynic-TOC imaging in the diagnostic of neuroendocrine tumors |
| title_full_unstemmed | 99mTc-Hynic-TOC imaging in the diagnostic of neuroendocrine tumors |
| title_short | 99mTc-Hynic-TOC imaging in the diagnostic of neuroendocrine tumors |
| title_sort | 99mtc hynic toc imaging in the diagnostic of neuroendocrine tumors |
| topic | 99mtc-hynic-toc imaging neuroendocrine tumor octreotide somatostatin receptor |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_41_17 |
| work_keys_str_mv | AT knutliepe 99mtchynictocimaginginthediagnosticofneuroendocrinetumors AT andreasbecker 99mtchynictocimaginginthediagnosticofneuroendocrinetumors |