Efficacy and Safety of Recombinant Human Prourokinase in Acute Ischemic Stroke Within 4.5 h: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

ABSTRACT Background Acute ischemic stroke (AIS) requires timely thrombolysis to restore perfusion and minimize neurological damage. Recombinant human prourokinase (rhPro‐UK) has emerged as a promising alternative to alteplase, with potential efficacy and safety benefits within the critical 4.5‐h tre...

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Main Authors:	Muhammad Hassan Waseem, Zain Ul Abideen, Aiman Waheed, Hafsa Arshad Azam Raja, Sanan Rasheed, Muhammad Mukhlis, Muhammad Abdullah Ali, Marium Khan, Umama Alam, Muhammad Fawad Tahir, Javed Iqbal, Ubaid Farooq, Sania Aimen
Format:	Article
Language:	English
Published:	Wiley 2025-03-01
Series:	Brain and Behavior
Subjects:	alteplase \| ischemic stroke \| meta‐analysis \| recombinant human prourokinase \| systematic review
Online Access:	https://doi.org/10.1002/brb3.70420
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Efficacy and Safety of Recombinant Human Prourokinase in Acute Ischemic Stroke Within 4.5 h: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

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