Filgrastim Efficiency in Cats Naturally Infected with Feline Panleukopenia Virus
Feline Panleukopenia (FPL) infection is caused by feline panleukopenia virus (FPV), and it is considered one of the most severe cat’s infectious diseases. Since there is no specific antiviral treatment for FPL, the therapeutic protocol usually is focused on fluid therapy and supportive care. However...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Animals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2615/14/24/3582 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850049703289290752 |
|---|---|
| author | Mihaela Anca Dascalu Florentina Daraban Bocaneti Octavian Soreanu Paul Tutu Andreea Cozma Serban Morosan Oana Tanase |
| author_facet | Mihaela Anca Dascalu Florentina Daraban Bocaneti Octavian Soreanu Paul Tutu Andreea Cozma Serban Morosan Oana Tanase |
| author_sort | Mihaela Anca Dascalu |
| collection | DOAJ |
| description | Feline Panleukopenia (FPL) infection is caused by feline panleukopenia virus (FPV), and it is considered one of the most severe cat’s infectious diseases. Since there is no specific antiviral treatment for FPL, the therapeutic protocol usually is focused on fluid therapy and supportive care. However, filgrastim, a granulocyte colony-stimulating factor (G-CSF) used in human medicine to treat neutropenia and leukopenia, has been lately used in treating FPV disease, providing promising results. During January 2022 and September 2024, twenty-two cats diagnosed with feline panleukopenia virus were subjected to filgrastim (Zarzio<sup>®</sup>, Sandoz, Kundl, Austria) administration at a dose of 6 µg/kg for 3 consecutive days. The 4th day was a break day, and in the 5th day, the complete blood count was repeated. White blood cells, lymphocytes, monocytes, neutrophils and eosinophils parameters improved after Zarzio<sup>®</sup> administration, with a significant statistical difference (<i>p</i> < 0.01) when their values between day 1 (pre Zarzio<sup>®</sup> administration) and day 5 (post Zarzio<sup>®</sup> administration) were analysed. However, red blood cells, haemoglobin, haematocrit and platelets parameters registered a considerable reduction from day 1 to day 5 with a significant statistical difference (<i>p</i> < 0.01), considered as post-administration side effects. In our study, the survival rate following Zarzio<sup>®</sup> administration was 100%, suggesting that the protocol involving three doses is effective in restoring the leukopenia and neutropenia. |
| format | Article |
| id | doaj-art-789128a3153147e88f2467d07c2bf39a |
| institution | DOAJ |
| issn | 2076-2615 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj-art-789128a3153147e88f2467d07c2bf39a2025-08-20T02:53:40ZengMDPI AGAnimals2076-26152024-12-011424358210.3390/ani14243582Filgrastim Efficiency in Cats Naturally Infected with Feline Panleukopenia VirusMihaela Anca Dascalu0Florentina Daraban Bocaneti1Octavian Soreanu2Paul Tutu3Andreea Cozma4Serban Morosan5Oana Tanase6Department of Public Health, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” Iasi University of Life Sciences, Mihail Sadoveanu Alley, No. 8, 700489 Iasi, RomaniaDepartment of Public Health, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” Iasi University of Life Sciences, Mihail Sadoveanu Alley, No. 8, 700489 Iasi, RomaniaDepartment of Public Health, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” Iasi University of Life Sciences, Mihail Sadoveanu Alley, No. 8, 700489 Iasi, RomaniaDepartment of Public Health, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” Iasi University of Life Sciences, Mihail Sadoveanu Alley, No. 8, 700489 Iasi, RomaniaDepartment of Exact Sciences, Faculty of Horticulture, “Ion Ionescu de la Brad” Iasi University of Life Sciences, Mihail Sadoveanu Alley, No. 3, 700490 Iasi, RomaniaDepartment of Public Health, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” Iasi University of Life Sciences, Mihail Sadoveanu Alley, No. 8, 700489 Iasi, RomaniaDepartment of Public Health, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” Iasi University of Life Sciences, Mihail Sadoveanu Alley, No. 8, 700489 Iasi, RomaniaFeline Panleukopenia (FPL) infection is caused by feline panleukopenia virus (FPV), and it is considered one of the most severe cat’s infectious diseases. Since there is no specific antiviral treatment for FPL, the therapeutic protocol usually is focused on fluid therapy and supportive care. However, filgrastim, a granulocyte colony-stimulating factor (G-CSF) used in human medicine to treat neutropenia and leukopenia, has been lately used in treating FPV disease, providing promising results. During January 2022 and September 2024, twenty-two cats diagnosed with feline panleukopenia virus were subjected to filgrastim (Zarzio<sup>®</sup>, Sandoz, Kundl, Austria) administration at a dose of 6 µg/kg for 3 consecutive days. The 4th day was a break day, and in the 5th day, the complete blood count was repeated. White blood cells, lymphocytes, monocytes, neutrophils and eosinophils parameters improved after Zarzio<sup>®</sup> administration, with a significant statistical difference (<i>p</i> < 0.01) when their values between day 1 (pre Zarzio<sup>®</sup> administration) and day 5 (post Zarzio<sup>®</sup> administration) were analysed. However, red blood cells, haemoglobin, haematocrit and platelets parameters registered a considerable reduction from day 1 to day 5 with a significant statistical difference (<i>p</i> < 0.01), considered as post-administration side effects. In our study, the survival rate following Zarzio<sup>®</sup> administration was 100%, suggesting that the protocol involving three doses is effective in restoring the leukopenia and neutropenia.https://www.mdpi.com/2076-2615/14/24/3582felinefilgrastimhG-CSFFeline panleukopenia virusZarzio |
| spellingShingle | Mihaela Anca Dascalu Florentina Daraban Bocaneti Octavian Soreanu Paul Tutu Andreea Cozma Serban Morosan Oana Tanase Filgrastim Efficiency in Cats Naturally Infected with Feline Panleukopenia Virus Animals feline filgrastim hG-CSF Feline panleukopenia virus Zarzio |
| title | Filgrastim Efficiency in Cats Naturally Infected with Feline Panleukopenia Virus |
| title_full | Filgrastim Efficiency in Cats Naturally Infected with Feline Panleukopenia Virus |
| title_fullStr | Filgrastim Efficiency in Cats Naturally Infected with Feline Panleukopenia Virus |
| title_full_unstemmed | Filgrastim Efficiency in Cats Naturally Infected with Feline Panleukopenia Virus |
| title_short | Filgrastim Efficiency in Cats Naturally Infected with Feline Panleukopenia Virus |
| title_sort | filgrastim efficiency in cats naturally infected with feline panleukopenia virus |
| topic | feline filgrastim hG-CSF Feline panleukopenia virus Zarzio |
| url | https://www.mdpi.com/2076-2615/14/24/3582 |
| work_keys_str_mv | AT mihaelaancadascalu filgrastimefficiencyincatsnaturallyinfectedwithfelinepanleukopeniavirus AT florentinadarabanbocaneti filgrastimefficiencyincatsnaturallyinfectedwithfelinepanleukopeniavirus AT octaviansoreanu filgrastimefficiencyincatsnaturallyinfectedwithfelinepanleukopeniavirus AT paultutu filgrastimefficiencyincatsnaturallyinfectedwithfelinepanleukopeniavirus AT andreeacozma filgrastimefficiencyincatsnaturallyinfectedwithfelinepanleukopeniavirus AT serbanmorosan filgrastimefficiencyincatsnaturallyinfectedwithfelinepanleukopeniavirus AT oanatanase filgrastimefficiencyincatsnaturallyinfectedwithfelinepanleukopeniavirus |