Good vision without peripheries: behavioral and fMRI evidence
Abstract In healthy vision, bright slow-motion stimuli are processed primarily by the regions of the visual system that receive input from the central part of the scene, whereas processing of dark fast-motion stimuli is more dependent on peripheral visual input. We tested 31 retinitis pigmentosa (RP...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-76879-9 |
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| author | M. Ninghetto A. Kozak T. Gałecki K. Szulborski J. P. Szaflik M. Ołdak A. Marchewka K. Burnat |
| author_facet | M. Ninghetto A. Kozak T. Gałecki K. Szulborski J. P. Szaflik M. Ołdak A. Marchewka K. Burnat |
| author_sort | M. Ninghetto |
| collection | DOAJ |
| description | Abstract In healthy vision, bright slow-motion stimuli are processed primarily by the regions of the visual system that receive input from the central part of the scene, whereas processing of dark fast-motion stimuli is more dependent on peripheral visual input. We tested 31 retinitis pigmentosa (RP) patients with long-term loss of peripheral photoreceptors and healthy controls with temporarily limited peripheral vision. We measured motion-based acuity using random-dot kinematograms, establishing individual thresholds for differentiating a circle from an ellipse. Participants subsequently performed a functional magnetic resonance imaging (fMRI) task set at a constant level of difficulty. The results showed that limiting vision did not affect motion-acuity thresholds in control participants but did cause different brain activations than those in RP patients, indicating prompt implementation of the strategy that would be perceptually successful. Compared with controls with both full and limited vision, impaired motion acuity in RP patients led to decreased brain activation, particularly in the primary peripheral visual areas V1-3. Importantly, compared with controls in full vision, matched decreased activation in MT+/V5, salience-processing cortices and the superior temporal cortex were detected in RP patients and in controls with limited peripheral vision, revealing brain networks that compensate for the loss of peripheral vision. |
| format | Article |
| id | doaj-art-788f2b33ff5849acb233fcdfd25545a8 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-788f2b33ff5849acb233fcdfd25545a82025-08-20T03:22:12ZengNature PortfolioScientific Reports2045-23222024-11-0114111710.1038/s41598-024-76879-9Good vision without peripheries: behavioral and fMRI evidenceM. Ninghetto0A. Kozak1T. Gałecki2K. Szulborski3J. P. Szaflik4M. Ołdak5A. Marchewka6K. Burnat7Laboratory of Brain Imaging, Neurobiology Center, Nencki Institute of Experimental BiologyLaboratory of Brain Imaging, Neurobiology Center, Nencki Institute of Experimental BiologyDepartment of Ophthalmology, Medical University of WarsawDepartment of Ophthalmology, Medical University of WarsawDepartment of Ophthalmology, Medical University of WarsawDepartment of Histology and Embryology, Medical University of WarsawLaboratory of Brain Imaging, Neurobiology Center, Nencki Institute of Experimental BiologyLaboratory of Brain Imaging, Neurobiology Center, Nencki Institute of Experimental BiologyAbstract In healthy vision, bright slow-motion stimuli are processed primarily by the regions of the visual system that receive input from the central part of the scene, whereas processing of dark fast-motion stimuli is more dependent on peripheral visual input. We tested 31 retinitis pigmentosa (RP) patients with long-term loss of peripheral photoreceptors and healthy controls with temporarily limited peripheral vision. We measured motion-based acuity using random-dot kinematograms, establishing individual thresholds for differentiating a circle from an ellipse. Participants subsequently performed a functional magnetic resonance imaging (fMRI) task set at a constant level of difficulty. The results showed that limiting vision did not affect motion-acuity thresholds in control participants but did cause different brain activations than those in RP patients, indicating prompt implementation of the strategy that would be perceptually successful. Compared with controls with both full and limited vision, impaired motion acuity in RP patients led to decreased brain activation, particularly in the primary peripheral visual areas V1-3. Importantly, compared with controls in full vision, matched decreased activation in MT+/V5, salience-processing cortices and the superior temporal cortex were detected in RP patients and in controls with limited peripheral vision, revealing brain networks that compensate for the loss of peripheral vision.https://doi.org/10.1038/s41598-024-76879-9 |
| spellingShingle | M. Ninghetto A. Kozak T. Gałecki K. Szulborski J. P. Szaflik M. Ołdak A. Marchewka K. Burnat Good vision without peripheries: behavioral and fMRI evidence Scientific Reports |
| title | Good vision without peripheries: behavioral and fMRI evidence |
| title_full | Good vision without peripheries: behavioral and fMRI evidence |
| title_fullStr | Good vision without peripheries: behavioral and fMRI evidence |
| title_full_unstemmed | Good vision without peripheries: behavioral and fMRI evidence |
| title_short | Good vision without peripheries: behavioral and fMRI evidence |
| title_sort | good vision without peripheries behavioral and fmri evidence |
| url | https://doi.org/10.1038/s41598-024-76879-9 |
| work_keys_str_mv | AT mninghetto goodvisionwithoutperipheriesbehavioralandfmrievidence AT akozak goodvisionwithoutperipheriesbehavioralandfmrievidence AT tgałecki goodvisionwithoutperipheriesbehavioralandfmrievidence AT kszulborski goodvisionwithoutperipheriesbehavioralandfmrievidence AT jpszaflik goodvisionwithoutperipheriesbehavioralandfmrievidence AT mołdak goodvisionwithoutperipheriesbehavioralandfmrievidence AT amarchewka goodvisionwithoutperipheriesbehavioralandfmrievidence AT kburnat goodvisionwithoutperipheriesbehavioralandfmrievidence |