Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile
Reactivity of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3- carbonitrile towards thioglycolic acid resulted in thiazole derivative 1. The latter reacted with different chemical reagents to give thiazole, pyrano[2,3-d]thiazole and thiazolo[ 4,5-d]thiazole derivatives. Cytotoxicity effects of the new...
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| Format: | Article |
| Language: | English |
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Sciendo
2017-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2017-0040 |
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| author | Mohareb Rafat M. Abdallah Amira E. M. Ahmed Ebtsam A. |
| author_facet | Mohareb Rafat M. Abdallah Amira E. M. Ahmed Ebtsam A. |
| author_sort | Mohareb Rafat M. |
| collection | DOAJ |
| description | Reactivity of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3- carbonitrile towards thioglycolic acid resulted in thiazole derivative 1. The latter reacted with different chemical reagents to give thiazole, pyrano[2,3-d]thiazole and thiazolo[ 4,5-d]thiazole derivatives. Cytotoxicity effects of the newly synthesized products against six cancer cell lines, namely, human gastric cancer (NUGC), human colon cancer (DLD- 1), human liver cancer (HA22T and HEPG-2), human breast cancer (MCF) and nasopharyngeal carcinoma (HONE-1) as well as against a normal fibroblast cell (WI-38) were evaluated. The study showed that the 4,5,6,7 tetrahydrobenzo[ b] thiophene derivatives 6a, 7, 8a,b, 9b and 10b,c w ere t he most active compounds. Their potencies were attributed to the presence of the electron withdrawing groups. |
| format | Article |
| id | doaj-art-788ed1d4fc3e4b80aae38ccbaab4432d |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2017-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-788ed1d4fc3e4b80aae38ccbaab4432d2025-02-02T11:49:55ZengSciendoActa Pharmaceutica1846-95582017-12-0167449551010.1515/acph-2017-0040acph-2017-0040Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrileMohareb Rafat M.0Abdallah Amira E. M.1Ahmed Ebtsam A.2Department of Chemistry Faculty of Science Cairo University, Giza, A. R. EgyptDepartment of Chemistry Faculty of Science, Helwan University Ain Helwan, Cairo A. R. EgyptDepartment of Chemistry Faculty of Science, Helwan University Ain Helwan, Cairo A. R. EgyptReactivity of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3- carbonitrile towards thioglycolic acid resulted in thiazole derivative 1. The latter reacted with different chemical reagents to give thiazole, pyrano[2,3-d]thiazole and thiazolo[ 4,5-d]thiazole derivatives. Cytotoxicity effects of the newly synthesized products against six cancer cell lines, namely, human gastric cancer (NUGC), human colon cancer (DLD- 1), human liver cancer (HA22T and HEPG-2), human breast cancer (MCF) and nasopharyngeal carcinoma (HONE-1) as well as against a normal fibroblast cell (WI-38) were evaluated. The study showed that the 4,5,6,7 tetrahydrobenzo[ b] thiophene derivatives 6a, 7, 8a,b, 9b and 10b,c w ere t he most active compounds. Their potencies were attributed to the presence of the electron withdrawing groups.https://doi.org/10.1515/acph-2017-0040tetrahydrobenzo[b]thiophenethiazolepyrano[ 2,3-d]thiazolethiazolo[4,5-d]thiazolecytotoxicityanticancer activity |
| spellingShingle | Mohareb Rafat M. Abdallah Amira E. M. Ahmed Ebtsam A. Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile Acta Pharmaceutica tetrahydrobenzo[b]thiophene thiazole pyrano[ 2,3-d]thiazole thiazolo[4,5-d]thiazole cytotoxicity anticancer activity |
| title | Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile |
| title_full | Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile |
| title_fullStr | Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile |
| title_full_unstemmed | Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile |
| title_short | Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile |
| title_sort | synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2 amino 4 5 6 7 tetrahydrobenzo b thiophene 3 carbonitrile |
| topic | tetrahydrobenzo[b]thiophene thiazole pyrano[ 2,3-d]thiazole thiazolo[4,5-d]thiazole cytotoxicity anticancer activity |
| url | https://doi.org/10.1515/acph-2017-0040 |
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