ProC6C, a novel multi-stage malaria vaccine, elicits functional antibodies against the minor and central repeats of the Circumsporozoite Protein in human adults

ProC6C, a novel multi-stage malaria vaccine, elicits functional antibodies against the minor and central repeats of the Circumsporozoite Protein in human adults

IntroductionProC6C is a multi-stage malaria vaccine which includes Plasmodium falciparum Circumsporozoite Protein (PfCSP), Pfs48/45 and Pfs230 sequences, designed to elicit functional antibodies that prevent sporozoite invasion of human hepatocytes (PfCSP) and parasite development in mosquitoes (Pfs...

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Bibliographic Details
Main Authors: Jordan Plieskatt, Ebenezer Addo Ofori, Mohammad Naghizadeh, Kazutoyo Miura, Yevel Flores-Garcia, Nis Borbye-Lorenzen, Alfred B. Tiono, Kristin Skogstrand, Issaka Sagara, Fidel Zavala, Michael Theisen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
Malaria
Circumsporozoite protein
CSP
vaccine
antibodies
clinical trial
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1481829/full
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