Calculation of Involved and Noninvolved Organs Doses in Carbon Therapy of Brain Tumor Using GEANT4 Simulation Toolkit
Introduction: This study used the GEANT4 Monte Carlo toolkit for radiation transport simulations in brain carbon therapy, incorporating a human phantom model to accurately assess dose delivery to targeted and non-targeted organs. Weight factors were employed to generate a Spread Out Bragg Peak (SOBP...
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Mashhad University of Medical Sciences
2024-10-01
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| Series: | Iranian Journal of Medical Physics |
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| Online Access: | https://ijmp.mums.ac.ir/article_25461_9ede827a90aee31a652da0f2845afe43.pdf |
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| author | Maria Ahmadi Seyed Mohammad Motevalli Payvand Taherparvar Vahid zanganeh |
| author_facet | Maria Ahmadi Seyed Mohammad Motevalli Payvand Taherparvar Vahid zanganeh |
| author_sort | Maria Ahmadi |
| collection | DOAJ |
| description | Introduction: This study used the GEANT4 Monte Carlo toolkit for radiation transport simulations in brain carbon therapy, incorporating a human phantom model to accurately assess dose delivery to targeted and non-targeted organs. Weight factors were employed to generate a Spread Out Bragg Peak (SOBP).Material and Methods: The study used the ORNL-MIRD phantom to simulate carbon therapy for brain tumors, finding that the optimal energy range for carbon ions was 2420-2560 MeV to effectively cover the tumor. To achieve a homogeneous radiation dose, a Spread Out ragg Peak (SOBP) was generated using multiple Bragg peaks with specific intensity factors. Beam parameters were also evaluated per ICRU guidelines.Results: This study estimated the flux and dose distributions of secondary particles—protons, electrons, neutrons, alpha particles, and photons—in the brain tumor and surrounding tissues. We calculated the cumulative dose from both carbon ions and secondary particles, finding an absorbed dose ratio of 0.003 in healthy brain tissue compared to the tumor, with values of 4.8 × 10-4 for the skull and 2.6 × 10-5 for the thyroid. Notably, neutrons and photons can significantly increase energy transfer to distant organs, raising secondary cancer risk.Conclusion: The findings presented in this article demonstrated that the involvement of secondary particles in the dose received by both the brain and other organs remains minimal, as the highest absorbed dose was predominantly localized within the tumor. |
| format | Article |
| id | doaj-art-788723bd4e184942ad937972b3405942 |
| institution | Kabale University |
| issn | 2345-3672 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Physics |
| spelling | doaj-art-788723bd4e184942ad937972b34059422025-01-18T07:29:18ZengMashhad University of Medical SciencesIranian Journal of Medical Physics2345-36722024-10-0121528729410.22038/ijmp.2023.71006.225125461Calculation of Involved and Noninvolved Organs Doses in Carbon Therapy of Brain Tumor Using GEANT4 Simulation ToolkitMaria Ahmadi0Seyed Mohammad Motevalli1Payvand Taherparvar2Vahid zanganeh3Department of Nuclear Physics, Faculty of Science, University of Mazandaran P.O.Box 47415-416, Babolsar, IranDepartment of Nuclear Physics, Faculty of Science, University of Mazandaran, P. O. Box 47415-416, Babolsar, IranDepartment of Physics, Faculty of Science, University of Guilan, Rasht, IranGolestan university faculty of science, department of physics, Golestan, IranIntroduction: This study used the GEANT4 Monte Carlo toolkit for radiation transport simulations in brain carbon therapy, incorporating a human phantom model to accurately assess dose delivery to targeted and non-targeted organs. Weight factors were employed to generate a Spread Out Bragg Peak (SOBP).Material and Methods: The study used the ORNL-MIRD phantom to simulate carbon therapy for brain tumors, finding that the optimal energy range for carbon ions was 2420-2560 MeV to effectively cover the tumor. To achieve a homogeneous radiation dose, a Spread Out ragg Peak (SOBP) was generated using multiple Bragg peaks with specific intensity factors. Beam parameters were also evaluated per ICRU guidelines.Results: This study estimated the flux and dose distributions of secondary particles—protons, electrons, neutrons, alpha particles, and photons—in the brain tumor and surrounding tissues. We calculated the cumulative dose from both carbon ions and secondary particles, finding an absorbed dose ratio of 0.003 in healthy brain tissue compared to the tumor, with values of 4.8 × 10-4 for the skull and 2.6 × 10-5 for the thyroid. Notably, neutrons and photons can significantly increase energy transfer to distant organs, raising secondary cancer risk.Conclusion: The findings presented in this article demonstrated that the involvement of secondary particles in the dose received by both the brain and other organs remains minimal, as the highest absorbed dose was predominantly localized within the tumor.https://ijmp.mums.ac.ir/article_25461_9ede827a90aee31a652da0f2845afe43.pdfheavy ion radiotherapybrainmonte carlo simulation sobp |
| spellingShingle | Maria Ahmadi Seyed Mohammad Motevalli Payvand Taherparvar Vahid zanganeh Calculation of Involved and Noninvolved Organs Doses in Carbon Therapy of Brain Tumor Using GEANT4 Simulation Toolkit Iranian Journal of Medical Physics heavy ion radiotherapy brain monte carlo simulation sobp |
| title | Calculation of Involved and Noninvolved Organs Doses in Carbon Therapy of Brain Tumor Using GEANT4 Simulation Toolkit |
| title_full | Calculation of Involved and Noninvolved Organs Doses in Carbon Therapy of Brain Tumor Using GEANT4 Simulation Toolkit |
| title_fullStr | Calculation of Involved and Noninvolved Organs Doses in Carbon Therapy of Brain Tumor Using GEANT4 Simulation Toolkit |
| title_full_unstemmed | Calculation of Involved and Noninvolved Organs Doses in Carbon Therapy of Brain Tumor Using GEANT4 Simulation Toolkit |
| title_short | Calculation of Involved and Noninvolved Organs Doses in Carbon Therapy of Brain Tumor Using GEANT4 Simulation Toolkit |
| title_sort | calculation of involved and noninvolved organs doses in carbon therapy of brain tumor using geant4 simulation toolkit |
| topic | heavy ion radiotherapy brain monte carlo simulation sobp |
| url | https://ijmp.mums.ac.ir/article_25461_9ede827a90aee31a652da0f2845afe43.pdf |
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