Zebrafish as a model system for studying reproductive diseases
Reproductive system diseases have become a major health challenge facing humans, so extensive investigations are needed to understand their complex pathogenesis and summarize effective treatments. In the study of reproductive diseases, mice are the most commonly used animal model. However, the cost...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1481634/full |
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| author | Wenwen Zha Weitao Hu Chenkai Ge Jianjun Chen Jianjun Chen Zigang Cao |
| author_facet | Wenwen Zha Weitao Hu Chenkai Ge Jianjun Chen Jianjun Chen Zigang Cao |
| author_sort | Wenwen Zha |
| collection | DOAJ |
| description | Reproductive system diseases have become a major health challenge facing humans, so extensive investigations are needed to understand their complex pathogenesis and summarize effective treatments. In the study of reproductive diseases, mice are the most commonly used animal model. However, the cost and time required to establish mouse animal models are high. The existing zebrafish model can solve this problem well. Zebrafish is an animal model with great application prospects and has lots of advantages, including high degree of genetic conservation with humans, short reproductive cycle, transparent embryos, and rapid growth, providing unique opportunities for high-throughput drug screening and identification of potential treatments. Researchers have successfully used chemical induction, physical damage, gene editing technology, etc., to induce reproductive system damage in zebrafish to study the biological processes related to its reproductive diseases. Therefore, in this review, the main models and related advantages of zebrafish in reproductive diseases are summarized, the pathological mechanisms of zebrafish as a reproductive disease model are clarified, and new perspectives and valuable insights are provided for the treatment of human reproductive diseases. The literature and data cited in the review are all from PubMed, covering important research results on zebrafish reproductive diseases in the past 10 years. |
| format | Article |
| id | doaj-art-78819aa866404f1a9bef12cff31f5e9e |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-78819aa866404f1a9bef12cff31f5e9e2025-08-20T02:40:24ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-12-011210.3389/fcell.2024.14816341481634Zebrafish as a model system for studying reproductive diseasesWenwen Zha0Weitao Hu1Chenkai Ge2Jianjun Chen3Jianjun Chen4Zigang Cao5Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, College of Chinese Medicine, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Jinggangshan University, Ji’an, ChinaJiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Organs Development and Epigenetics, Key Laboratory of Jiangxi Province for Biological Invasion and Biosecurity, College of Life Sciences, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Jinggangshan University, Ji’an, ChinaJiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Organs Development and Epigenetics, Key Laboratory of Jiangxi Province for Biological Invasion and Biosecurity, College of Life Sciences, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Jinggangshan University, Ji’an, ChinaShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Department of Pediatrics, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Big Data in Health Science School of Public Health, Institute of Medical Genetics, Tongji University School of Medicine, Tongji University, Shanghai, ChinaJiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Organs Development and Epigenetics, Key Laboratory of Jiangxi Province for Biological Invasion and Biosecurity, College of Life Sciences, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Jinggangshan University, Ji’an, ChinaReproductive system diseases have become a major health challenge facing humans, so extensive investigations are needed to understand their complex pathogenesis and summarize effective treatments. In the study of reproductive diseases, mice are the most commonly used animal model. However, the cost and time required to establish mouse animal models are high. The existing zebrafish model can solve this problem well. Zebrafish is an animal model with great application prospects and has lots of advantages, including high degree of genetic conservation with humans, short reproductive cycle, transparent embryos, and rapid growth, providing unique opportunities for high-throughput drug screening and identification of potential treatments. Researchers have successfully used chemical induction, physical damage, gene editing technology, etc., to induce reproductive system damage in zebrafish to study the biological processes related to its reproductive diseases. Therefore, in this review, the main models and related advantages of zebrafish in reproductive diseases are summarized, the pathological mechanisms of zebrafish as a reproductive disease model are clarified, and new perspectives and valuable insights are provided for the treatment of human reproductive diseases. The literature and data cited in the review are all from PubMed, covering important research results on zebrafish reproductive diseases in the past 10 years.https://www.frontiersin.org/articles/10.3389/fcell.2024.1481634/fullreproductive diseaseszebrafishgerm cellsCRISPRanimal models |
| spellingShingle | Wenwen Zha Weitao Hu Chenkai Ge Jianjun Chen Jianjun Chen Zigang Cao Zebrafish as a model system for studying reproductive diseases Frontiers in Cell and Developmental Biology reproductive diseases zebrafish germ cells CRISPR animal models |
| title | Zebrafish as a model system for studying reproductive diseases |
| title_full | Zebrafish as a model system for studying reproductive diseases |
| title_fullStr | Zebrafish as a model system for studying reproductive diseases |
| title_full_unstemmed | Zebrafish as a model system for studying reproductive diseases |
| title_short | Zebrafish as a model system for studying reproductive diseases |
| title_sort | zebrafish as a model system for studying reproductive diseases |
| topic | reproductive diseases zebrafish germ cells CRISPR animal models |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1481634/full |
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