Behavioral signature of trihexyphenidyl in the TOR1A (DYT1) knockin mouse model of dystonia

Dystonia is a neurological disorder characterized by involuntary repetitive movements and abnormal postures. Animal models have played a pivotal role in studying the pathophysiology of dystonia. However, many genetic models, e.g., the Tor1a+/ΔE (DYT1) mouse, lack an overt motor phenotype, despite si...

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Bibliographic Details
Main Authors: Ahmad Abdal Qader, Yuping Donsante, Jeffrey E. Markowitz, H. A. Jinnah, Chethan Pandarinath, Ellen J. Hess
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Dystonia
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Online Access:https://www.frontierspartnerships.org/articles/10.3389/dyst.2025.15034/full
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