Associations between night-time sleep duration and fasting glucose and ratio of triglyceride to high-density lipoprotein cholesterol among adults free of type 2 diabetes or without diagnosed type 2 diabetes: a multicentre, cross-sectional study in China
Objectives We aimed to assess the associations between night-time sleep duration and fasting glucose (FG), triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio and body mass index (BMI) among adults free of type 2 diabetes (T2D) or without diagnosed T2D.Design Cross-sectional stud...
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BMJ Publishing Group
2022-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/7/e062239.full |
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| author | Rong Zhang Li Zhang Qiang Li Minying Zhang Feng Liu Shuo Chen Yu-Jie Niu Xin Qi Chunjun Li Jiangshan He Chenglin Hong Yuxue Wang Yaqi Fan Pei Guo Binbin Zhang Shitao Ma Mianzhi Zhang |
| author_facet | Rong Zhang Li Zhang Qiang Li Minying Zhang Feng Liu Shuo Chen Yu-Jie Niu Xin Qi Chunjun Li Jiangshan He Chenglin Hong Yuxue Wang Yaqi Fan Pei Guo Binbin Zhang Shitao Ma Mianzhi Zhang |
| author_sort | Rong Zhang |
| collection | DOAJ |
| description | Objectives We aimed to assess the associations between night-time sleep duration and fasting glucose (FG), triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio and body mass index (BMI) among adults free of type 2 diabetes (T2D) or without diagnosed T2D.Design Cross-sectional study.Setting Medical examination centres at six hospitals in Beijing-Tianjin-Hebei region, China.Participants Participants were recruited via multistage, stratified cluster sampling. We included adults free of T2D or without diagnosed T2D who attended for physical examination and completed the validated questionnaire. 32 497 participants were included in the study, of whom 52.50% were men.Primary and secondary outcome measures FG, TG, HDL-C, height and weight were measured.Results Overall, 12.80% and 9.67% reported night sleep duration <7 hours and ≥9 hours, respectively; 6.91% had elevated FG and 3.57% had undiagnosed T2D. Sleep duration had an independent, U-shaped associated with FG (β1 (linear term)=−0.111, p=0.047; β2 (quadratic term)=0.008, p=0.026) with 6.9 hours of sleep associated with the lowest FG and a negative association with BMI (β=−0.154, p<0.001). BMI mediated a U-shaped association of sleep duration with TG/HDL-C (β1=−0.040, p=0.017; β2=0.003, p=0.023).Conclusions Both short and long night-time sleep was associated with elevated FG, and short sleep duration was associated with increased BMI. BMI mediated a U-shaped association between sleep duration and TG/HDL-C. |
| format | Article |
| id | doaj-art-786ba3c2c460449cad43963f7a541a33 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-786ba3c2c460449cad43963f7a541a332025-01-30T19:20:09ZengBMJ Publishing GroupBMJ Open2044-60552022-07-0112710.1136/bmjopen-2022-062239Associations between night-time sleep duration and fasting glucose and ratio of triglyceride to high-density lipoprotein cholesterol among adults free of type 2 diabetes or without diagnosed type 2 diabetes: a multicentre, cross-sectional study in ChinaRong Zhang0Li Zhang1Qiang Li2Minying Zhang3Feng Liu4Shuo Chen5Yu-Jie Niu6Xin Qi7Chunjun Li8Jiangshan He9Chenglin Hong10Yuxue Wang11Yaqi Fan12Pei Guo13Binbin Zhang14Shitao Ma15Mianzhi Zhang16Department of Neonatology, Children`s Hospital of Fudan University, Shanghai, ChinaWXi Biologics, Shanghai, ChinaDepartment of Thoracic Surgery, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China1The University of Texas MD Anderson Cancer Center, Houston, TX, USANational Clinical Research Center for Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, ChinaBeijing Physical Examination Center, Beijing, ChinaHebei Key Laboratory of Environment and Human Health, Shijiazhuang, Hebei, China4 School of Medicine, UCLA, Los Angeles, California, USATianjin People`s Hospital Tianjin Union Medical Center, Tianjin, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaDepartment of Social Welfare, University of California, Los Angeles, California, USASchool of Medicine, Nankai University, Tianjin, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaHebei Key Laboratory of Environment and Human Health, Shijiazhuang, Hebei, ChinaTianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, ChinaObjectives We aimed to assess the associations between night-time sleep duration and fasting glucose (FG), triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio and body mass index (BMI) among adults free of type 2 diabetes (T2D) or without diagnosed T2D.Design Cross-sectional study.Setting Medical examination centres at six hospitals in Beijing-Tianjin-Hebei region, China.Participants Participants were recruited via multistage, stratified cluster sampling. We included adults free of T2D or without diagnosed T2D who attended for physical examination and completed the validated questionnaire. 32 497 participants were included in the study, of whom 52.50% were men.Primary and secondary outcome measures FG, TG, HDL-C, height and weight were measured.Results Overall, 12.80% and 9.67% reported night sleep duration <7 hours and ≥9 hours, respectively; 6.91% had elevated FG and 3.57% had undiagnosed T2D. Sleep duration had an independent, U-shaped associated with FG (β1 (linear term)=−0.111, p=0.047; β2 (quadratic term)=0.008, p=0.026) with 6.9 hours of sleep associated with the lowest FG and a negative association with BMI (β=−0.154, p<0.001). BMI mediated a U-shaped association of sleep duration with TG/HDL-C (β1=−0.040, p=0.017; β2=0.003, p=0.023).Conclusions Both short and long night-time sleep was associated with elevated FG, and short sleep duration was associated with increased BMI. BMI mediated a U-shaped association between sleep duration and TG/HDL-C.https://bmjopen.bmj.com/content/12/7/e062239.full |
| spellingShingle | Rong Zhang Li Zhang Qiang Li Minying Zhang Feng Liu Shuo Chen Yu-Jie Niu Xin Qi Chunjun Li Jiangshan He Chenglin Hong Yuxue Wang Yaqi Fan Pei Guo Binbin Zhang Shitao Ma Mianzhi Zhang Associations between night-time sleep duration and fasting glucose and ratio of triglyceride to high-density lipoprotein cholesterol among adults free of type 2 diabetes or without diagnosed type 2 diabetes: a multicentre, cross-sectional study in China BMJ Open |
| title | Associations between night-time sleep duration and fasting glucose and ratio of triglyceride to high-density lipoprotein cholesterol among adults free of type 2 diabetes or without diagnosed type 2 diabetes: a multicentre, cross-sectional study in China |
| title_full | Associations between night-time sleep duration and fasting glucose and ratio of triglyceride to high-density lipoprotein cholesterol among adults free of type 2 diabetes or without diagnosed type 2 diabetes: a multicentre, cross-sectional study in China |
| title_fullStr | Associations between night-time sleep duration and fasting glucose and ratio of triglyceride to high-density lipoprotein cholesterol among adults free of type 2 diabetes or without diagnosed type 2 diabetes: a multicentre, cross-sectional study in China |
| title_full_unstemmed | Associations between night-time sleep duration and fasting glucose and ratio of triglyceride to high-density lipoprotein cholesterol among adults free of type 2 diabetes or without diagnosed type 2 diabetes: a multicentre, cross-sectional study in China |
| title_short | Associations between night-time sleep duration and fasting glucose and ratio of triglyceride to high-density lipoprotein cholesterol among adults free of type 2 diabetes or without diagnosed type 2 diabetes: a multicentre, cross-sectional study in China |
| title_sort | associations between night time sleep duration and fasting glucose and ratio of triglyceride to high density lipoprotein cholesterol among adults free of type 2 diabetes or without diagnosed type 2 diabetes a multicentre cross sectional study in china |
| url | https://bmjopen.bmj.com/content/12/7/e062239.full |
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