Prophylactic use of recombinant ADAMTS-13 during pregnancy for congenital thrombotic thrombocytopenic purpura

Prophylactic use of recombinant ADAMTS-13 during pregnancy for congenital thrombotic thrombocytopenic purpura

Background: Congenital thrombotic thrombocytopenic purpura (cTTP) related to ADAMTS-13 deficiency is associated with a maternal risk of death of 10% and a risk of fetal loss greater than 50% without treatment. Key Clinical Question: Is prophylactic use of recombinant (r)ADAMTS-13 during pregnancy in...

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Bibliographic Details
Main Authors: Éloïse Colliou, Agnès Ribes, Clotilde Gaible, Mathilde Marlas, David Ribes, Isabelle Labadens, Paul Guerby, Stanislas Faguer
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
ADAMTS-13
congenital and thrombotic thrombocytopenic purpura
pregnancy
prophylaxis
Online Access:http://www.sciencedirect.com/science/article/pii/S2475037925000111
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