Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed Supplements
Herbal products are being used and trusted globally for thousands of years for their health benefits and limited side effects. Globally, a general belief amongst the consumers is that herbal supplements are always safe because they are “natural.” But later, research reveals that they may not be safe...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2018/9412167 |
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| author | Boddapati Srinivasa Rao C. V. Chandrasekaran H. S. Srikanth Murugan Sasikumar R. Edwin Jothie Begum Haseena Bethapudi Bharathi Ramasamy Selvam D’Souza Prashanth |
| author_facet | Boddapati Srinivasa Rao C. V. Chandrasekaran H. S. Srikanth Murugan Sasikumar R. Edwin Jothie Begum Haseena Bethapudi Bharathi Ramasamy Selvam D’Souza Prashanth |
| author_sort | Boddapati Srinivasa Rao |
| collection | DOAJ |
| description | Herbal products are being used and trusted globally for thousands of years for their health benefits and limited side effects. Globally, a general belief amongst the consumers is that herbal supplements are always safe because they are “natural.” But later, research reveals that they may not be safe. This raises concern on their safety and implications for their use as feed supplement or medicine. Toxicity testing can reveal some of the risks that may be associated with use of herbs, therefore avoiding potential harmful effects. The present study was designed to investigate five poultry feed supplements (PFS), EGMAX® (to revitalize ovarian activity), FEED-X™ (feed efficiency enhancer), KOLIN PLUS™ (natural replacer of synthetic choline chloride), PHYTOCEE® (natural defence enhancer), and STODI® (to prevent and control loose droppings), for their possible mutagenicity and toxicity. Bacterial reverse mutation (BRMT) and acute oral toxicity tests were employed to assess the PFS for their possible mutagenicity and toxicity. Results indicated that the PFS were devoid of mutagenic effects in BRMT and showed higher safety profile in rodent acute oral toxicity test. |
| format | Article |
| id | doaj-art-7865d09d0cef46598ed134bd59447239 |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-7865d09d0cef46598ed134bd594472392025-02-03T05:51:53ZengWileyJournal of Toxicology1687-81911687-82052018-01-01201810.1155/2018/94121679412167Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed SupplementsBoddapati Srinivasa Rao0C. V. Chandrasekaran1H. S. Srikanth2Murugan Sasikumar3R. Edwin Jothie4Begum Haseena5Bethapudi Bharathi6Ramasamy Selvam7D’Souza Prashanth8R&D, Natural Remedies Pvt. Ltd., Plot No. 5B, Veerasandra Industrial Area, 19th KM Stone, Hosur Road, Bangalore, Karnataka 560100, IndiaR&D, Natural Remedies Pvt. Ltd., Plot No. 5B, Veerasandra Industrial Area, 19th KM Stone, Hosur Road, Bangalore, Karnataka 560100, IndiaR&D, Natural Remedies Pvt. Ltd., Plot No. 5B, Veerasandra Industrial Area, 19th KM Stone, Hosur Road, Bangalore, Karnataka 560100, IndiaR&D, Natural Remedies Pvt. Ltd., Plot No. 5B, Veerasandra Industrial Area, 19th KM Stone, Hosur Road, Bangalore, Karnataka 560100, IndiaR&D, Natural Remedies Pvt. Ltd., Plot No. 5B, Veerasandra Industrial Area, 19th KM Stone, Hosur Road, Bangalore, Karnataka 560100, IndiaR&D, Natural Remedies Pvt. Ltd., Plot No. 5B, Veerasandra Industrial Area, 19th KM Stone, Hosur Road, Bangalore, Karnataka 560100, IndiaR&D, Natural Remedies Pvt. Ltd., Plot No. 5B, Veerasandra Industrial Area, 19th KM Stone, Hosur Road, Bangalore, Karnataka 560100, IndiaR&D, Natural Remedies Pvt. Ltd., Plot No. 5B, Veerasandra Industrial Area, 19th KM Stone, Hosur Road, Bangalore, Karnataka 560100, IndiaR&D, Natural Remedies Pvt. Ltd., Plot No. 5B, Veerasandra Industrial Area, 19th KM Stone, Hosur Road, Bangalore, Karnataka 560100, IndiaHerbal products are being used and trusted globally for thousands of years for their health benefits and limited side effects. Globally, a general belief amongst the consumers is that herbal supplements are always safe because they are “natural.” But later, research reveals that they may not be safe. This raises concern on their safety and implications for their use as feed supplement or medicine. Toxicity testing can reveal some of the risks that may be associated with use of herbs, therefore avoiding potential harmful effects. The present study was designed to investigate five poultry feed supplements (PFS), EGMAX® (to revitalize ovarian activity), FEED-X™ (feed efficiency enhancer), KOLIN PLUS™ (natural replacer of synthetic choline chloride), PHYTOCEE® (natural defence enhancer), and STODI® (to prevent and control loose droppings), for their possible mutagenicity and toxicity. Bacterial reverse mutation (BRMT) and acute oral toxicity tests were employed to assess the PFS for their possible mutagenicity and toxicity. Results indicated that the PFS were devoid of mutagenic effects in BRMT and showed higher safety profile in rodent acute oral toxicity test.http://dx.doi.org/10.1155/2018/9412167 |
| spellingShingle | Boddapati Srinivasa Rao C. V. Chandrasekaran H. S. Srikanth Murugan Sasikumar R. Edwin Jothie Begum Haseena Bethapudi Bharathi Ramasamy Selvam D’Souza Prashanth Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed Supplements Journal of Toxicology |
| title | Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed Supplements |
| title_full | Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed Supplements |
| title_fullStr | Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed Supplements |
| title_full_unstemmed | Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed Supplements |
| title_short | Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed Supplements |
| title_sort | mutagenicity and acute oral toxicity test for herbal poultry feed supplements |
| url | http://dx.doi.org/10.1155/2018/9412167 |
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