Clinical and Bacterial Characteristics of Bloodstream Infections Caused by Listeria monocytogenes in Western China
Objective. Bloodstream infections (BSIs) caused by Listeria monocytogenes are linked to high mortality of the patients. Case-specific details related to this disease and causative strains in different districts remain to be characterized. Methods. In this study, medical data of BSIs admitted to West...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2024/7785327 |
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| author | Nan Wang Liuqing Yang Yu Yuan Chongyang Wu Chao He |
| author_facet | Nan Wang Liuqing Yang Yu Yuan Chongyang Wu Chao He |
| author_sort | Nan Wang |
| collection | DOAJ |
| description | Objective. Bloodstream infections (BSIs) caused by Listeria monocytogenes are linked to high mortality of the patients. Case-specific details related to this disease and causative strains in different districts remain to be characterized. Methods. In this study, medical data of BSIs admitted to West China Hospital from October 2017 to March 2023 were retrieved from the hospital information system. The in vitro antimicrobial susceptibility testing and whole-genome sequencing were performed for L. monocytogenes strains isolated from blood specimens. The genetic relationship of these strains with those in public databases was also analyzed. Result. The in-hospital mortality of L. monocytogenes BSIs was 25.7% (9/35). The changes in consciousness and elevated serum C-reactive protein (CRP) level were found to be the differential factors of L. monocytogenes BSIs (P<0.05). All the 27 strains studied were susceptible to ampicillin, meropenem, and erythromycin. Only 22.2% of them were susceptible to trimethoprim-sulfamethoxazole. The Listeria pathogenicity islands 1 (LIPI-1), truncated LIPI-2, and multiple virulence-related genes outside the LIPIs were determined from these strains. Also, 12 sequence types (STs) and 12 clonal complexes (CCs) were identified and classified into clonal lineages I (9/27, 33.3%) and lineages II (18/27, 66.7%), demonstrating genetic differences with the strains in the database. ST451/CC11 (5/27, 18.5%) and ST8/CC8 (4/27, 14.8%) were the common genotypes. Conclusions. The consciousness change and elevated serum CRP level were found to be the differential factors of L. monocytogenes BSIs. Considering the high virulence of the strains, it is needed to pay more attention to the dissemination of the predominant genotype. |
| format | Article |
| id | doaj-art-786555dda0764c028c5e6fcceb7052a7 |
| institution | Kabale University |
| issn | 1918-1493 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-786555dda0764c028c5e6fcceb7052a72025-08-20T03:35:12ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1918-14932024-01-01202410.1155/2024/7785327Clinical and Bacterial Characteristics of Bloodstream Infections Caused by Listeria monocytogenes in Western ChinaNan Wang0Liuqing Yang1Yu Yuan2Chongyang Wu3Chao He4Department of Laboratory MedicineDepartment of Laboratory MedicineDepartment of Laboratory MedicineDepartment of Laboratory MedicineDepartment of Laboratory MedicineObjective. Bloodstream infections (BSIs) caused by Listeria monocytogenes are linked to high mortality of the patients. Case-specific details related to this disease and causative strains in different districts remain to be characterized. Methods. In this study, medical data of BSIs admitted to West China Hospital from October 2017 to March 2023 were retrieved from the hospital information system. The in vitro antimicrobial susceptibility testing and whole-genome sequencing were performed for L. monocytogenes strains isolated from blood specimens. The genetic relationship of these strains with those in public databases was also analyzed. Result. The in-hospital mortality of L. monocytogenes BSIs was 25.7% (9/35). The changes in consciousness and elevated serum C-reactive protein (CRP) level were found to be the differential factors of L. monocytogenes BSIs (P<0.05). All the 27 strains studied were susceptible to ampicillin, meropenem, and erythromycin. Only 22.2% of them were susceptible to trimethoprim-sulfamethoxazole. The Listeria pathogenicity islands 1 (LIPI-1), truncated LIPI-2, and multiple virulence-related genes outside the LIPIs were determined from these strains. Also, 12 sequence types (STs) and 12 clonal complexes (CCs) were identified and classified into clonal lineages I (9/27, 33.3%) and lineages II (18/27, 66.7%), demonstrating genetic differences with the strains in the database. ST451/CC11 (5/27, 18.5%) and ST8/CC8 (4/27, 14.8%) were the common genotypes. Conclusions. The consciousness change and elevated serum CRP level were found to be the differential factors of L. monocytogenes BSIs. Considering the high virulence of the strains, it is needed to pay more attention to the dissemination of the predominant genotype.http://dx.doi.org/10.1155/2024/7785327 |
| spellingShingle | Nan Wang Liuqing Yang Yu Yuan Chongyang Wu Chao He Clinical and Bacterial Characteristics of Bloodstream Infections Caused by Listeria monocytogenes in Western China Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Clinical and Bacterial Characteristics of Bloodstream Infections Caused by Listeria monocytogenes in Western China |
| title_full | Clinical and Bacterial Characteristics of Bloodstream Infections Caused by Listeria monocytogenes in Western China |
| title_fullStr | Clinical and Bacterial Characteristics of Bloodstream Infections Caused by Listeria monocytogenes in Western China |
| title_full_unstemmed | Clinical and Bacterial Characteristics of Bloodstream Infections Caused by Listeria monocytogenes in Western China |
| title_short | Clinical and Bacterial Characteristics of Bloodstream Infections Caused by Listeria monocytogenes in Western China |
| title_sort | clinical and bacterial characteristics of bloodstream infections caused by listeria monocytogenes in western china |
| url | http://dx.doi.org/10.1155/2024/7785327 |
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