Association between triglyceride-glucose index and all-cause mortality in critically ill patients with acute myocardial infarction: analysis of the MIMIC-IV database
BackgroundCurrently, the clinical evidence regarding the prognostic significance of the TyG index in acute myocardial infarction (AMI) patients remains unclear. Our research analyzed the correlation between the TyG index and the risk of mortality in patients with AMI, in order to evaluate the influe...
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Frontiers Media S.A.
2025-01-01
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| author | Xin Su Yujing Zhou Jie Chang Xin Zhao Haiyu Li Haiqiang Sang |
| author_facet | Xin Su Yujing Zhou Jie Chang Xin Zhao Haiyu Li Haiqiang Sang |
| author_sort | Xin Su |
| collection | DOAJ |
| description | BackgroundCurrently, the clinical evidence regarding the prognostic significance of the TyG index in acute myocardial infarction (AMI) patients remains unclear. Our research analyzed the correlation between the TyG index and the risk of mortality in patients with AMI, in order to evaluate the influence of the TyG index on the prognosis of this population.Methods1205 ICU patients with AMI were analyzed in this retrospective cohort analysis, and the necessary data were obtained from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The study conducted Kaplan-Meier analysis to compare all-cause mortality rates across four groups of patients. The study included logistic regression and Cox regression analysis to examine the correlation among the TyG index and the risk of in-hospital, 28-day, and 90-day mortality.ResultsIn our study, 176 (14.61%) patients experienced in-hospital deaths, 198 (16.43%) patients died within 28 days of follow-up, and 189 (23.98%) patients died within 90 days of follow-up. Logistic regression and Cox proportional hazard analyses revealed that the TyG index was an independent predictor of in-hospital, 28-day, and 90-day mortality (OR: 1.406, 95% CI 1.141-1.731, p = 0.001; HR: 1.364, 95% CI 1.118-1.665, p = 0.002; HR: 1.221, 95% CI 1.024-1.445, p = 0.026, respectively). The restricted cubic spline regression model showed that the risk of in-hospital, 28-day, and 90-day mortality increased linearly with increasing TyG index.ConclusionsThe TyG index was significantly associated with an increased risk of mortality in AMI patients. Our findings suggested that the TyG index may be instrumental in identifying patients at high risk for adverse outcomes following AMI. |
| format | Article |
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| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-785bb3757f7b47c395e172cd76d6609b2025-01-22T05:19:51ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011610.3389/fendo.2025.14470531447053Association between triglyceride-glucose index and all-cause mortality in critically ill patients with acute myocardial infarction: analysis of the MIMIC-IV databaseXin Su0Yujing Zhou1Jie Chang2Xin Zhao3Haiyu Li4Haiqiang Sang5Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaNational Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaBackgroundCurrently, the clinical evidence regarding the prognostic significance of the TyG index in acute myocardial infarction (AMI) patients remains unclear. Our research analyzed the correlation between the TyG index and the risk of mortality in patients with AMI, in order to evaluate the influence of the TyG index on the prognosis of this population.Methods1205 ICU patients with AMI were analyzed in this retrospective cohort analysis, and the necessary data were obtained from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The study conducted Kaplan-Meier analysis to compare all-cause mortality rates across four groups of patients. The study included logistic regression and Cox regression analysis to examine the correlation among the TyG index and the risk of in-hospital, 28-day, and 90-day mortality.ResultsIn our study, 176 (14.61%) patients experienced in-hospital deaths, 198 (16.43%) patients died within 28 days of follow-up, and 189 (23.98%) patients died within 90 days of follow-up. Logistic regression and Cox proportional hazard analyses revealed that the TyG index was an independent predictor of in-hospital, 28-day, and 90-day mortality (OR: 1.406, 95% CI 1.141-1.731, p = 0.001; HR: 1.364, 95% CI 1.118-1.665, p = 0.002; HR: 1.221, 95% CI 1.024-1.445, p = 0.026, respectively). The restricted cubic spline regression model showed that the risk of in-hospital, 28-day, and 90-day mortality increased linearly with increasing TyG index.ConclusionsThe TyG index was significantly associated with an increased risk of mortality in AMI patients. Our findings suggested that the TyG index may be instrumental in identifying patients at high risk for adverse outcomes following AMI.https://www.frontiersin.org/articles/10.3389/fendo.2025.1447053/fulltriglyceride-glucose indexacute myocardial infarctioninsulin resistanceall-cause mortalityMIMIC-IV database |
| spellingShingle | Xin Su Yujing Zhou Jie Chang Xin Zhao Haiyu Li Haiqiang Sang Association between triglyceride-glucose index and all-cause mortality in critically ill patients with acute myocardial infarction: analysis of the MIMIC-IV database Frontiers in Endocrinology triglyceride-glucose index acute myocardial infarction insulin resistance all-cause mortality MIMIC-IV database |
| title | Association between triglyceride-glucose index and all-cause mortality in critically ill patients with acute myocardial infarction: analysis of the MIMIC-IV database |
| title_full | Association between triglyceride-glucose index and all-cause mortality in critically ill patients with acute myocardial infarction: analysis of the MIMIC-IV database |
| title_fullStr | Association between triglyceride-glucose index and all-cause mortality in critically ill patients with acute myocardial infarction: analysis of the MIMIC-IV database |
| title_full_unstemmed | Association between triglyceride-glucose index and all-cause mortality in critically ill patients with acute myocardial infarction: analysis of the MIMIC-IV database |
| title_short | Association between triglyceride-glucose index and all-cause mortality in critically ill patients with acute myocardial infarction: analysis of the MIMIC-IV database |
| title_sort | association between triglyceride glucose index and all cause mortality in critically ill patients with acute myocardial infarction analysis of the mimic iv database |
| topic | triglyceride-glucose index acute myocardial infarction insulin resistance all-cause mortality MIMIC-IV database |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1447053/full |
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