Langerhans Cell Histiocytosis Manifests with Acute Severe Hypernatremia during Hospitalization
Central diabetes insipidus (DI) is characterized by a deficiency in arginine vasopressin (AVP), an antidiuretic hormone leading to excessive free water loss in the urine and hypernatremia. Central DI can be the first presentation of several occult diseases. However, patients with central DI who have...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2022/6120644 |
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| author | Kullaya Takkavatakarn Hansamon Poparn Pisut Katavetin |
| author_facet | Kullaya Takkavatakarn Hansamon Poparn Pisut Katavetin |
| author_sort | Kullaya Takkavatakarn |
| collection | DOAJ |
| description | Central diabetes insipidus (DI) is characterized by a deficiency in arginine vasopressin (AVP), an antidiuretic hormone leading to excessive free water loss in the urine and hypernatremia. Central DI can be the first presentation of several occult diseases. However, patients with central DI who have functioning thirst mechanisms and access to water may initially exhibit normal sodium levels. We report a 57-year-old woman who was admitted to the hospital due to cholangitis. Her initial serum sodium was normal and she rapidly developed severe hypernatremia after fluid restriction. The results of the laboratory workup indicated DI, which dramatically responded to desmopressin. MRI showed an ill-defined faint hyper signal intensity in T1, T2/FLAIR lesions involving the bilateral hypothalamus. The histopathological findings confirmed the diagnosis of Langerhans cell histiocytosis (LCH) with multiorgan involvement. Serum sodium returned to normal after receiving desmopressin and water replacement therapy. |
| format | Article |
| id | doaj-art-78589915f26943cb9d516bd2d5a8de49 |
| institution | Kabale University |
| issn | 2090-665X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-78589915f26943cb9d516bd2d5a8de492025-02-03T06:08:41ZengWileyCase Reports in Nephrology2090-665X2022-01-01202210.1155/2022/6120644Langerhans Cell Histiocytosis Manifests with Acute Severe Hypernatremia during HospitalizationKullaya Takkavatakarn0Hansamon Poparn1Pisut Katavetin2Division of NephrologyDepartment of Pediatric Hematology and OncologyDivision of NephrologyCentral diabetes insipidus (DI) is characterized by a deficiency in arginine vasopressin (AVP), an antidiuretic hormone leading to excessive free water loss in the urine and hypernatremia. Central DI can be the first presentation of several occult diseases. However, patients with central DI who have functioning thirst mechanisms and access to water may initially exhibit normal sodium levels. We report a 57-year-old woman who was admitted to the hospital due to cholangitis. Her initial serum sodium was normal and she rapidly developed severe hypernatremia after fluid restriction. The results of the laboratory workup indicated DI, which dramatically responded to desmopressin. MRI showed an ill-defined faint hyper signal intensity in T1, T2/FLAIR lesions involving the bilateral hypothalamus. The histopathological findings confirmed the diagnosis of Langerhans cell histiocytosis (LCH) with multiorgan involvement. Serum sodium returned to normal after receiving desmopressin and water replacement therapy.http://dx.doi.org/10.1155/2022/6120644 |
| spellingShingle | Kullaya Takkavatakarn Hansamon Poparn Pisut Katavetin Langerhans Cell Histiocytosis Manifests with Acute Severe Hypernatremia during Hospitalization Case Reports in Nephrology |
| title | Langerhans Cell Histiocytosis Manifests with Acute Severe Hypernatremia during Hospitalization |
| title_full | Langerhans Cell Histiocytosis Manifests with Acute Severe Hypernatremia during Hospitalization |
| title_fullStr | Langerhans Cell Histiocytosis Manifests with Acute Severe Hypernatremia during Hospitalization |
| title_full_unstemmed | Langerhans Cell Histiocytosis Manifests with Acute Severe Hypernatremia during Hospitalization |
| title_short | Langerhans Cell Histiocytosis Manifests with Acute Severe Hypernatremia during Hospitalization |
| title_sort | langerhans cell histiocytosis manifests with acute severe hypernatremia during hospitalization |
| url | http://dx.doi.org/10.1155/2022/6120644 |
| work_keys_str_mv | AT kullayatakkavatakarn langerhanscellhistiocytosismanifestswithacuteseverehypernatremiaduringhospitalization AT hansamonpoparn langerhanscellhistiocytosismanifestswithacuteseverehypernatremiaduringhospitalization AT pisutkatavetin langerhanscellhistiocytosismanifestswithacuteseverehypernatremiaduringhospitalization |