A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole
The title compounds (7a-h) were prepared by esterification of indole-5-carboxylic acid (1) and subsequent treatment with hydrazine hydrate in methanol via the hydrazide (3). Finally hydrazide (3) condensed with different substituted aldol (6) in acetic acid / PTSA catalytic media produced (3,5-subsi...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/979401 |
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| author | K. Narasimha Sarma M. C. S. Subha K. Chowdoji Rao |
| author_facet | K. Narasimha Sarma M. C. S. Subha K. Chowdoji Rao |
| author_sort | K. Narasimha Sarma |
| collection | DOAJ |
| description | The title compounds (7a-h) were prepared by esterification of indole-5-carboxylic acid (1) and subsequent treatment with hydrazine hydrate in methanol via the hydrazide (3). Finally hydrazide (3) condensed with different substituted aldol (6) in acetic acid / PTSA catalytic media produced (3,5-subsituted-4,5-dihydropyrazol-1-yl)(1H-indol-5-yl)methanone (7a-h) in good yields. All the newly synthesized compounds are by elemental analysis and spectral studies and evaluated for antimicrobial activities. |
| format | Article |
| id | doaj-art-7851932c96cc44d882347e4b4f2439ea |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-7851932c96cc44d882347e4b4f2439ea2025-08-20T03:35:11ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-017374575010.1155/2010/979401A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying IndoleK. Narasimha Sarma0M. C. S. Subha1K. Chowdoji Rao2Department of Chemistry, Sri Krishnadevaraya University, Anantapur-515003, A.P., IndiaDepartment of Chemistry, Sri Krishnadevaraya University, Anantapur-515003, A.P., IndiaDepartment of Chemistry, Sri Krishnadevaraya University, Anantapur-515003, A.P., IndiaThe title compounds (7a-h) were prepared by esterification of indole-5-carboxylic acid (1) and subsequent treatment with hydrazine hydrate in methanol via the hydrazide (3). Finally hydrazide (3) condensed with different substituted aldol (6) in acetic acid / PTSA catalytic media produced (3,5-subsituted-4,5-dihydropyrazol-1-yl)(1H-indol-5-yl)methanone (7a-h) in good yields. All the newly synthesized compounds are by elemental analysis and spectral studies and evaluated for antimicrobial activities.http://dx.doi.org/10.1155/2010/979401 |
| spellingShingle | K. Narasimha Sarma M. C. S. Subha K. Chowdoji Rao A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole E-Journal of Chemistry |
| title | A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole |
| title_full | A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole |
| title_fullStr | A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole |
| title_full_unstemmed | A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole |
| title_short | A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole |
| title_sort | facial synthesis and antimicrobial activity of some pyrazole derivatives carrying indole |
| url | http://dx.doi.org/10.1155/2010/979401 |
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