Kinetic Study of Acid-Catalyzed Knoevenagel Condensation Between 5-Methoxy-1-Tetralone and Glyoxylic Acid
In this work we present, a kinetic study of the Knoevenagel condensation reaction between 5-methoxy-1-tetralone and glyoxylic acid, catalyzed by sulfuric acid, to produce (<i>E</i>)-2-(5-methoxy-1-oxo-3,4-dihydronaphthalen-2(1<i>H</i>)-ylidene)acetic acid. The reaction was ca...
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2024-11-01
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| author | Michelle E. Herrera Elvia V. Cabrera Roger S. Guanoluisa Ullrich Stahl |
| author_facet | Michelle E. Herrera Elvia V. Cabrera Roger S. Guanoluisa Ullrich Stahl |
| author_sort | Michelle E. Herrera |
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| description | In this work we present, a kinetic study of the Knoevenagel condensation reaction between 5-methoxy-1-tetralone and glyoxylic acid, catalyzed by sulfuric acid, to produce (<i>E</i>)-2-(5-methoxy-1-oxo-3,4-dihydronaphthalen-2(1<i>H</i>)-ylidene)acetic acid. The reaction was carried out in a batch system at 400 rpm for 24 h at temperatures of 75, 80 and 85 °C. The yields obtained at these temperatures were 90.30, 93.75 and 94.16%, respectively. The reaction was monitored by TLC and HPLC. For the kinetic analysis, three mathematical methods were used: integral, differential and non-linear regression. The results showed an excellent fit of the experimental data to the pseudo-first-order kinetic model. |
| format | Article |
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| institution | OA Journals |
| issn | 2673-4583 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Chemistry Proceedings |
| spelling | doaj-art-784e137d3bd346b89d041902c6d06c832025-08-20T02:24:19ZengMDPI AGChemistry Proceedings2673-45832024-11-0116110010.3390/ecsoc-28-20255Kinetic Study of Acid-Catalyzed Knoevenagel Condensation Between 5-Methoxy-1-Tetralone and Glyoxylic AcidMichelle E. Herrera0Elvia V. Cabrera1Roger S. Guanoluisa2Ullrich Stahl3Research Group on Food, Organic Compounds, Materials, Applied Microbiology and Energy (ACMME), Faculty of Chemical Engineering, Universidad Central del Ecuador, Enrique Ritter s/n y Bolivia, Quito 170521, EcuadorResearch Group on Food, Organic Compounds, Materials, Applied Microbiology and Energy (ACMME), Faculty of Chemical Engineering, Universidad Central del Ecuador, Enrique Ritter s/n y Bolivia, Quito 170521, EcuadorFaculty of Chemical Engineering, Universidad Central del Ecuador, Enrique Ritter s/n y Bolivia, Quito 170521, EcuadorResearch Group on Food, Organic Compounds, Materials, Applied Microbiology and Energy (ACMME), Faculty of Chemical Engineering, Universidad Central del Ecuador, Enrique Ritter s/n y Bolivia, Quito 170521, EcuadorIn this work we present, a kinetic study of the Knoevenagel condensation reaction between 5-methoxy-1-tetralone and glyoxylic acid, catalyzed by sulfuric acid, to produce (<i>E</i>)-2-(5-methoxy-1-oxo-3,4-dihydronaphthalen-2(1<i>H</i>)-ylidene)acetic acid. The reaction was carried out in a batch system at 400 rpm for 24 h at temperatures of 75, 80 and 85 °C. The yields obtained at these temperatures were 90.30, 93.75 and 94.16%, respectively. The reaction was monitored by TLC and HPLC. For the kinetic analysis, three mathematical methods were used: integral, differential and non-linear regression. The results showed an excellent fit of the experimental data to the pseudo-first-order kinetic model.https://www.mdpi.com/2673-4583/16/1/100kinetic studyacid catalyzedKnoevenagel condensation1-tetralone |
| spellingShingle | Michelle E. Herrera Elvia V. Cabrera Roger S. Guanoluisa Ullrich Stahl Kinetic Study of Acid-Catalyzed Knoevenagel Condensation Between 5-Methoxy-1-Tetralone and Glyoxylic Acid Chemistry Proceedings kinetic study acid catalyzed Knoevenagel condensation 1-tetralone |
| title | Kinetic Study of Acid-Catalyzed Knoevenagel Condensation Between 5-Methoxy-1-Tetralone and Glyoxylic Acid |
| title_full | Kinetic Study of Acid-Catalyzed Knoevenagel Condensation Between 5-Methoxy-1-Tetralone and Glyoxylic Acid |
| title_fullStr | Kinetic Study of Acid-Catalyzed Knoevenagel Condensation Between 5-Methoxy-1-Tetralone and Glyoxylic Acid |
| title_full_unstemmed | Kinetic Study of Acid-Catalyzed Knoevenagel Condensation Between 5-Methoxy-1-Tetralone and Glyoxylic Acid |
| title_short | Kinetic Study of Acid-Catalyzed Knoevenagel Condensation Between 5-Methoxy-1-Tetralone and Glyoxylic Acid |
| title_sort | kinetic study of acid catalyzed knoevenagel condensation between 5 methoxy 1 tetralone and glyoxylic acid |
| topic | kinetic study acid catalyzed Knoevenagel condensation 1-tetralone |
| url | https://www.mdpi.com/2673-4583/16/1/100 |
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