Organ-on-a-Chip Applications in Microfluidic Platforms
Microfluidic technology plays a crucial role in organ-on-a-chip (OoC) systems by replicating human physiological processes and disease states, significantly advancing biomedical research and drug discovery. This article reviews the design and fabrication processes of microfluidic devices. It also ex...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/16/2/201 |
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| author | Ling An Yi Liu Yaling Liu |
| author_facet | Ling An Yi Liu Yaling Liu |
| author_sort | Ling An |
| collection | DOAJ |
| description | Microfluidic technology plays a crucial role in organ-on-a-chip (OoC) systems by replicating human physiological processes and disease states, significantly advancing biomedical research and drug discovery. This article reviews the design and fabrication processes of microfluidic devices. It also explores how these technologies are integrated into OoC platforms to simulate human physiological environments, highlighting key principles, technological advances, and diverse applications. Through case studies involving the simulation of multiple organs such as the heart, liver, and lungs, the article evaluates the impact of OoC systems’ integrated microfluidic technology on drug screening, toxicity assessment, and personalized medicine. In addition, this article considers technical challenges, ethical issues, and future directions, and looks ahead to further optimizing the functionality and biomimetic precision of OoCs through innovation, emphasizing its critical role in promoting personalized medicine and precision treatment strategies. |
| format | Article |
| id | doaj-art-784b9ca7580b4e888b42d47d3f0eb9e3 |
| institution | DOAJ |
| issn | 2072-666X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj-art-784b9ca7580b4e888b42d47d3f0eb9e32025-08-20T02:44:35ZengMDPI AGMicromachines2072-666X2025-02-0116220110.3390/mi16020201Organ-on-a-Chip Applications in Microfluidic PlatformsLing An0Yi Liu1Yaling Liu2School of Engineering, Dali University, Dali 671003, ChinaSchool of Engineering, Dali University, Dali 671003, ChinaPrecision Medicine Translational Research Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaMicrofluidic technology plays a crucial role in organ-on-a-chip (OoC) systems by replicating human physiological processes and disease states, significantly advancing biomedical research and drug discovery. This article reviews the design and fabrication processes of microfluidic devices. It also explores how these technologies are integrated into OoC platforms to simulate human physiological environments, highlighting key principles, technological advances, and diverse applications. Through case studies involving the simulation of multiple organs such as the heart, liver, and lungs, the article evaluates the impact of OoC systems’ integrated microfluidic technology on drug screening, toxicity assessment, and personalized medicine. In addition, this article considers technical challenges, ethical issues, and future directions, and looks ahead to further optimizing the functionality and biomimetic precision of OoCs through innovation, emphasizing its critical role in promoting personalized medicine and precision treatment strategies.https://www.mdpi.com/2072-666X/16/2/201microfluidicsorgan-on-a-chip (OoC)drug developmentdisease modelingpersonalized medicine |
| spellingShingle | Ling An Yi Liu Yaling Liu Organ-on-a-Chip Applications in Microfluidic Platforms Micromachines microfluidics organ-on-a-chip (OoC) drug development disease modeling personalized medicine |
| title | Organ-on-a-Chip Applications in Microfluidic Platforms |
| title_full | Organ-on-a-Chip Applications in Microfluidic Platforms |
| title_fullStr | Organ-on-a-Chip Applications in Microfluidic Platforms |
| title_full_unstemmed | Organ-on-a-Chip Applications in Microfluidic Platforms |
| title_short | Organ-on-a-Chip Applications in Microfluidic Platforms |
| title_sort | organ on a chip applications in microfluidic platforms |
| topic | microfluidics organ-on-a-chip (OoC) drug development disease modeling personalized medicine |
| url | https://www.mdpi.com/2072-666X/16/2/201 |
| work_keys_str_mv | AT lingan organonachipapplicationsinmicrofluidicplatforms AT yiliu organonachipapplicationsinmicrofluidicplatforms AT yalingliu organonachipapplicationsinmicrofluidicplatforms |