Outcomes associated with fetal nuchal translucency between 3.0 and 3.4 mm in the first trimester
Abstract Introduction Decisions concerning nuchal translucency (NT) between 3.0 and 3.4 mm remain controversial, particularly regarding whether to first calculate the combined first trimester screening test or to proceed directly with invasive testing. The literature suggests an increased risk of ch...
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2025-04-01
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| Series: | Acta Obstetricia et Gynecologica Scandinavica |
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| Online Access: | https://doi.org/10.1111/aogs.15055 |
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| author | Manon D. E. Vriendt Caroline Rooryck Hugo Madar Frédéric Coatleven Marie Vincienne Perrine Prier Sophie Naudion Loïc Sentilhes Hanane Bouchghoul |
| author_facet | Manon D. E. Vriendt Caroline Rooryck Hugo Madar Frédéric Coatleven Marie Vincienne Perrine Prier Sophie Naudion Loïc Sentilhes Hanane Bouchghoul |
| author_sort | Manon D. E. Vriendt |
| collection | DOAJ |
| description | Abstract Introduction Decisions concerning nuchal translucency (NT) between 3.0 and 3.4 mm remain controversial, particularly regarding whether to first calculate the combined first trimester screening test or to proceed directly with invasive testing. The literature suggests an increased risk of chromosomal aberration, as well as pathogenic copy number variations (CNVs) on chromosomal microarray, for fetuses with NT between 3.0 and 3.4 mm. The aim of this study was to describe genetic findings of fetuses with NT between 3.0 and 3.4 mm in the first trimester. The secondary objective was to describe ultrasound findings and adverse outcomes for these fetuses. The third objective was to compare genetic, ultrasound findings and adverse outcomes of fetuses with NT between 3.0 and 3.4 mm to those with NT ≥3.5 mm. Material and Methods We conducted an observational, retrospective study in a referral center between 2017 and 2022. Genetic and ultrasound findings were compared between fetuses with NT between 3.0 and 3.4 mm and those with NT≥3.5 mm. An adverse outcome was defined as one of the following: miscarriage, perinatal death (stillbirth or neonatal death) or termination of pregnancy at parental request, and all major abnormalities or genetic disorders diagnosed before or after delivery. Results We included 404 fetuses with NT≥3.0 mm who had invasive testing with available karyotype and chromosomal microarray, among whom 20.8% (84/404) had NT between 3.0 and 3.4 mm. The rate of adverse outcomes among fetuses with NT between 3.0 and 3.4 mm was 32.1% (27/84). The rates of chromosomal aberration, pathogenic CNVs, and major ultrasound abnormalities were 16.7% (14/84), 6.0%(5/84), and 9.2% (6/65), respectively, for fetuses with NT between 3.0 and 3.4 mm. In comparison, fetuses with NT greater than 3.5 mm had higher rates of chromosomal aberration and major ultrasound abnormalities, with rates of 47.5% (152/320) and 30.2% (49/162) respectively compared to 16.7% (14/84) and 9.2% (6/65) for fetuses with NT between 3.0 and 3.4 mm (p < 0.001 for both comparisons). However, the rate of pathogenic CNVs was not significantly different between the two groups, with rates of 1.9% (6/320) for NT≥3.5 mm and 6.0% (5/84) for NT between 3.0 and 3.4 mm (p = 0.06). Conclusions The rate of chromosomal aberration and pathogenic CNVs on chromosomal microarray is high among fetuses with NT between 3.0 and 3.4 mm, although these rates remain lower than those observed among fetuses with NT≥3.5 mm. |
| format | Article |
| id | doaj-art-784afc86e1ca42149609ed31ddb9ccfe |
| institution | Kabale University |
| issn | 0001-6349 1600-0412 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
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| series | Acta Obstetricia et Gynecologica Scandinavica |
| spelling | doaj-art-784afc86e1ca42149609ed31ddb9ccfe2025-08-20T03:31:01ZengWileyActa Obstetricia et Gynecologica Scandinavica0001-63491600-04122025-04-01104462963610.1111/aogs.15055Outcomes associated with fetal nuchal translucency between 3.0 and 3.4 mm in the first trimesterManon D. E. Vriendt0Caroline Rooryck1Hugo Madar2Frédéric Coatleven3Marie Vincienne4Perrine Prier5Sophie Naudion6Loïc Sentilhes7Hanane Bouchghoul8Department of Obstetrics Bordeaux University Hospital Bordeaux FranceDepartment of Genetics Bordeaux University Hospital Bordeaux FranceDepartment of Obstetrics Bordeaux University Hospital Bordeaux FranceDepartment of Obstetrics Bordeaux University Hospital Bordeaux FranceDepartment of Obstetrics Bordeaux University Hospital Bordeaux FranceDepartment of Obstetrics Bordeaux University Hospital Bordeaux FranceDepartment of Genetics Bordeaux University Hospital Bordeaux FranceDepartment of Obstetrics Bordeaux University Hospital Bordeaux FranceDepartment of Obstetrics Bordeaux University Hospital Bordeaux FranceAbstract Introduction Decisions concerning nuchal translucency (NT) between 3.0 and 3.4 mm remain controversial, particularly regarding whether to first calculate the combined first trimester screening test or to proceed directly with invasive testing. The literature suggests an increased risk of chromosomal aberration, as well as pathogenic copy number variations (CNVs) on chromosomal microarray, for fetuses with NT between 3.0 and 3.4 mm. The aim of this study was to describe genetic findings of fetuses with NT between 3.0 and 3.4 mm in the first trimester. The secondary objective was to describe ultrasound findings and adverse outcomes for these fetuses. The third objective was to compare genetic, ultrasound findings and adverse outcomes of fetuses with NT between 3.0 and 3.4 mm to those with NT ≥3.5 mm. Material and Methods We conducted an observational, retrospective study in a referral center between 2017 and 2022. Genetic and ultrasound findings were compared between fetuses with NT between 3.0 and 3.4 mm and those with NT≥3.5 mm. An adverse outcome was defined as one of the following: miscarriage, perinatal death (stillbirth or neonatal death) or termination of pregnancy at parental request, and all major abnormalities or genetic disorders diagnosed before or after delivery. Results We included 404 fetuses with NT≥3.0 mm who had invasive testing with available karyotype and chromosomal microarray, among whom 20.8% (84/404) had NT between 3.0 and 3.4 mm. The rate of adverse outcomes among fetuses with NT between 3.0 and 3.4 mm was 32.1% (27/84). The rates of chromosomal aberration, pathogenic CNVs, and major ultrasound abnormalities were 16.7% (14/84), 6.0%(5/84), and 9.2% (6/65), respectively, for fetuses with NT between 3.0 and 3.4 mm. In comparison, fetuses with NT greater than 3.5 mm had higher rates of chromosomal aberration and major ultrasound abnormalities, with rates of 47.5% (152/320) and 30.2% (49/162) respectively compared to 16.7% (14/84) and 9.2% (6/65) for fetuses with NT between 3.0 and 3.4 mm (p < 0.001 for both comparisons). However, the rate of pathogenic CNVs was not significantly different between the two groups, with rates of 1.9% (6/320) for NT≥3.5 mm and 6.0% (5/84) for NT between 3.0 and 3.4 mm (p = 0.06). Conclusions The rate of chromosomal aberration and pathogenic CNVs on chromosomal microarray is high among fetuses with NT between 3.0 and 3.4 mm, although these rates remain lower than those observed among fetuses with NT≥3.5 mm.https://doi.org/10.1111/aogs.15055chromosomal aberrationschromosomal microarraycopy number variationsnuchal translucencyprenatal diagnosis |
| spellingShingle | Manon D. E. Vriendt Caroline Rooryck Hugo Madar Frédéric Coatleven Marie Vincienne Perrine Prier Sophie Naudion Loïc Sentilhes Hanane Bouchghoul Outcomes associated with fetal nuchal translucency between 3.0 and 3.4 mm in the first trimester Acta Obstetricia et Gynecologica Scandinavica chromosomal aberrations chromosomal microarray copy number variations nuchal translucency prenatal diagnosis |
| title | Outcomes associated with fetal nuchal translucency between 3.0 and 3.4 mm in the first trimester |
| title_full | Outcomes associated with fetal nuchal translucency between 3.0 and 3.4 mm in the first trimester |
| title_fullStr | Outcomes associated with fetal nuchal translucency between 3.0 and 3.4 mm in the first trimester |
| title_full_unstemmed | Outcomes associated with fetal nuchal translucency between 3.0 and 3.4 mm in the first trimester |
| title_short | Outcomes associated with fetal nuchal translucency between 3.0 and 3.4 mm in the first trimester |
| title_sort | outcomes associated with fetal nuchal translucency between 3 0 and 3 4 mm in the first trimester |
| topic | chromosomal aberrations chromosomal microarray copy number variations nuchal translucency prenatal diagnosis |
| url | https://doi.org/10.1111/aogs.15055 |
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