Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial
Objective To investigate the effect of pharmacist-led medicines management in multimorbid, hospitalised patients on long-term hospital readmissions and survival.Design Parallel-group, randomised controlled trial.Setting Recruitment from an internal medicine hospital ward in Oslo, Norway. Patients we...
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| Format: | Article |
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BMJ Publishing Group
2020-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/12/e041558.full |
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| author | Eva Skovlund Liv Mathiesen Marianne Lea Morten Mowé Espen Molden Kristin Kvernrød |
| author_facet | Eva Skovlund Liv Mathiesen Marianne Lea Morten Mowé Espen Molden Kristin Kvernrød |
| author_sort | Eva Skovlund |
| collection | DOAJ |
| description | Objective To investigate the effect of pharmacist-led medicines management in multimorbid, hospitalised patients on long-term hospital readmissions and survival.Design Parallel-group, randomised controlled trial.Setting Recruitment from an internal medicine hospital ward in Oslo, Norway. Patients were enrolled consecutively from August 2014 to the predetermined target number of 400 patients. The last participant was enrolled March 2016. Follow-up until 31 December 2017, that is, 21–40 months.Participants Acutely admitted multimorbid patients ≥18 years, using minimum four regular drugs from minimum two therapeutic classes. 399 patients were randomly assigned, 1:1, to the intervention or control group. After excluding 11 patients dying in-hospital and 2 erroneously included, the primary analysis comprised 386 patients (193 in each group) with median age 79 years (range 23–96) and number of diseases 7 (range 2–17).Intervention Intervention patients received pharmacist-led medicines management comprising medicines reconciliation at admission, repeated medicines reviews throughout the stay and medicines reconciliation and tailored information at discharge, according to the integrated medicines management model. Control patients received standard care.Primary and secondary outcome measures The primary endpoint was difference in time to readmission or death within 12 months. Overall survival was a priori the clinically most important secondary endpoint.Results Pharmacist-led medicines management had no significant effect on the primary endpoint time to readmission or death within 12 months (median 116 vs 184 days, HR 0.82, 95% CI 0.64 to 1.04, p=0.106). A statistically significantly increased overall survival was observed during 21–40 months follow-up (HR 0.66, 95% CI 0.48 to 0.90, p=0.008).Conclusions Pharmacist-led medicines management had no statistically significant effect on time until readmission or death. A statistically significant increased overall survival was seen. Further studies should be conducted to investigate the effect of such an intervention on a larger scale.Trial registration number NCT02336113. |
| format | Article |
| id | doaj-art-784a5ec6500944cd957de7a8284a01c1 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-784a5ec6500944cd957de7a8284a01c12024-11-22T13:40:11ZengBMJ Publishing GroupBMJ Open2044-60552020-12-01101210.1136/bmjopen-2020-041558Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trialEva Skovlund0Liv Mathiesen1Marianne Lea2Morten Mowé3Espen Molden4Kristin Kvernrød5Department of Public Health and Nursing, Norwegian University of Science and Technology NTNU, Trondheim, NorwayHospital Pharmacies Enterprise, South Eastern Norway, Oslo, NorwayDepartment of Pharmaceutical Services, Oslo Hospital Pharmacy, Hospital Pharmacies Enterprise, South Eastern Norway, Oslo, NorwayDivision of Medicine, Oslo University Hospital, Oslo, NorwayDepartment of Pharmacy, Section for Pharmacology and Pharmaceutical Biosciences, University of Oslo, Oslo, NorwayDepartment of Pharmaceutical Services, Oslo Hospital Pharmacy, Hospital Pharmacies Enterprise, South Eastern Norway, Oslo, NorwayObjective To investigate the effect of pharmacist-led medicines management in multimorbid, hospitalised patients on long-term hospital readmissions and survival.Design Parallel-group, randomised controlled trial.Setting Recruitment from an internal medicine hospital ward in Oslo, Norway. Patients were enrolled consecutively from August 2014 to the predetermined target number of 400 patients. The last participant was enrolled March 2016. Follow-up until 31 December 2017, that is, 21–40 months.Participants Acutely admitted multimorbid patients ≥18 years, using minimum four regular drugs from minimum two therapeutic classes. 399 patients were randomly assigned, 1:1, to the intervention or control group. After excluding 11 patients dying in-hospital and 2 erroneously included, the primary analysis comprised 386 patients (193 in each group) with median age 79 years (range 23–96) and number of diseases 7 (range 2–17).Intervention Intervention patients received pharmacist-led medicines management comprising medicines reconciliation at admission, repeated medicines reviews throughout the stay and medicines reconciliation and tailored information at discharge, according to the integrated medicines management model. Control patients received standard care.Primary and secondary outcome measures The primary endpoint was difference in time to readmission or death within 12 months. Overall survival was a priori the clinically most important secondary endpoint.Results Pharmacist-led medicines management had no significant effect on the primary endpoint time to readmission or death within 12 months (median 116 vs 184 days, HR 0.82, 95% CI 0.64 to 1.04, p=0.106). A statistically significantly increased overall survival was observed during 21–40 months follow-up (HR 0.66, 95% CI 0.48 to 0.90, p=0.008).Conclusions Pharmacist-led medicines management had no statistically significant effect on time until readmission or death. A statistically significant increased overall survival was seen. Further studies should be conducted to investigate the effect of such an intervention on a larger scale.Trial registration number NCT02336113.https://bmjopen.bmj.com/content/10/12/e041558.full |
| spellingShingle | Eva Skovlund Liv Mathiesen Marianne Lea Morten Mowé Espen Molden Kristin Kvernrød Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial BMJ Open |
| title | Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial |
| title_full | Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial |
| title_fullStr | Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial |
| title_full_unstemmed | Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial |
| title_short | Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial |
| title_sort | effect of medicines management versus standard care on readmissions in multimorbid patients a randomised controlled trial |
| url | https://bmjopen.bmj.com/content/10/12/e041558.full |
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