Preliminary investigations of plasma lipidome and selenium levels in adults with treated hypothyroidism and in healthy individuals without selenium deficiency
Abstract The present preliminary study aimed to provide a targeted lipidomic analysis of Hashimoto (HT) and non-HT patients with well-controlled hypothyroidism as well as in healthy adults, and is the first to demonstrate the association of several components of the human lipidome with hypothyroidis...
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Nature Portfolio
2024-11-01
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| Online Access: | https://doi.org/10.1038/s41598-024-80862-9 |
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| author | Anna Błażewicz Julia Wojnicka Andreas M. Grabrucker Piotr Sosnowski Alicja Trzpil Anna Kozub-Pędrak Klaudia Szałaj Agnieszka Szmagara Ewelina Grywalska Katarzyna Skórzyńska-Dziduszko |
| author_facet | Anna Błażewicz Julia Wojnicka Andreas M. Grabrucker Piotr Sosnowski Alicja Trzpil Anna Kozub-Pędrak Klaudia Szałaj Agnieszka Szmagara Ewelina Grywalska Katarzyna Skórzyńska-Dziduszko |
| author_sort | Anna Błażewicz |
| collection | DOAJ |
| description | Abstract The present preliminary study aimed to provide a targeted lipidomic analysis of Hashimoto (HT) and non-HT patients with well-controlled hypothyroidism as well as in healthy adults, and is the first to demonstrate the association of several components of the human lipidome with hypothyroidism in relation to the total plasma selenium content. All the patients and age-, sex-, and BMI-matched healthy controls met the very strict qualification criteria. Se levels were analyzed by ICP-MS, and lipidome studies were conducted using TQ-LC/MS. The 40 acylcarnitines, 90 glycerophospholipids, and 15 sphingomyelins were identified and quantified. PCaaC26:0 and PCaaC40:1 were negatively correlated with Se concentrations. Other lipids that were negatively correlated with Se concentrations but did not present significant differences between the three groups in the Kruskal–Wallis ANOVA test were PCaaC32:0, PCaeC30:0, PCaeC36:5, SMC18:0, and SM C18:1. In the multiple linear regression analyses, Se levels showed negative relationship, whereas different phosphatidylcholines: PCaaC24:0, PCaaC26:0, PCaeC30:1, PCaeC34:0, PCaeC36:4, PCaeC42:0 were positively associated with the presence of (H). Different lipidome components were identified in healthy and hypothyroid patients regardless of the cause of that condition. Studies on larger populations are needed to determine cause-and-effect relations and the potential mechanisms underlying these associations. |
| format | Article |
| id | doaj-art-783eea637ff6442ca5f058216ae1d363 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-783eea637ff6442ca5f058216ae1d3632025-08-20T02:08:15ZengNature PortfolioScientific Reports2045-23222024-11-0114112010.1038/s41598-024-80862-9Preliminary investigations of plasma lipidome and selenium levels in adults with treated hypothyroidism and in healthy individuals without selenium deficiencyAnna Błażewicz0Julia Wojnicka1Andreas M. Grabrucker2Piotr Sosnowski3Alicja Trzpil4Anna Kozub-Pędrak5Klaudia Szałaj6Agnieszka Szmagara7Ewelina Grywalska8Katarzyna Skórzyńska-Dziduszko9Department of Pathobiochemistry and Interdisciplinary Applications of Ion Chromatography, Chair of Biomedical Sciences, Medical University of LublinDepartment of Pathobiochemistry and Interdisciplinary Applications of Ion Chromatography, Chair of Biomedical Sciences, Medical University of LublinDepartment of Biological Sciences, University of LimerickDepartment of Bioanalytics, Medical University of LublinDepartment of Bioanalytics, Medical University of LublinDepartment of Bioanalytics, Medical University of LublinDepartment of Bioanalytics, Medical University of LublinFaculty of Medicine, Institute of Biological Sciences, Department of Chemistry, The John Paul II Catholic University of LublinDepartment of Experimental Immunology, Medical University of LublinDepartment of Human Physiology, Medical University of LublinAbstract The present preliminary study aimed to provide a targeted lipidomic analysis of Hashimoto (HT) and non-HT patients with well-controlled hypothyroidism as well as in healthy adults, and is the first to demonstrate the association of several components of the human lipidome with hypothyroidism in relation to the total plasma selenium content. All the patients and age-, sex-, and BMI-matched healthy controls met the very strict qualification criteria. Se levels were analyzed by ICP-MS, and lipidome studies were conducted using TQ-LC/MS. The 40 acylcarnitines, 90 glycerophospholipids, and 15 sphingomyelins were identified and quantified. PCaaC26:0 and PCaaC40:1 were negatively correlated with Se concentrations. Other lipids that were negatively correlated with Se concentrations but did not present significant differences between the three groups in the Kruskal–Wallis ANOVA test were PCaaC32:0, PCaeC30:0, PCaeC36:5, SMC18:0, and SM C18:1. In the multiple linear regression analyses, Se levels showed negative relationship, whereas different phosphatidylcholines: PCaaC24:0, PCaaC26:0, PCaeC30:1, PCaeC34:0, PCaeC36:4, PCaeC42:0 were positively associated with the presence of (H). Different lipidome components were identified in healthy and hypothyroid patients regardless of the cause of that condition. Studies on larger populations are needed to determine cause-and-effect relations and the potential mechanisms underlying these associations.https://doi.org/10.1038/s41598-024-80862-9Human plasma lipidomeSeleniumHypothyroidism |
| spellingShingle | Anna Błażewicz Julia Wojnicka Andreas M. Grabrucker Piotr Sosnowski Alicja Trzpil Anna Kozub-Pędrak Klaudia Szałaj Agnieszka Szmagara Ewelina Grywalska Katarzyna Skórzyńska-Dziduszko Preliminary investigations of plasma lipidome and selenium levels in adults with treated hypothyroidism and in healthy individuals without selenium deficiency Scientific Reports Human plasma lipidome Selenium Hypothyroidism |
| title | Preliminary investigations of plasma lipidome and selenium levels in adults with treated hypothyroidism and in healthy individuals without selenium deficiency |
| title_full | Preliminary investigations of plasma lipidome and selenium levels in adults with treated hypothyroidism and in healthy individuals without selenium deficiency |
| title_fullStr | Preliminary investigations of plasma lipidome and selenium levels in adults with treated hypothyroidism and in healthy individuals without selenium deficiency |
| title_full_unstemmed | Preliminary investigations of plasma lipidome and selenium levels in adults with treated hypothyroidism and in healthy individuals without selenium deficiency |
| title_short | Preliminary investigations of plasma lipidome and selenium levels in adults with treated hypothyroidism and in healthy individuals without selenium deficiency |
| title_sort | preliminary investigations of plasma lipidome and selenium levels in adults with treated hypothyroidism and in healthy individuals without selenium deficiency |
| topic | Human plasma lipidome Selenium Hypothyroidism |
| url | https://doi.org/10.1038/s41598-024-80862-9 |
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