Proton-Sensing G Protein-Coupled Receptors and Their Potential Role in Exercise Regulation of Arterial Function
During periods of exercise, the primary cause of metabolic acidosis is the accumulation of lactate from anaerobic metabolism, whereas a transient increase in CO<sub>2</sub> triggers a mild respiratory acidosis through the production of carbonic acid (H<sub>2</sub>CO<sub>...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/15/6/813 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850156022073655296 |
|---|---|
| author | Fengzhi Yu Dandan Jia Ru Wang |
| author_facet | Fengzhi Yu Dandan Jia Ru Wang |
| author_sort | Fengzhi Yu |
| collection | DOAJ |
| description | During periods of exercise, the primary cause of metabolic acidosis is the accumulation of lactate from anaerobic metabolism, whereas a transient increase in CO<sub>2</sub> triggers a mild respiratory acidosis through the production of carbonic acid (H<sub>2</sub>CO<sub>3</sub>). The combined effects of these reactions result in a slight acidifying shift in arterial blood pH. Proton-sensing G protein-coupled receptors (including GPR68, GPR4, GPR132, and GPR65) represent the primary receptors within the body for detecting alterations in extracellular proton concentrations. These receptors have been demonstrated to possess potential roles in mechanosensation, intestinal inflammation, oncoimmunological interactions, hematopoiesis, as well as inflammatory and neuropathic pain. Recent studies have shown that the activation or inhibition of these receptors modulates a number of arterial functions, including angiogenesis, arterial relaxation, and arterial inflammation. It is well established that moderate exercise has a beneficial effect on the regulation of arterial function. This study examines the effect of exercise on proton concentrations in the microenvironment of the organism and its influence on proton-sensing G protein-coupled receptors located on cell membranes, as well as possible mechanisms involved in the regulation of arterial function. The objective is to present novel perspectives for the exploration of potential drug targets for the prevention and treatment of arterial dysfunction and the development of exercise regimens. |
| format | Article |
| id | doaj-art-783c4b31f2cc456895ed405468bf5ea2 |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-783c4b31f2cc456895ed405468bf5ea22025-08-20T02:24:42ZengMDPI AGBiomolecules2218-273X2025-06-0115681310.3390/biom15060813Proton-Sensing G Protein-Coupled Receptors and Their Potential Role in Exercise Regulation of Arterial FunctionFengzhi Yu0Dandan Jia1Ru Wang2School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai 200438, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai 200438, ChinaDuring periods of exercise, the primary cause of metabolic acidosis is the accumulation of lactate from anaerobic metabolism, whereas a transient increase in CO<sub>2</sub> triggers a mild respiratory acidosis through the production of carbonic acid (H<sub>2</sub>CO<sub>3</sub>). The combined effects of these reactions result in a slight acidifying shift in arterial blood pH. Proton-sensing G protein-coupled receptors (including GPR68, GPR4, GPR132, and GPR65) represent the primary receptors within the body for detecting alterations in extracellular proton concentrations. These receptors have been demonstrated to possess potential roles in mechanosensation, intestinal inflammation, oncoimmunological interactions, hematopoiesis, as well as inflammatory and neuropathic pain. Recent studies have shown that the activation or inhibition of these receptors modulates a number of arterial functions, including angiogenesis, arterial relaxation, and arterial inflammation. It is well established that moderate exercise has a beneficial effect on the regulation of arterial function. This study examines the effect of exercise on proton concentrations in the microenvironment of the organism and its influence on proton-sensing G protein-coupled receptors located on cell membranes, as well as possible mechanisms involved in the regulation of arterial function. The objective is to present novel perspectives for the exploration of potential drug targets for the prevention and treatment of arterial dysfunction and the development of exercise regimens.https://www.mdpi.com/2218-273X/15/6/813exerciseproton-sensing G protein-coupled receptorsvascular endothelial cellvascular smooth muscle cellarterial function |
| spellingShingle | Fengzhi Yu Dandan Jia Ru Wang Proton-Sensing G Protein-Coupled Receptors and Their Potential Role in Exercise Regulation of Arterial Function Biomolecules exercise proton-sensing G protein-coupled receptors vascular endothelial cell vascular smooth muscle cell arterial function |
| title | Proton-Sensing G Protein-Coupled Receptors and Their Potential Role in Exercise Regulation of Arterial Function |
| title_full | Proton-Sensing G Protein-Coupled Receptors and Their Potential Role in Exercise Regulation of Arterial Function |
| title_fullStr | Proton-Sensing G Protein-Coupled Receptors and Their Potential Role in Exercise Regulation of Arterial Function |
| title_full_unstemmed | Proton-Sensing G Protein-Coupled Receptors and Their Potential Role in Exercise Regulation of Arterial Function |
| title_short | Proton-Sensing G Protein-Coupled Receptors and Their Potential Role in Exercise Regulation of Arterial Function |
| title_sort | proton sensing g protein coupled receptors and their potential role in exercise regulation of arterial function |
| topic | exercise proton-sensing G protein-coupled receptors vascular endothelial cell vascular smooth muscle cell arterial function |
| url | https://www.mdpi.com/2218-273X/15/6/813 |
| work_keys_str_mv | AT fengzhiyu protonsensinggproteincoupledreceptorsandtheirpotentialroleinexerciseregulationofarterialfunction AT dandanjia protonsensinggproteincoupledreceptorsandtheirpotentialroleinexerciseregulationofarterialfunction AT ruwang protonsensinggproteincoupledreceptorsandtheirpotentialroleinexerciseregulationofarterialfunction |