A Systematic Review on the Role of Desmoglein 1 and Desmoglein 3 in Etiopathogenesis and Metastasis of Oral Cancer
Background: Desmosomal proteins have a fundamental role in cellular adhesion as they not only maintain cellular homeostasis but also regulate cellular activities like proliferation, differentiation, and migration. Desmosomal protein expression, namely desmoglein 1 (DSG 1) and desmoglein 3 (DSG 3), i...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Journal of Indian Academy of Oral Medicine and Radiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jiaomr.jiaomr_283_24 |
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| Summary: | Background:
Desmosomal proteins have a fundamental role in cellular adhesion as they not only maintain cellular homeostasis but also regulate cellular activities like proliferation, differentiation, and migration. Desmosomal protein expression, namely desmoglein 1 (DSG 1) and desmoglein 3 (DSG 3), is known to play a crucial role in several types of cancers, including oral squamous cell carcinoma (OSCC).
Objectives:
The over- or underexpression of DSG 1 and DSG 3 can lead to alterations in oral epithelial cell-to-cell adhesion and plays a critical role in oral carcinogenesis and its metastasis.
Methods:
The initial online database search in Cochrane, PubMed, EMBASE, Scopus, and Medline between January 2003 and December 2023 along with a hand search of articles published up to March 2024, yielded 40 articles, and after further scrutiny, 15 articles fulfilled the final inclusion criteria.
Results:
The role of DSG 1 and DSG 3 in OSCC is not ascertained in the initiation of the disease; however, the expression of DSG 3 in metastatic lymph nodes has shown that it can be considered as a probable marker for distant metastasis.
Conclusion:
The exact role of DSG 1 and DSG 3 in OSCC needs further studies to exactly pinpoint their roles in oral cancer initiation, progression, and distant metastasis. |
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| ISSN: | 0972-1363 0975-1572 |