Adjunctive Sitagliptin Therapy in Postoperative Cardiac Surgery Patients: A Pilot Study
Aim. We aimed to determine if sitagliptin added to standard postoperative standardized sliding-scale insulin regimens improved blood glucose. Methods. A prospective, randomized, double-blind, placebo-controlled pilot study was conducted in diabetic cardiac surgery patients. Patients received sitagli...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/810926 |
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| author | Marcia L. Brackbill Ateequr Rahman Jeffrey S. Sandy M. Denton Stam Arthur F. Harralson |
| author_facet | Marcia L. Brackbill Ateequr Rahman Jeffrey S. Sandy M. Denton Stam Arthur F. Harralson |
| author_sort | Marcia L. Brackbill |
| collection | DOAJ |
| description | Aim. We aimed to determine if sitagliptin added to standard postoperative standardized sliding-scale insulin regimens improved blood glucose. Methods. A prospective, randomized, double-blind, placebo-controlled pilot study was conducted in diabetic cardiac surgery patients. Patients received sitagliptin or placebo after surgery for 4 days. The primary endpoint was to estimate the effect of adjunctive sitagliptin versus placebo on overall mean blood glucose in the 4-day period after surgery. Results. Sixty-two patients participated. Repeated measures tests indicated no significant difference between the groups in the overall mean blood glucose level with a mean of 147.2±4.8 mg/dL and 153.0±4.6 mg/dL for the test and the control group, respectively (P=0.388). Conclusions. Sitagliptin added to normal postoperative glucose management practices did not improve overall mean blood glucose control in diabetic patients in the postoperative setting. |
| format | Article |
| id | doaj-art-78369883d6bc42739feeb05b7ebd0561 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-78369883d6bc42739feeb05b7ebd05612025-02-03T01:30:50ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/810926810926Adjunctive Sitagliptin Therapy in Postoperative Cardiac Surgery Patients: A Pilot StudyMarcia L. Brackbill0Ateequr Rahman1Jeffrey S. Sandy2M. Denton Stam3Arthur F. Harralson4Winchester Medical Center, Heart and Vascular Center, Winchester, VA 22601, USAWinchester Medical Center, Heart and Vascular Center, Winchester, VA 22601, USAWinchester Medical Center, Heart and Vascular Center, Winchester, VA 22601, USAWinchester Medical Center, Heart and Vascular Center, Winchester, VA 22601, USAWinchester Medical Center, Heart and Vascular Center, Winchester, VA 22601, USAAim. We aimed to determine if sitagliptin added to standard postoperative standardized sliding-scale insulin regimens improved blood glucose. Methods. A prospective, randomized, double-blind, placebo-controlled pilot study was conducted in diabetic cardiac surgery patients. Patients received sitagliptin or placebo after surgery for 4 days. The primary endpoint was to estimate the effect of adjunctive sitagliptin versus placebo on overall mean blood glucose in the 4-day period after surgery. Results. Sixty-two patients participated. Repeated measures tests indicated no significant difference between the groups in the overall mean blood glucose level with a mean of 147.2±4.8 mg/dL and 153.0±4.6 mg/dL for the test and the control group, respectively (P=0.388). Conclusions. Sitagliptin added to normal postoperative glucose management practices did not improve overall mean blood glucose control in diabetic patients in the postoperative setting.http://dx.doi.org/10.1155/2012/810926 |
| spellingShingle | Marcia L. Brackbill Ateequr Rahman Jeffrey S. Sandy M. Denton Stam Arthur F. Harralson Adjunctive Sitagliptin Therapy in Postoperative Cardiac Surgery Patients: A Pilot Study International Journal of Endocrinology |
| title | Adjunctive Sitagliptin Therapy in Postoperative Cardiac Surgery Patients: A Pilot Study |
| title_full | Adjunctive Sitagliptin Therapy in Postoperative Cardiac Surgery Patients: A Pilot Study |
| title_fullStr | Adjunctive Sitagliptin Therapy in Postoperative Cardiac Surgery Patients: A Pilot Study |
| title_full_unstemmed | Adjunctive Sitagliptin Therapy in Postoperative Cardiac Surgery Patients: A Pilot Study |
| title_short | Adjunctive Sitagliptin Therapy in Postoperative Cardiac Surgery Patients: A Pilot Study |
| title_sort | adjunctive sitagliptin therapy in postoperative cardiac surgery patients a pilot study |
| url | http://dx.doi.org/10.1155/2012/810926 |
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